Ece2
Gene Detail

Symbol Name ID

Ece2 endothelin converting enzyme 2 MGI:1101356

Synonyms

1810009K13Rik, 6330509A19Rik, 9630025D12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.48 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:20611593-20646485 bp, + strand From VEGA annotation of GRCm38   34893 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Ece2

Human homologs

Human Homolog		ECE2, endothelin converting enzyme 2
NCBI Gene ID		9718
neXtProt AC		NX_O60344
Human Chr (Location)		3q28-q29; chr3:183967445-184010819 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(5)
 

Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	metabolic process, methylation, ...
Component	cytoplasmic vesicle membrane, Golgi apparatus, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (45)    Tissues (33)    Images (12)
Theiler Stages: 17, 20, 21, 23, 28

Assay Type	Results
RNA in situ	18
Northern blot	18
RT-PCR	9

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028772 (Evidence)
Ensembl Gene Model	ENSMUSG00000022842 (Evidence)
Entrez Gene	107522 (Evidence)
UniGene	263319
DFCI	TC1583381, TC1584343, TC1597958, TC1620551
DoTS	DT.101232295, DT.101379715, DT.491040, DT.60104393, DT.91380847, DT.91564614
NIA Mouse Gene Index	U016928
EC	2.1.1.-, 3.4.24.71
Consensus CDS Project	CCDS28052.1, CCDS37290.1, CCDS49793.1, CCDS49794.1, CCDS49796.1
International Mouse Knockout Project Status	Ece2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028772	VEGA Gene Model | MGI Sequence Detail	34893	C57BL/6J
transcript	OTTMUST00000071264	VEGA | MGI Sequence Detail	3432	Not Applicable
polypeptide	OTTMUSP00000036480	VEGA | MGI Sequence Detail	910	Not Applicable

All sequences(98) RefSeq(10) UniProt(14)

Polymorphisms

SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR013216	Methyltransferase type 11
InterPro	IPR000718	Peptidase M13
InterPro	IPR018497	Peptidase M13, C-terminal domain
InterPro	IPR008753	Peptidase M13, N-terminal domain
Protein Ontology	PR:000006875	endothelin-converting enzyme 2

References

(Earliest) J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
(Latest) J:178451 Miller LK, et al., Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. J Neurochem. 2011 Dec;119(5):1074-1085
All references(41)

Other accession IDs

MGI:1913525, MGI:2146683, MGI:2444026