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Atp2a3 Gene Detail
Summary
  • Symbol
    Atp2a3
  • Name
    ATPase, Ca++ transporting, ubiquitous
  • Synonyms
    Serca3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194503
    NCBI Gene: 53313
  • Gene Overview
    MyGene.info: ATP2A3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72961169-72993043 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194503
protein coding gene Chr11:72961169-72993044 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018647
protein coding gene Chr11:73626119-73660287 (+)
A/J MGP_AJ_G0018615
protein coding gene Chr11:70862661-70894505 (+)
AKR/J MGP_AKRJ_G0018584
protein coding gene Chr11:73019405-73052191 (+)
BALB/cJ MGP_BALBcJ_G0018587
protein coding gene Chr11:71164436-71196284 (+)
C3H/HeJ MGP_C3HHeJ_G0018400
protein coding gene Chr11:72983259-73016665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019038
protein coding gene Chr11:75843642-75880606 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016681
protein coding gene Chr11:67672425-67705433 (+)
CAST/EiJ MGP_CASTEiJ_G0017955
protein coding gene Chr11:73360653-73394017 (+)
CBA/J MGP_CBAJ_G0018372
protein coding gene Chr11:79216240-79251634 (+)
DBA/2J MGP_DBA2J_G0018481
protein coding gene Chr11:70493554-70525288 (+)
FVB/NJ MGP_FVBNJ_G0018472
protein coding gene Chr11:70037050-70069070 (+)
LP/J MGP_LPJ_G0018552
protein coding gene Chr11:74122782-74154463 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018495
protein coding gene Chr11:79743006-79775331 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019080
protein coding gene Chr11:73218615-73250252 (+)
PWK/PhJ MGP_PWKPhJ_G0017728
protein coding gene Chr11:71129236-71161427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017518
protein coding gene Chr11:72927362-72959954 (+)
WSB/EiJ MGP_WSBEiJ_G0018009
protein coding gene Chr11:72960722-72992787 (+)



Homology
more
  • Human Ortholog
    ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SERCA3
  • Links
    NCBI Gene ID: 489
    neXtProt AC: NX_Q93084
    UniProt: Q93084

  • Chr Location
    17p13.2; chr17:3923869-3964464 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 53313 NCBI Gene Model | MGI Sequence Detail 31875 C57BL/6J ±  kb
transcript NM_001163337 RefSeq | MGI Sequence Detail 4606 C57BL/6  
polypeptide Q64518 UniProt | EBI | MGI Sequence Detail 1038 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 113
    Genomic 1
    cDNA 112

    Microarray probesets 5
References
more
  • Summaries
    All 54
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:260257 Anderson DM, et al., Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Sci Signal. 2016 Dec 6;9(457):ra119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory