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Rnf2 Gene Detail
Summary
  • Symbol
    Rnf2
  • Name
    ring finger protein 2
  • Synonyms
    dinG, Ring1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101759
    NCBI Gene: 19821
  • Gene Overview
    MyGene.info: RNF2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:151469406-151500922 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 64.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101759
protein coding gene Chr1:151458004-151500955 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016582
protein coding gene Chr1:156189786-156234768 (-)
A/J MGP_AJ_G0016564
protein coding gene Chr1:149881235-149929566 (-)
AKR/J MGP_AKRJ_G0016529
protein coding gene Chr1:154494310-154538915 (-)
BALB/cJ MGP_BALBcJ_G0016524
protein coding gene Chr1:150455870-150498230 (-)
C3H/HeJ MGP_C3HHeJ_G0016349
protein coding gene Chr1:154634958-154680621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016985
protein coding gene Chr1:161591801-161638429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014694
protein coding gene Chr1:142218910-142257192 (-)
CAST/EiJ MGP_CASTEiJ_G0015928
protein coding gene Chr1:154066232-154112835 (-)
CBA/J MGP_CBAJ_G0016323
protein coding gene Chr1:167277887-167320991 (-)
DBA/2J MGP_DBA2J_G0016429
protein coding gene Chr1:148929006-148971707 (-)
FVB/NJ MGP_FVBNJ_G0016427
protein coding gene Chr1:147381253-147426677 (-)
LP/J MGP_LPJ_G0016500
protein coding gene Chr1:157240840-157285983 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016453
protein coding gene Chr1:174984626-175028122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017021
protein coding gene Chr1:154265497-154308569 (-)
PWK/PhJ MGP_PWKPhJ_G0015714
protein coding gene Chr1:147890599-147934514 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015501
protein coding gene Chr1:153097473-153141801 (-)
WSB/EiJ MGP_WSBEiJ_G0015991
protein coding gene Chr1:154361269-154399729 (-)



Homology
more
  • Human Ortholog
    RNF2, ring finger protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF2, ring finger protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAP1, BAP-1, DING, HIPI3, RING1B, RING2
  • Links
    NCBI Gene ID: 6045
    neXtProt AC: NX_Q99496
    UniProt: Q99496

  • Chr Location
    1q25.3; chr1:185045419-185102608 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2199
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RNF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19821 NCBI Gene Model | MGI Sequence Detail 31517 C57BL/6J ±  kb
    transcript NM_001360844 RefSeq | MGI Sequence Detail 3576 C57BL/6  
    polypeptide Q9CQJ4 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      cDNA 128
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138212, MGI:2138251, MGI:2138432
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 32
      Gene Ontology 28
      Phenotypes 35
    • Earliest
      J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
    • Latest
      J:251488 Li H, et al., RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. Cell Stem Cell. 2017 Apr 6;20(4):462-477.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory