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Ifit3 Gene Detail
Summary
  • Symbol
    Ifit3
  • Name
    interferon-induced protein with tetratricopeptide repeats 3
  • Synonyms
    Ifi49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101055
    NCBI Gene: 15959
  • Gene Overview
    MyGene.info: IFIT3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34583531-34588731 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.74 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101055
protein coding gene Chr19:34583142-34588982 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025062
protein coding gene Chr19:33367111-33368778 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0025005
protein coding gene Chr19:32840163-32841833 (+)
BALB/cJ MGP_BALBcJ_G0025035
protein coding gene Chr19:31848258-31849928 (+)
C3H/HeJ MGP_C3HHeJ_G0024793
protein coding gene Chr19:32914847-32919832 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025476
protein coding gene Chr19:34317754-34321276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022895
protein coding gene Chr19:31165457-31170657 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024771
protein coding gene Chr19:35948653-35950320 (+)
DBA/2J MGP_DBA2J_G0024902
protein coding gene Chr19:31621033-31622700 (+)
FVB/NJ MGP_FVBNJ_G0024865
protein coding gene Chr19:31476062-31481233 (+)
LP/J MGP_LPJ_G0024989
protein coding gene Chr19:33447527-33449194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024894
protein coding gene Chr19:35708893-35728647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025534
protein coding gene Chr19:32910021-32916295 (+)
PWK/PhJ MGP_PWKPhJ_G0024012
protein coding gene Chr19:31423596-31425366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023814
protein coding gene Chr19:31750219-31755416 (+)
WSB/EiJ MGP_WSBEiJ_G0024328
protein coding gene Chr19:32997501-32999171 (+)



Homology
more
  • Human Ortholog
    IFIT3, interferon induced protein with tetratricopeptide repeats 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IFIT3, interferon induced protein with tetratricopeptide repeats 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cig41, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G
  • Links
    NCBI Gene ID: 3437
    neXtProt AC: NX_O14879
    UniProt: O14879

  • Chr Location
    10q23.31; chr10:89327819-89340968 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074896 Ensembl Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
transcript ENSMUST00000102825 Ensembl | MGI Sequence Detail 1745 Not Applicable  
polypeptide ENSMUSP00000099889 Ensembl | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR024122 Interferon-induced protein with tetratricopeptide repeats 3
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 33
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 1
  • Earliest
    J:18633 Lee CG, et al., Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol. 1994 Jun 15;152(12):5758-67
  • Latest
    J:259382 Torre S, et al., USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017 Jan;18(1):54-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory