About   Help   FAQ
Ece2 Gene Detail
Summary
  • Symbol
    Ece2
  • Name
    endothelin converting enzyme 2
  • Synonyms
    1810009K13Rik, 6330509A19Rik, 9630025D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101356
    NCBI Gene: 107522
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20629828-20646485 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.48 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101356
protein coding gene Chr16:20611601-20646485 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022648
protein coding gene Chr16:17949016-17985490 (+)
A/J MGP_AJ_G0022610
protein coding gene Chr16:17086071-17120868 (+)
AKR/J MGP_AKRJ_G0022585
protein coding gene Chr16:17732730-17767521 (+)
BALB/cJ MGP_BALBcJ_G0022614
protein coding gene Chr16:17243741-17278800 (+)
C3H/HeJ MGP_C3HHeJ_G0022379
protein coding gene Chr16:17898970-17933883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023065
protein coding gene Chr16:18296325-18333136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020582
protein coding gene Chr16:17771679-17809196 (+)
CAST/EiJ MGP_CASTEiJ_G0021909
protein coding gene Chr16:17873073-17907944 (+)
CBA/J MGP_CBAJ_G0022351
protein coding gene Chr16:19049325-19087896 (+)
DBA/2J MGP_DBA2J_G0022483
protein coding gene Chr16:17012364-17047649 (+)
FVB/NJ MGP_FVBNJ_G0022458
protein coding gene Chr16:17047865-17084456 (+)
LP/J MGP_LPJ_G0022550
protein coding gene Chr16:17680838-17716798 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022478
protein coding gene Chr16:18729545-18768099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023076
protein coding gene Chr16:17698006-17737569 (+)
PWK/PhJ MGP_PWKPhJ_G0021650
protein coding gene Chr16:17275394-17311505 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021479
protein coding gene Chr16:17496358-17541080 (+)
WSB/EiJ MGP_WSBEiJ_G0021953
protein coding gene Chr16:17691946-17732409 (+)



Homology
more
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EEF1AKMT4
  • Links
    NCBI Gene ID: 9718
    neXtProt AC: NX_P0DPD6, NX_P0DPD8
    UniProt: P0DPD6

  • Chr Location
    3q27.1; chr3:184249657-184293031 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    2 images
    6 phenotype references
Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022842 Ensembl Gene Model | MGI Sequence Detail 16658 C57BL/6J ±  kb
transcript ENSMUST00000003898 Ensembl | MGI Sequence Detail 3152 Not Applicable  
polypeptide ENSMUSP00000003898 Ensembl | MGI Sequence Detail 763 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 34
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913525, MGI:2146683, MGI:2444026
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
  • Latest
    J:239563 Pacheco-Quinto J, et al., Major amyloid-beta-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex. Neurobiol Aging. 2016 Dec;48:83-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory