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Rnf2 Gene Detail
Summary
  • Symbol
    Rnf2
  • Name
    ring finger protein 2
  • Synonyms
    dinG, Ring1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101759
    NCBI Gene: 19821
  • Gene Overview
    MyGene.info: RNF2
Location & Maps
more
  • Sequence Map
    Chr1:151458004-151500955 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42952 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 64.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF2, ring finger protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF2, ring finger protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAP1, BAP-1, DING, HIPI3, RING1B, RING2
  • Links
    NCBI Gene ID: 6045
    neXtProt AC: NX_Q99496

  • Chr Location
    1q25.3; chr1:185045419-185102608 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2199
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RNF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Chemically induced (other)
    2
  • Gene trapped
    31
  • Targeted
    8
  • Genomic Mutations
    2 involving Rnf2
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049593 VEGA Gene Model | MGI Sequence Detail 42952 C57BL/6J ±  kb
transcript OTTMUST00000126372 VEGA | MGI Sequence Detail 3201 Not Applicable  
polypeptide OTTMUSP00000068350 VEGA | MGI Sequence Detail 336 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    406 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 128
    cDNA 127
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2138212, MGI:2138251, MGI:2138432
References
more
  • Summaries
    All 97
    Developmental Gene Expression 31
    Gene Ontology 25
    Phenotypes 31
  • Earliest
    J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
  • Latest
    J:230833 Mardaryev AN, et al., Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4;212(1):77-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory