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Atp2a3
Gene Detail
Symbol

Name
ID
Atp2a3
ATPase, Ca++ transporting, ubiquitous
MGI:1194503
Synonyms
Serca3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:72961169-72993044 bp, + strand
From VEGA annotation of GRCm38

  31876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP2A3
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a3

Human
homologs
ATP2A3, ATPase, Ca++ transporting, ubiquitous
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 489
neXtProt AC: NX_Q93084

Human Synonyms: SERCA3

Human Chr (Location): 17p13.3; chr17:3923869-3964464 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Atp2a3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.
 
Interactions
Atp2a3 interacts with 203 markers (Mir1b, Mir22, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function ATP binding, calcium-transporting ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ATP2A3 ; Xenbase atp2a3 ; ZFIN atp2a3    NEW 
Molecular
reagents
All nucleic(112) Genomic(1) cDNA(111)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006323 (Evidence)
Ensembl Gene Model ENSMUSG00000020788 (Evidence)
Entrez Gene 53313 (Evidence)
UniGene 6306
DFCI TC1577006, TC1588255
DoTS DT.101371381, DT.97362372
NIA Mouse Gene Index U012888
EC 3.6.3.8
Consensus CDS Project CCDS24991.1, CCDS48842.1, CCDS48843.1
International Mouse Phenotyping Consortium Status Atp2a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006323 VEGA Gene Model | MGI Sequence Detail 31876 C57BL/6J ±  kb
transcript OTTMUST00000014354 VEGA | MGI Sequence Detail 4540 Not Applicable 
polypeptide OTTMUSP00000006654 VEGA | MGI Sequence Detail 1020 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR001757 P-type ATPase
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR005782 P-type ATPase, subfamily IIA, SERCA-type
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR030330 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Protein Ontology PR:000004444 sarcoplasmic/endoplasmic reticulum calcium ATPase 3
References
(Earliest) J:41924 Slack JP, et al., Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. J Biol Chem. 1997 Jul 25;272(30):18862-8
(Latest) J:217579 Anderson DM, et al., A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance. Cell. 2015 Jan 28;
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory