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Pja1 Gene Detail
Summary
  • Symbol
    Pja1
  • Name
    praja ring finger ubiquitin ligase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101765
    NCBI Gene: 18744
  • Gene Overview
    MyGene.info: PJA1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:99465734-99471268 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101765
protein coding gene ChrX:99465734-99471273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035936
protein coding gene ChrX:95897907-95903421 (-)
A/J MGP_AJ_G0035921
protein coding gene ChrX:95948701-95954216 (-)
AKR/J MGP_AKRJ_G0035837
protein coding gene ChrX:98697528-98703057 (-)
BALB/cJ MGP_BALBcJ_G0035904
protein coding gene ChrX:94723215-94728722 (-)
C3H/HeJ MGP_C3HHeJ_G0035613
protein coding gene ChrX:96338837-96344337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036433
protein coding gene ChrX:98821897-98829009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033263
protein coding gene ChrX:93778192-93783636 (-)
CAST/EiJ MGP_CASTEiJ_G0034900
protein coding gene ChrX:80668250-80673742 (-)
CBA/J MGP_CBAJ_G0035588
protein coding gene ChrX:101855728-101861326 (-)
DBA/2J MGP_DBA2J_G0035742
protein coding gene ChrX:95189501-95195034 (-)
FVB/NJ MGP_FVBNJ_G0035680
protein coding gene ChrX:94584096-94589594 (-)
LP/J MGP_LPJ_G0035832
protein coding gene ChrX:96906029-96911573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035715
protein coding gene ChrX:106338213-106343718 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036460
protein coding gene ChrX:95636909-95642426 (-)
PWK/PhJ MGP_PWKPhJ_G0034599
protein coding gene ChrX:78305498-78311057 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034427
protein coding gene ChrX:81530389-81535528 (-)
WSB/EiJ MGP_WSBEiJ_G0035039
protein coding gene ChrX:94363424-94368944 (-)



Homology
more
  • Human Ortholog
    PJA1, praja ring finger ubiquitin ligase 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PJA1, praja ring finger ubiquitin ligase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRAJA1, RNF70
  • Links
    NCBI Gene ID: 64219
    neXtProt AC: NX_Q8NG27
    UniProt: Q8NG27

  • Chr Location
    Xq13.1; chrX:69160738-69165522 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Mice harboring an ENU-induced mutation show no detectable phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18744 NCBI Gene Model | MGI Sequence Detail 5535 C57BL/6J ±  kb
transcript NM_001290555 RefSeq | MGI Sequence Detail 3004 C57BL/6  
polypeptide O55176 UniProt | EBI | MGI Sequence Detail 578 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 132
    cDNA 132

    Microarray probesets 7
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:44194 Mishra L, et al., Praja1, a novel gene encoding a RING-H2 motif in mouse development. Oncogene. 1997 Nov 6;15(19):2361-8
  • Latest
    J:243917 Consalvi S, et al., Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation. Nat Commun. 2017 Jan 09;8:13956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory