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Rnf2
Gene Detail
Symbol

Name
ID
Rnf2
ring finger protein 2
MGI:1101759
Synonyms
dinG, Ring1B
Feature Type
protein coding gene
Genetic Map
Chromosome 1
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:151458004-151500955 bp, - strand
From VEGA annotation of GRCm38

  42952 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RNF2
Gene Tree: Rnf2

Human
homologs
RNF2, ring finger protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6045
neXtProt AC: NX_Q99496

Human Synonyms: BAP1, BAP-1, DING, HIPI3, RING1B, RING2

Human Chr (Location): 1q25.3; chr1:185045419-185102608 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(31) Targeted(8)
 
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
 
Interactions
Rnf2 interacts with 302 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (68)    Tissues (55)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
Western blot 2
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnf2 ; ZFIN rnf2    NEW 
Molecular
reagents
All nucleic(127) cDNA(127)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000049593 (Evidence)
Ensembl Gene Model ENSMUSG00000026484 (Evidence)
Entrez Gene 19821 (Evidence)
UniGene 474038
DFCI TC1572754, TC1707034
DoTS DT.101379298, DT.94163003, DT.94162995, DT.491002, DT.94162993
NIA Mouse Gene Index U021884
EC 6.3.2.-
PDB 2CKL
Consensus CDS Project CCDS15362.1
International Mouse Phenotyping Consortium Status Rnf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049593 VEGA Gene Model | MGI Sequence Detail 42952 C57BL/6J ±  kb
transcript OTTMUST00000126372 VEGA | MGI Sequence Detail 3201 Not Applicable 
polypeptide OTTMUSP00000068350 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000014115 E3 ubiquitin-protein ligase RING2
References
(Earliest) J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
(Latest) J:217589 Kawakami E, et al., The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Dev. 2015 Feb;135:31-42
All references(97)
Other
accession IDs
MGI:2138212, MGI:2138251, MGI:2138432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory