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Elf3 Gene Detail
Summary
  • Symbol
    Elf3
  • Name
    E74-like factor 3
  • Synonyms
    ESE-1, ESX, jen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101781
    NCBI Gene: 13710
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135253574-135258565 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.42 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101781
protein coding gene Chr1:135253574-135258568 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016519
protein coding gene Chr1:139007926-139012923 (-)
A/J MGP_AJ_G0016502
protein coding gene Chr1:133750009-133755006 (-)
AKR/J MGP_AKRJ_G0016467
protein coding gene Chr1:137730025-137735008 (-)
BALB/cJ MGP_BALBcJ_G0016462
protein coding gene Chr1:134061558-134066527 (-)
C3H/HeJ MGP_C3HHeJ_G0016288
protein coding gene Chr1:137829081-137834078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016923
protein coding gene Chr1:144033474-144038455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014634
protein coding gene Chr1:126856424-126861368 (-)
CAST/EiJ MGP_CASTEiJ_G0015868
protein coding gene Chr1:136904788-136909776 (-)
CBA/J MGP_CBAJ_G0016261
protein coding gene Chr1:149009016-149014010 (-)
DBA/2J MGP_DBA2J_G0016367
protein coding gene Chr1:132748748-132753781 (-)
FVB/NJ MGP_FVBNJ_G0016366
protein coding gene Chr1:131388407-131393895 (-)
LP/J MGP_LPJ_G0016438
protein coding gene Chr1:140245546-140250539 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016391
protein coding gene Chr1:154687631-154692625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016959
protein coding gene Chr1:137477430-137482412 (-)
PWK/PhJ MGP_PWKPhJ_G0015654
protein coding gene Chr1:131775149-131780146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015441
protein coding gene Chr1:136454791-136459767 (-)
WSB/EiJ MGP_WSBEiJ_G0015931
protein coding gene Chr1:137530061-137535058 (-)



Homology
more
  • Human Ortholog
    ELF3, E74 like ETS transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELF3, E74 like ETS transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPR-1, ERT, ESE-1, ESX
  • Links
    NCBI Gene ID: 1999
    neXtProt AC: NX_P78545
    UniProt: P78545

  • Chr Location
    1q32.1; chr1:202010519-202017188 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3265
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELF3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
About one third of mice homozygous for a reporter allele die at E11.5; over half of those born develop a wasted phenotype, lethargy and watery diarrhea and die during the first few weeks of life exhibiting dysmorphogenesis and altered differentiation of small intestinal epithelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13710 NCBI Gene Model | MGI Sequence Detail 4992 C57BL/6J ±  kb
    transcript NM_001163131 RefSeq | MGI Sequence Detail 2000 C57BL/6  
    polypeptide Q3UPW2 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 186
      Genomic 2
      cDNA 181
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261330 Wondimu EB, et al., Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis. Sci Rep. 2018 Apr 24;8(1):6438

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory