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Ece2
Gene Detail
 Symbol
Name
ID
Ece2
endothelin converting enzyme 2
MGI:1101356
Synonyms 1810009K13Rik, 6330509A19Rik, 9630025D12Rik
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.48 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:20611593-20646485 bp, + strand
From VEGA annotation of GRCm38

  34893 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Ece2

Human
homologs
Human Homolog ECE2, endothelin converting enzyme 2
NCBI Gene ID 9718
neXtProt AC  NX_O60344
Human Chr (Location)  3q27.1; chr3:184249657-184293031 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Ece2 interacts with 278 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process metabolic process, methylation, ...
Component cytoplasmic vesicle membrane, Golgi apparatus, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (45)    Tissues (33)    Images (12)
Theiler Stages: 17, 20, 21, 23, 28
Assay TypeResults
RNA in situ 18
Northern blot 18
RT-PCR 9
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028772 (Evidence)
Ensembl Gene ModelENSMUSG00000022842 (Evidence)
Entrez Gene107522 (Evidence)
UniGene263319
DFCITC1583381, TC1584343, TC1597958, TC1620551
DoTSDT.101232295, DT.101379715, DT.491040, DT.60104393, DT.91380847, DT.91564614
NIA Mouse Gene IndexU016928
EC2.1.1.-, 3.4.24.71
Consensus CDS ProjectCCDS28052.1, CCDS37290.1, CCDS49793.1, CCDS49794.1, CCDS49796.1
International Mouse Knockout Project StatusEce2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028772 VEGA Gene Model | MGI Sequence Detail 34893 C57BL/6J ±  kb
transcript OTTMUST00000071264 VEGA | MGI Sequence Detail 3432 Not Applicable 
polypeptide OTTMUSP00000036480 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(32) UniProt(14)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR013216 Methyltransferase type 11
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000006875 endothelin-converting enzyme 2
References (Earliest) J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
(Latest) J:178451 Miller LK, et al., Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. J Neurochem. 2011 Dec;119(5):1074-1085
All references(42)
Other
accession IDs
MGI:1913525, MGI:2146683, MGI:2444026

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory