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Klf10
Gene Detail
 Symbol
Name
ID
Klf10
Kruppel-like factor 10
MGI:1101353
Synonyms Egral, Gdnfif, mGIF, Tieg1
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:38294413-38300707 bp, - strand
From NCBI annotation of GRCm38

  6295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Klf10

Human
homologs
Human Homolog KLF10, Kruppel-like factor 10
NCBI Gene ID 7071
neXtProt AC  NX_Q13118
Human Synonyms  EGRA, EGR-alpha, TIEG, TIEG1
Human Chr (Location)  8q22.2; chr8:102648777-102655902 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display increased osteoblast formation and impaired osteoblast function.
 
Interactions
Klf10 interacts with 243 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process bone mineralization, cellular response to starvation, ...
Component nucleus
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (118)    Tissues (84)    Images (13)
Theiler Stages: 2, 3, 4, 5, 14, 17, 18, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 74
RT-PCR 44
cDNA source data(73)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) Genomic(1) cDNA(76) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000037465 (Evidence)
Entrez Gene21847 (Evidence)
UniGene4292
DFCITC1574624, TC1594949, TC1595252
DoTSDT.531219, DT.99868086
NIA Mouse Gene IndexU036114
Consensus CDS ProjectCCDS27438.1
International Mouse Knockout Project StatusKlf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21847 NCBI Gene Model | MGI Sequence Detail 6295 C57BL/6J ±  kb
transcript NM_013692 RefSeq | MGI Sequence Detail 3056 C57BL/6 
polypeptide O89091 UniProt | EBI | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009354 krueppel-like factor 10
Graphical View of Protein Domain Structure
References (Earliest) J:29718 Blok LJ, et al., Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol Endocrinol. 1995 Nov;9(11):1610-20
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(65)
Other
accession IDs
MGD-MRK-36079, MGI:107509, MGI:2145945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory