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Hdgf Gene Detail
Summary
  • Symbol
    Hdgf
  • Name
    hepatoma-derived growth factor
  • Synonyms
    D3Ertd299e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194494
    NCBI Gene: 15191
  • Gene Overview
    MyGene.info: HDGF
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87906321-87916132 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194494
protein coding gene Chr3:87906321-87916132 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027372
protein coding gene Chr3:88035298-88046174 (+)
A/J MGP_AJ_G0027336
protein coding gene Chr3:85048717-85058229 (+)
AKR/J MGP_AKRJ_G0027302
protein coding gene Chr3:87143451-87152962 (+)
BALB/cJ MGP_BALBcJ_G0027345
protein coding gene Chr3:85143991-85153500 (+)
C3H/HeJ MGP_C3HHeJ_G0027088
protein coding gene Chr3:87413124-87422639 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027791
protein coding gene Chr3:91278901-91288450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025144
protein coding gene Chr3:80671375-80680788 (+)
CAST/EiJ MGP_CASTEiJ_G0026535
protein coding gene Chr3:87619815-87629636 (+)
CBA/J MGP_CBAJ_G0027063
protein coding gene Chr3:94369095-94378605 (+)
DBA/2J MGP_DBA2J_G0027199
protein coding gene Chr3:84541271-84550796 (+)
FVB/NJ MGP_FVBNJ_G0027168
protein coding gene Chr3:82814223-82823741 (+)
LP/J MGP_LPJ_G0027307
protein coding gene Chr3:89000303-89009802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027187
protein coding gene Chr3:100617596-100627121 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027849
protein coding gene Chr3:86889973-86899799 (+)
PWK/PhJ MGP_PWKPhJ_G0026268
protein coding gene Chr3:84335427-84345383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026085
protein coding gene Chr3:86078207-86086816 (+)
WSB/EiJ MGP_WSBEiJ_G0026614
protein coding gene Chr3:87254757-87264273 (+)



Homology
more
  • Human Ortholog
    HDGF, heparin binding growth factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HDGF, heparin binding growth factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMG1L2
  • Links
    NCBI Gene ID: 3068
    neXtProt AC: NX_P51858
    UniProt: P51858

  • Chr Location
    1q23.1; chr1:156742107-156752448 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene are viable and fertile and display no major morphological, biochemical or behavioral phenotypes except for a significant reduction in rearing activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15191 NCBI Gene Model | MGI Sequence Detail 9812 C57BL/6J ±  kb
transcript NM_008231 RefSeq | MGI Sequence Detail 2257 C57BL/6  
polypeptide P51859 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 293
    cDNA 291
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGI:1098788, MGI:2139627
References
more
  • Summaries
    All 48
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:42918 Izumoto Y, et al., Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32
  • Latest
    J:260356 Aiello FB, et al., IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell Signal. 2018 Jul;47:131-141

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory