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Ece2 Gene Detail
Summary
  • Symbol
    Ece2
  • Name
    endothelin converting enzyme 2
  • Synonyms
    1810009K13Rik, 6330509A19Rik, 9630025D12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101356
    NCBI Gene: 107522
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20448601-20464665 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.48 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101356
 protein coding gene Chr16:20448578-20465235 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022648
 protein coding gene Chr16:17949016-17985490 (+)
A/J MGP_AJ_G0022610
 protein coding gene Chr16:17086071-17120868 (+)
AKR/J MGP_AKRJ_G0022585
 protein coding gene Chr16:17732730-17767521 (+)
BALB/cJ MGP_BALBcJ_G0022614
 protein coding gene Chr16:17243741-17278800 (+)
C3H/HeJ MGP_C3HHeJ_G0022379
 protein coding gene Chr16:17898970-17933883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023065
 protein coding gene Chr16:18296325-18333136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020582
 protein coding gene Chr16:17771679-17809196 (+)
CAST/EiJ MGP_CASTEiJ_G0021909
 protein coding gene Chr16:17873073-17907944 (+)
CBA/J MGP_CBAJ_G0022351
 protein coding gene Chr16:19049325-19087896 (+)
DBA/2J MGP_DBA2J_G0022483
 protein coding gene Chr16:17012364-17047649 (+)
FVB/NJ MGP_FVBNJ_G0022458
 protein coding gene Chr16:17047865-17084456 (+)
LP/J MGP_LPJ_G0022550
 protein coding gene Chr16:17680838-17716798 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022478
 protein coding gene Chr16:18729545-18768099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023076
 protein coding gene Chr16:17698006-17737569 (+)
PWK/PhJ MGP_PWKPhJ_G0021650
 protein coding gene Chr16:17275394-17311505 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021479
 protein coding gene Chr16:17496358-17541080 (+)
WSB/EiJ MGP_WSBEiJ_G0021953
 protein coding gene Chr16:17691946-17732409 (+)



Homology
more
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECE2, endothelin converting enzyme 2
  • Synonyms
    EEF1AKMT4
  • Links
    NCBI Gene ID: 9718
    neXtProt AC: NX_P0DPD6, NX_P0DPD8
    UniProt: P0DPD6

  • Chr Location
    3q27.1; chr3:184276011-184293031 (+)  GRCh38
  • Human Ortholog
    EEF1AKMT4-ECE2, EEF1AKMT4-ECE2 readthrough
  • Synonyms
    ECE2, ECE-2
  • Links
    NCBI Gene ID: 110599583
    neXtProt AC: NX_P0DPD6, NX_P0DPD8
    UniProt: P0DPD8

  • Chr Location
    3q27.1; chr3:184249672-184293031 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    2 images
    7 phenotype references
Homozygous mutant mice develop normally, are viable and healthy, and exhibit normal fertility in both sexes, as well as a normal life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    37
  • cDNA Data
    34
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 107522 NCBI Gene Model | MGI Sequence Detail 16065 C57BL/6J ±  kb
transcript NM_139293 RefSeq | MGI Sequence Detail 3129 C57BL/6  
polypeptide NP_647454 RefSeq | MGI Sequence Detail 763 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 34
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913525, MGI:2146683, MGI:2444026
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:42648 Emoto N, et al., Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem. 1995 Jun 23;270(25):15262-8
  • Latest
    J:239563 Pacheco-Quinto J, et al., Major amyloid-beta-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex. Neurobiol Aging. 2016 Dec;48:83-92
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory