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Klf10
Gene Detail
Symbol

Name
ID
Klf10
Kruppel-like factor 10
MGI:1101353
Synonyms
Egral, Gdnfif, mGIF, Tieg1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:38294413-38300707 bp, - strand
From Ensembl annotation of GRCm38

  6295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Klf10

Human
homologs
Human Homolog KLF10, Kruppel-like factor 10
NCBI Gene ID 7071
neXtProt AC  NX_Q13118
Human Synonyms  EGRA, EGR-alpha, TIEG, TIEG1
Human Chr (Location)  8q22.2; chr8:102648777-102655902 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display increased osteoblast formation and impaired osteoblast function.
 
Interactions
Klf10 interacts with 243 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process bone mineralization, cellular response to starvation, ...
Component nucleus
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (118)    Tissues (84)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
RT-PCR 44
cDNA source data(73)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) Genomic(1) cDNA(76) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000037465 (Evidence)
Entrez Gene21847 (Evidence)
UniGene4292
DFCITC1595252, TC1594949, TC1574624
DoTSDT.531219, DT.99868086
NIA Mouse Gene IndexU036114
Consensus CDS ProjectCCDS27438.1
International Mouse Knockout Project StatusKlf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037465 Ensembl Gene Model | MGI Sequence Detail 6295 C57BL/6J ±  kb
transcript ENSMUST00000074043 Ensembl | MGI Sequence Detail 3045 Not Applicable 
polypeptide ENSMUSP00000073690 Ensembl | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009354 krueppel-like factor 10
References
(Earliest) J:29718 Blok LJ, et al., Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol Endocrinol. 1995 Nov;9(11):1610-20
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(65)
Other
accession IDs
MGD-MRK-36079, MGI:107509, MGI:2145945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory