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Elf3
Gene Detail
 Symbol
Name
ID
Elf3
E74-like factor 3
MGI:1101781
Synonyms ESE-1, ESX, jen
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.42 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:135253575-135258568 bp, - strand
From VEGA annotation of GRCm38

  4994 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Elf3

Human
homologs
Human Homolog ELF3, E74-like factor 3 (ets domain transcription factor, epithelial-specific )
NCBI Gene ID 1999
neXtProt AC  NX_P78545
Human Synonyms  EPR-1, ERT, ESE-1, ESX
Human Chr (Location)  1q32.2; chr1:202010519-202017188 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
About one third of mice homozygous for a reporter allele die at E11.5; over half of those born develop a wasted phenotype, lethargy and watery diarrhea and die during the first few weeks of life exhibiting dysmorphogenesis and altered differentiation of small intestinal epithelium.
 
Interactions
Elf3 interacts with 107 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process anatomical structure morphogenesis, blastocyst development, ...
Component cytoplasm, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (351)    Tissues (237)    Images (65)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 296
Northern blot 31
RT-PCR 24
cDNA source data(180)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(185) Genomic(2) cDNA(180) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049800 (Evidence)
Ensembl Gene ModelENSMUSG00000003051 (Evidence)
Entrez Gene13710 (Evidence)
UniGene441439
DFCITC1575632
DoTSDT.101376431, DT.110917186, DT.491203, DT.94326466
NIA Mouse Gene IndexU021793
PDB3JTG
Consensus CDS ProjectCCDS48372.1
International Mouse Knockout Project StatusElf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049800 VEGA Gene Model | MGI Sequence Detail 4994 C57BL/6J ±  kb
transcript OTTMUST00000126843 VEGA | MGI Sequence Detail 2095 Not Applicable 
polypeptide OTTMUSP00000068569 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007022 ETS-related transcription factor Elf-3
References (Earliest) J:44178 Tymms MJ, et al., A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene. 1997 Nov 13;15(20):2449-62
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory