About   Help   FAQ
Plagl1 Gene Detail
Summary
  • Symbol
    Plagl1
  • Name
    pleiomorphic adenoma gene-like 1
  • Synonyms
    Zac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100874
    NCBI Gene: 22634
  • Gene Overview
    MyGene.info: PLAGL1
Location & Maps
more
  • Sequence Map
    Chr10:13060504-13131694 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71191 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 4.72 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
    Orthology source: HomoloGene
  • Synonyms
    LOT1, ZAC, ZAC1
  • Links
    NCBI Gene ID: 5325
    neXtProt AC: NX_Q9UM63

  • Chr Location
    6q24-q25; chr6:143940300-144064599 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PLAGL1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Transient Neonatal, 1   OMIM: 601410 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    9
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031215 VEGA Gene Model | MGI Sequence Detail 71191 C57BL/6J ±  kb
transcript OTTMUST00000077318 VEGA | MGI Sequence Detail 5260 Not Applicable  
polypeptide OTTMUSP00000040866 VEGA | MGI Sequence Detail 704 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    671 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR027775 C2H2- zinc finger protein family
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
    IPR027770 Zinc finger protein PLAGL1
Molecular
Reagents
less
  • All nucleic 72
    cDNA 66
    Primer pair 5
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 74
    Developmental Gene Expression 38
    Diseases 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
  • Latest
    J:226471 Adnani L, et al., Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015 Sep 30;35(39):13430-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory