About   Help   FAQ
Rnf2
Gene Detail
 Symbol
Name
ID
Rnf2
ring finger protein 2
MGI:1101759
Synonyms dinG, Ring1B
Feature Type protein coding gene
Genetic Map
Chromosome 1
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:151458004-151500955 bp, - strand
From VEGA annotation of GRCm38

  42952 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rnf2

Human
homologs
Human Homolog RNF2, ring finger protein 2
NCBI Gene ID 6045
neXtProt AC  NX_Q99496
Human Synonyms  BAP1, BAP-1, DING, HIPI3, RING1B, RING2
Human Chr (Location)  1q25.3; chr1:185045419-185102608 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(34) Targeted(8)
 
Embryos homozygous for a null allele show an early growth arrest, failure to progress through gastrulation, impaired epiblast expansion, accumulation of posterior mesoderm and die before E10.5. Mice homozygous for a hypomorphic allele show posterior homeotic transformations of the axial skeleton.
 
Interactions
Rnf2 interacts with 302 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process anterior/posterior axis specification, gastrulation with mouth forming second, ...
Component chromosome, euchromatin, ...
Function chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (68)    Tissues (55)    Images (23)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 26, 27
Assay TypeResults
RNA in situ 66
Western blot 2
cDNA source data(125)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) cDNA(127)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000049593 (Evidence)
Ensembl Gene ModelENSMUSG00000026484 (Evidence)
Entrez Gene19821 (Evidence)
UniGene474038
DFCITC1572754, TC1707034
DoTSDT.101379298, DT.491002, DT.94162993, DT.94162995, DT.94163003
NIA Mouse Gene IndexU021884
EC6.3.2.-
PDB2CKL
Consensus CDS ProjectCCDS15362.1
International Mouse Knockout Project StatusRnf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049593 VEGA Gene Model | MGI Sequence Detail 42952 C57BL/6J ±  kb
transcript OTTMUST00000126372 VEGA | MGI Sequence Detail 3201 Not Applicable 
polypeptide OTTMUSP00000068350 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000014115 E3 ubiquitin-protein ligase RING2
References (Earliest) J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
(Latest) J:208353 Kondo T, et al., Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell. 2014 Jan 13;28(1):94-101
All references(93)
Other
accession IDs
MGI:2138212, MGI:2138251, MGI:2138432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory