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Atp2a3 Gene Detail
Summary
  • Symbol
    Atp2a3
  • Name
    ATPase, Ca++ transporting, ubiquitous
  • Synonyms
    Serca3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194503
    NCBI Gene: 53313
  • Gene Overview
    MyGene.info: ATP2A3
Location & Maps
more
  • Sequence Map
    Chr11:72961169-72993044 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31876 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SERCA3
  • Links
    NCBI Gene ID: 489
    neXtProt AC: NX_Q93084

  • Chr Location
    17p13.3; chr17:3923869-3964464 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Atp2a3
  • Incidental Mutations
Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006323 VEGA Gene Model | MGI Sequence Detail 31876 C57BL/6J ±  kb
transcript OTTMUST00000014354 VEGA | MGI Sequence Detail 4540 Not Applicable  
polypeptide OTTMUSP00000006654 VEGA | MGI Sequence Detail 1020 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    208 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004444 sarcoplasmic/endoplasmic reticulum calcium ATPase 3
  • EC
  • InterPro Domains
    IPR006068 Cation-transporting P-type ATPase, C-terminal
    IPR004014 Cation-transporting P-type ATPase, N-terminal
    IPR023214 HAD-like domain
    IPR001757 P-type ATPase
    IPR008250 P-type ATPase, A domain
    IPR023299 P-type ATPase, cytoplasmic domain N
    IPR018303 P-type ATPase, phosphorylation site
    IPR005782 P-type ATPase, subfamily IIA, SERCA-type
    IPR023298 P-type ATPase, transmembrane domain
    IPR030330 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Molecular
Reagents
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  • All nucleic 112
    Genomic 1
    cDNA 111

    Microarray probesets 5
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:41924 Slack JP, et al., Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. J Biol Chem. 1997 Jul 25;272(30):18862-8
  • Latest
    J:217579 Anderson DM, et al., A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance. Cell. 2015 Jan 28;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory