Plagl1
Gene Detail

Symbol Name ID

Plagl1 pleiomorphic adenoma gene-like 1 MGI:1100874

Synonyms

Zac1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

4.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:13090691-13131694 bp, + strand From VEGA annotation of GRCm38   41004 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31401  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Plagl1

Human homologs

Human Homolog		PLAGL1, pleiomorphic adenoma gene-like 1
NCBI Gene ID		5325
neXtProt AC		NX_Q9UM63
Human Synonyms		LOT1, ZAC, ZAC1
Human Chr (Location)		6q24-q25; chr6:144261437-144385735 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLAGL1

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(9)
 

Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (444)    Tissues (255)    Images (54)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	341
In situ reporter (knock in)	50
Northern blot	6
RT-PCR	47

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031215 (Evidence)
Ensembl Gene Model	ENSMUSG00000019817 (Evidence)
Entrez Gene	22634 (Evidence)
DFCI	TC1580483, TC1593489, TC1660422, TC1682448, TC1720191
DoTS	DT.103572822, DT.110589919, DT.91336601, DT.99857584, DT.99857585, DT.99857587
NIA Mouse Gene Index	U043048
Consensus CDS Project	CCDS48501.1
International Mouse Knockout Project Status	Plagl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031215	VEGA Gene Model | MGI Sequence Detail	41004	C57BL/6J
transcript	OTTMUST00000077318	VEGA | MGI Sequence Detail	5260	Not Applicable
polypeptide	OTTMUSP00000040866	VEGA | MGI Sequence Detail	704	Not Applicable

All sequences(106) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(299 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000012823	zinc finger protein PLAGL1

References

(Earliest) J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
(Latest) J:187821 Iglesias-Platas I, et al., Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin. PLoS One. 2012;7(6):e38907
All references(72)