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Npepps Gene Detail
Summary
  • Symbol
    Npepps
  • Name
    aminopeptidase puromycin sensitive
  • Synonyms
    MP100, Psa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101358
    NCBI Gene: 19155
  • Gene Overview
    MyGene.info: NPEPPS
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:97205842-97280638 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74797 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.95 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NPEPPS, aminopeptidase puromycin sensitive
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPEPPS, aminopeptidase puromycin sensitive
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAP-S, MP100, PSA
  • Links
    NCBI Gene ID: 9520
    neXtProt AC: NX_P55786
    UniProt: P55786

  • Chr Location
    17q21.32; chr17:47522950-47623276 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36199
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NPEPPS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trapped mutation exhibit dwarfism, increased anxiety, decreased pain sensitivity, and infertility in both sexes. Females fail to produce the corpus luteum of pregnancy, while males fail to copulate and have impaired spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002302 VEGA Gene Model | MGI Sequence Detail 74797 C57BL/6J ±  kb
    transcript OTTMUST00000004584 VEGA | MGI Sequence Detail 4215 Not Applicable  
    polypeptide OTTMUSP00000002198 VEGA | MGI Sequence Detail 920 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      367 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
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    MGI:2144698, MGI:2673208
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:43396 Constam DB, et al., Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. J Biol Chem. 1995 Nov 10;270(45):26931-9
    • Latest
      J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory