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Klf10 Gene Detail
Summary
  • Symbol
    Klf10
  • Name
    Kruppel-like factor 10
  • Synonyms
    Egral, Gdnfif, mGIF, Tieg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101353
    NCBI Gene: 21847
  • Gene Overview
    MyGene.info: KLF10
Location & Maps
more
  • Sequence Map
    Chr15:38294413-38300707 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6295 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLF10, Kruppel like factor 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KLF10, Kruppel like factor 10
    Orthology source: HomoloGene
  • Synonyms
    EGRA, EGR-alpha, TIEG, TIEG1
  • Links
    NCBI Gene ID: 7071
    neXtProt AC: NX_Q13118

  • Chr Location
    8q22.2; chr8:102648777-102655902 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Targeted
    5
  • Genomic Mutations
    2 involving Klf10
  • Incidental Mutations
Homozygous mutants display increased osteoblast formation and impaired osteoblast function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037465 Ensembl Gene Model | MGI Sequence Detail 6295 C57BL/6J ±  kb
transcript ENSMUST00000074043 Ensembl | MGI Sequence Detail 3045 Not Applicable  
polypeptide ENSMUSP00000073690 Ensembl | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009354 krueppel-like factor 10
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 80
    Genomic 1
    cDNA 76
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36079, MGI:107509, MGI:2145945
References
more
  • Summaries
    All 62
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 28
  • Earliest
    J:29718 Blok LJ, et al., Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol Endocrinol. 1995 Nov;9(11):1610-20
  • Latest
    J:223856 Papadakis KA, et al., Kruppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-beta signaling in CD8+ T lymphocytes. Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C362-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory