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Guca1b Gene Detail
Summary
  • Symbol
    Guca1b
  • Name
    guanylate cyclase activator 1B
  • Synonyms
    GCAP2, GCAP2 (retina)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194489
    NCBI Gene: 107477
  • Gene Overview
    MyGene.info: GUCA1B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47385393-47392967 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194489
protein coding gene Chr17:47384694-47392967 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023842
protein coding gene Chr17:48524922-48532459 (+)
A/J MGP_AJ_G0023800
protein coding gene Chr17:47325896-47333454 (+)
AKR/J MGP_AKRJ_G0023771
protein coding gene Chr17:47703627-47711174 (+)
BALB/cJ MGP_BALBcJ_G0023804
protein coding gene Chr17:47240556-47248103 (+)
C3H/HeJ MGP_C3HHeJ_G0023567
protein coding gene Chr17:48454178-48461740 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024247
protein coding gene Chr17:50593410-50600968 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021697
protein coding gene Chr17:44081540-44089009 (+)
CAST/EiJ MGP_CASTEiJ_G0023054
protein coding gene Chr17:48748365-48752269 (-)
CBA/J MGP_CBAJ_G0023544
protein coding gene Chr17:52445870-52456137 (+)
DBA/2J MGP_DBA2J_G0023670
protein coding gene Chr17:46084643-46092201 (+)
FVB/NJ MGP_FVBNJ_G0023637
protein coding gene Chr17:45726426-45734356 (+)
LP/J MGP_LPJ_G0023751
protein coding gene Chr17:49204431-49212219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023666
protein coding gene Chr17:51926791-51934341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024292
protein coding gene Chr17:48068744-48076285 (+)
PWK/PhJ MGP_PWKPhJ_G0022793
protein coding gene Chr17:45443922-45451604 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022609
protein coding gene Chr17:44964159-44972880 (+)
WSB/EiJ MGP_WSBEiJ_G0023114
protein coding gene Chr17:48648128-48655643 (+)



Homology
more
  • Human Ortholog
    GUCA1B, guanylate cyclase activator 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUCA1B, guanylate cyclase activator 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCAP2, GUCA2, RP48
  • Links
    NCBI Gene ID: 2979
    neXtProt AC: NX_Q9UMX6
    UniProt: Q9UMX6

  • Chr Location
    6p21.1; chr6:42183284-42194956 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1586
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GUCA1B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human GUCA1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal rod electrophysiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023979 Ensembl Gene Model | MGI Sequence Detail 7575 C57BL/6J ±  kb
transcript ENSMUST00000145462 Ensembl | MGI Sequence Detail 1556 Not Applicable  
polypeptide ENSMUSP00000126799 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    Genomic 4
    cDNA 81
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18680, MGI:101856, MGI:2385056
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:47304 Howes K, et al., Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Invest Ophthalmol Vis Sci. 1998 May;39(6):867-75
  • Latest
    J:263815 Lopez-Begines S, et al., Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina. Sci Rep. 2018 Feb 13;8(1):2903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory