About   Help   FAQ
Guca1b
Gene Detail
 Symbol
Name
ID
Guca1b
guanylate cyclase activator 1B
MGI:1194489
Synonyms GCAP2, GCAP2 (retina)
Feature Type protein coding gene
Genetic Map
Chromosome 17
23.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:47385393-47392967 bp, + strand
From VEGA annotation of GRCm38

  7575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1586  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Guca1b

Human
homologs
Human Homolog GUCA1B, guanylate cyclase activator 1B (retina)
NCBI Gene ID 2979
neXtProt AC  NX_Q9UMX6
Human Synonyms  GCAP2, GUCA2, RP48
Human Chr (Location)  6p21.1; chr6:42183284-42194956 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GUCA1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a null allele exhibit abnormal rod electrophysiology.
 
Interactions
Guca1b interacts with 67 markers (Mir34b, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process phototransduction, positive regulation of guanylate cyclase activity, ...
Component membrane, photoreceptor inner segment, ...
Function calcium ion binding, calcium sensitive guanylate cyclase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (4)    Images (2)
Theiler Stages: 24, 28
Assay TypeResults
RNA in situ 8
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(4) cDNA(80) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031580 (Evidence)
Ensembl Gene ModelENSMUSG00000023979 (Evidence)
Entrez Gene107477 (Evidence)
UniGene59151
DFCITC1578878, TC1591407
DoTSDT.91337002, DT.91403605
NIA Mouse Gene IndexU018058
Consensus CDS ProjectCCDS28847.1
International Mouse Knockout Project StatusGuca1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031580 VEGA Gene Model | MGI Sequence Detail 7575 C57BL/6J ±  kb
transcript OTTMUST00000078209 VEGA | MGI Sequence Detail 1556 Not Applicable 
polypeptide OTTMUSP00000051063 VEGA | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR015756 Guanylate cyclase activating protein 2
Protein Ontology PR:000008344 guanylyl cyclase-activating protein 2
References (Earliest) J:47304 Howes K, et al., Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Invest Ophthalmol Vis Sci. 1998 May;39(6):867-75
(Latest) J:202969 Reingruber J, et al., Detection of single photons by toad and mouse rods. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19378-83
All references(51)
Other
accession IDs
MGD-MRK-18680, MGI:101856, MGI:2385056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory