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Kcnj10
Gene Detail
Symbol

Name
ID
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
MGI:1194504
STS
Synonyms
BIR10, BIRK-1, Kir1.2, Kir4.1, Kir4.1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:172341210-172374085 bp, + strand
From VEGA annotation of GRCm38

  32876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNJ10
Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj10

Human
homologs
KCNJ10, potassium channel, inwardly rectifying subfamily J, member 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3766
neXtProt AC: NX_P78508

Human Synonyms: BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME

Human Chr (Location): 1q23.2; chr1:160037467-160070261 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human KCNJ10

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show increased input resistance and high depolarization of retinal Muller cells, loss of the endocochlear potential, motor coordination deficits and hindlimb paralysis, and a hypomyelination and spongiform vacuolation in the spinal cord associated with severe axonal pathology.
 
Interactions
Kcnj10 interacts with 403 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (13)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
RT-PCR 10
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnj10    NEW 
Molecular
reagents
All nucleic(42) Genomic(9) cDNA(31) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000050148 (Evidence)
Ensembl Gene Model ENSMUSG00000044708 (Evidence)
Entrez Gene 16513 (Evidence)
UniGene 254563
DFCI TC1598226, TC1583302
DoTS DT.94289231, DT.97411784, DT.97411785
NIA Mouse Gene Index U001106
Consensus CDS Project CCDS15512.1
International Mouse Phenotyping Consortium Status Kcnj10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050148 VEGA Gene Model | MGI Sequence Detail 32876 C57BL/6J ±  kb
transcript OTTMUST00000127496 VEGA | MGI Sequence Detail 5407 Not Applicable 
polypeptide OTTMUSP00000068763 VEGA | MGI Sequence Detail 379 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(5) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(379 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003269 Potassium channel, inwardly rectifying, Kir1.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001979 ATP-sensitive inward rectifier potassium channel 10
References
(Earliest) J:44256 Tada Y, et al., Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. Genomics. 1997 Nov 1;45(3):629-30
(Latest) J:217962 Sibille J, et al., Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse. J Physiol. 2014 Jan 1;592(Pt 1):87-102
All references(67)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory