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Sepw1
Gene Detail
Symbol

Name
ID
Sepw1
selenoprotein W, muscle 1
MGI:1100878
Feature Type
protein coding gene
Genetic Map
Chromosome 7
8.62 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:15917208-15922402 bp, - strand
From VEGA annotation of GRCm38

  5195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SEPW1
Gene Tree: Sepw1

Human
homologs
SEPW1, selenoprotein W, 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6415
neXtProt AC: NX_P63302

Human Synonyms: selW

Human Chr (Location): 19q13.3; chr19:47778585-47784682 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sepw1 interacts with 43 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell redox homeostasis, oxidation-reduction process
Component cytoplasm, plasma membrane
Function antioxidant activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (26)    Tissues (5)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
cDNA source data(285)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN sepw1    NEW 
Molecular
reagents
All nucleic(288) Genomic(3) cDNA(285)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021063 (Evidence)
Ensembl Gene Model ENSMUSG00000041571 (Evidence)
Entrez Gene 20364 (Evidence)
UniGene 42829
DFCI TC1572150, TC1765032
DoTS DT.537155, DT.101309272, DT.94306742
NIA Mouse Gene Index U028172
PDB 2NPB
Consensus CDS Project CCDS39778.1
International Mouse Phenotyping Consortium Status Sepw1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021063 VEGA Gene Model | MGI Sequence Detail 5195 C57BL/6J ±  kb
transcript OTTMUST00000049826 VEGA | MGI Sequence Detail 736 Not Applicable 
polypeptide OTTMUSP00000023148 VEGA | MGI Sequence Detail 88 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011893 Selenoprotein, Rdx type
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000014662 selenoprotein W
References
(Earliest) J:41818 Gu QP, et al., Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. Gene. 1997 Jul 9;193(2):187-96
(Latest) J:212456 Jeon YH, et al., Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein. Biochim Biophys Acta. 2014 Jul;1843(7):1356-64
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory