Bmx
Gene Detail

Symbol Name ID

Bmx BMX non-receptor tyrosine kinase MGI:1101778

Synonyms

Etk, Etk/Bmx, Tyro8

Feature Type

protein coding gene

Genetic Map

Chromosome X

76.12 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:164192842-164258193 bp, - strand From VEGA annotation of GRCm38   65352 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20411  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Bmx

Human homologs

Human Homolog		BMX, BMX non-receptor tyrosine kinase
NCBI Gene ID		660
neXtProt AC		NX_P51813
Human Synonyms		ETK, PSCTK2, PSCTK3
Human Chr (Location)		Xp22.2; chrX:15518900-15574652 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null mutation are fertile and have a normal life span but are protected from arthritis in a passive transfer model.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	apoptotic process, cell adhesion, ...
Component	cytoplasm, ruffle membrane
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (86)    Tissues (58)    Images (13)
Theiler Stages: 9, 15, 17, 19, 20, 23, 26, 28

Assay Type	Results
RNA in situ	43
Northern blot	5
RT-PCR	38

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019502 (Evidence)
Ensembl Gene Model	ENSMUSG00000031377 (Evidence)
Entrez Gene	12169 (Evidence)
UniGene	504
DFCI	TC1587485
DoTS	DT.101723582
NIA Mouse Gene Index	U039857
EC	2.7.10.2
Consensus CDS Project	CCDS30519.2
International Mouse Knockout Project Status	Bmx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019502	VEGA Gene Model | MGI Sequence Detail	65352	C57BL/6J
transcript	OTTMUST00000046571	VEGA | MGI Sequence Detail	3005	Not Applicable
polypeptide	OTTMUSP00000021030	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(27) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(203 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR001562	Zinc finger, Btk motif
Protein Ontology	PR:000002200	cytoplasmic tyrosine-protein kinase BMX

References

(Earliest) J:36874 Rinke de Wit TF, et al., Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996 Nov;8(11):1787-95
(Latest) J:189306 Holopainen T, et al., Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012 Jul 15;72(14):3512-21
All references(41)

Other accession IDs

MGD-MRK-38318, MGI:109273