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Bmx
Gene Detail
Symbol

Name
ID
Bmx
BMX non-receptor tyrosine kinase
MGI:1101778
Synonyms
Etk, Etk/Bmx, Tyro8
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:164192842-164258193 bp, - strand
From VEGA annotation of GRCm38

  65352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Bmx

Human
homologs
Human Homolog BMX, BMX non-receptor tyrosine kinase
NCBI Gene ID 660
neXtProt AC  NX_P51813
Human Synonyms  ETK, PSCTK2, PSCTK3
Human Chr (Location)  Xp22.2; chrX:15500777-15556529 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
 
Mice homozygous for a null mutation are fertile and have a normal life span but are protected from arthritis in a passive transfer model.
 
Interactions
Bmx interacts with 171 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adaptive immune response, apoptotic process, ...
Component cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (86)    Tissues (65)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
Northern blot 5
RT-PCR 38
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019502 (Evidence)
Ensembl Gene ModelENSMUSG00000031377 (Evidence)
Entrez Gene12169 (Evidence)
UniGene504
DFCITC1587485
DoTSDT.101723582
NIA Mouse Gene IndexU039857
EC2.7.10.2
Consensus CDS ProjectCCDS30519.2
International Mouse Knockout Project StatusBmx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019502 VEGA Gene Model | MGI Sequence Detail 65352 C57BL/6J ±  kb
transcript OTTMUST00000046571 VEGA | MGI Sequence Detail 3005 Not Applicable 
polypeptide OTTMUSP00000021030 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000002200 cytoplasmic tyrosine-protein kinase BMX
References
(Earliest) J:36874 Rinke de Wit TF, et al., Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996 Nov;8(11):1787-95
(Latest) J:189306 Holopainen T, et al., Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012 Jul 15;72(14):3512-21
All references(44)
Other
accession IDs
MGD-MRK-38318, MGI:109273

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory