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Ece2 Gene Detail
Summary
  • Symbol
    Ece2
  • Name
    endothelin converting enzyme 2
  • Synonyms
    1810009K13Rik, 6330509A19Rik, 9630025D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101356
    NCBI Gene: 107522
Location & Maps
more
  • Sequence Map
    Chr16:20611593-20646485 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34893 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.48 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 9718
    neXtProt AC: NX_O60344

  • Chr Location
    3q27.1; chr3:184249657-184293031 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028772 VEGA Gene Model | MGI Sequence Detail 34893 C57BL/6J ±  kb
transcript OTTMUST00000071264 VEGA | MGI Sequence Detail 3432 Not Applicable  
polypeptide OTTMUSP00000036480 VEGA | MGI Sequence Detail 910 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1913525, MGI:2146683, MGI:2444026
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
  • Latest
    J:178451 Miller LK, et al., Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. J Neurochem. 2011 Dec;119(5):1074-1085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory