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Kcnj10
Gene Detail
 Symbol
Name
ID
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
MGI:1194504
STS 416F4T7
Synonyms BIR10, BIRK-1, Kir1.2, Kir4.1, Kir4.1
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:172341210-172374085 bp, + strand
From NCBI annotation of GRCm38

  32876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj10

Human
homologs
Human Homolog KCNJ10, potassium inwardly-rectifying channel, subfamily J, member 10
NCBI Gene ID 3766
neXtProt AC  NX_P78508
Human Synonyms  BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
Human Chr (Location)  1q23.2; chr1:160037467-160070261 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human KCNJ10
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show increased input resistance and high depolarization of retinal Muller cells, loss of the endocochlear potential, motor coordination deficits and hindlimb paralysis, and a hypomyelination and spongiform vacuolation in the spinal cord associated with severe axonal pathology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process adult walking behavior, central nervous system myelination, ...
Component apical plasma membrane, astrocyte projection, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (12)    Images (12)
Theiler Stages: 13, 15, 17, 23, 25, 28
Assay TypeResults
RNA in situ 36
RT-PCR 10
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) Genomic(9) cDNA(31) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000044708 (Evidence)
Entrez Gene16513 (Evidence)
UniGene254563
DFCITC1583302, TC1598226
DoTSDT.94289231, DT.97411784, DT.97411785
NIA Mouse Gene IndexU001106
Consensus CDS ProjectCCDS15512.1
International Mouse Knockout Project StatusKcnj10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16513 NCBI Gene Model | MGI Sequence Detail 32876 C57BL/6J ±  kb
transcript NM_001039484 RefSeq | MGI Sequence Detail 5407 C57BL/6 
polypeptide Q9JM63 UniProt | EBI | MGI Sequence Detail 379 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(5) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(379 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003269 Potassium channel, inwardly rectifying, Kir1.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001979 ATP-sensitive inward rectifier potassium channel 10
Graphical View of Protein Domain Structure
References (Earliest) J:44256 Tada Y, et al., Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. Genomics. 1997 Nov 1;45(3):629-30
(Latest) J:203001 Zaika OL, et al., Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1277-87
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory