Atp2a3
Gene Detail

Symbol Name ID

Atp2a3 ATPase, Ca++ transporting, ubiquitous MGI:1194503

Synonyms

Serca3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:72961169-72993044 bp, + strand From VEGA annotation of GRCm38   31876 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2a3

Human homologs

Human Homolog		ATP2A3, ATPase, Ca++ transporting, ubiquitous
NCBI Gene ID		489
neXtProt AC		NX_Q93084
Human Synonyms		SERCA3
Human Chr (Location)		17p13.3; chr17:3827163-3867758 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	calcium ion transport, cation transport, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	ATP binding, calcium-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(111) Genomic(1) cDNA(110)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006323 (Evidence)
Ensembl Gene Model	ENSMUSG00000020788 (Evidence)
Entrez Gene	53313 (Evidence)
UniGene	6306
DFCI	TC1577006, TC1588255
DoTS	DT.101371381, DT.97362372
NIA Mouse Gene Index	U012888
EC	3.6.3.8
Consensus CDS Project	CCDS24991.1, CCDS48842.1, CCDS48843.1
International Mouse Knockout Project Status	Atp2a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006323	VEGA Gene Model | MGI Sequence Detail	31876	C57BL/6J
transcript	OTTMUST00000014354	VEGA | MGI Sequence Detail	4540	Not Applicable
polypeptide	OTTMUSP00000006654	VEGA | MGI Sequence Detail	1020	Not Applicable

All sequences(53) RefSeq(6) UniProt(9)

Polymorphisms

SNPs(126 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR005782	ATPase, P-type, calcium-transporting
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR000695	ATPase, P-type, H+ transporting proton pump
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004444	sarcoplasmic/endoplasmic reticulum calcium ATPase 3

References

(Earliest) J:41924 Slack JP, et al., Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. J Biol Chem. 1997 Jul 25;272(30):18862-8
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(44)