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Plagl1 Gene Detail
Summary
  • Symbol
    Plagl1
  • Name
    pleiomorphic adenoma gene-like 1
  • Synonyms
    Zac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100874
    NCBI Gene: 22634
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:12966576-13007438 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 4.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100874
protein coding gene Chr10:12936248-13007438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017018
protein coding gene Chr10:10454066-10526599 (+)
A/J MGP_AJ_G0016996
protein coding gene Chr10:10054842-10132023 (+)
AKR/J MGP_AKRJ_G0016960
protein coding gene Chr10:10287069-10359007 (+)
BALB/cJ MGP_BALBcJ_G0016954
protein coding gene Chr10:10054741-10130227 (+)
C3H/HeJ MGP_C3HHeJ_G0016779
protein coding gene Chr10:10448240-10519800 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017416
protein coding gene Chr10:10734243-10807756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015121
protein coding gene Chr10:9340047-9410303 (+)
CAST/EiJ MGP_CASTEiJ_G0016361
protein coding gene Chr10:10304479-10379136 (+)
CBA/J MGP_CBAJ_G0016751
protein coding gene Chr10:11132202-11211825 (+)
DBA/2J MGP_DBA2J_G0016859
protein coding gene Chr10:9965773-10037024 (+)
FVB/NJ MGP_FVBNJ_G0016854
protein coding gene Chr10:9805681-9877266 (+)
LP/J MGP_LPJ_G0016934
protein coding gene Chr10:10312431-10385245 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016884
protein coding gene Chr10:11044350-11119495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017454
protein coding gene Chr10:10173026-10249398 (+)
PWK/PhJ MGP_PWKPhJ_G0016146
protein coding gene Chr10:9847187-9919409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015929
protein coding gene Chr10:10308290-10415717 (+)
WSB/EiJ MGP_WSBEiJ_G0016423
protein coding gene Chr10:10219706-10292900 (+)



Homology
more
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
  • Synonyms
    LOT1, ZAC, ZAC1
  • Links
    NCBI Gene ID: 5325
    neXtProt AC: NX_Q9UM63
    UniProt: Q9UM63

  • Chr Location
    6q24.2; chr6:143940300-144064599 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22634 NCBI Gene Model | MGI Sequence Detail 40863 C57BL/6J ±  kb
    transcript NM_009538 RefSeq | MGI Sequence Detail 5235 ZRU/MplStud  
    polypeptide NP_033564 RefSeq | MGI Sequence Detail 704 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 69
      Primer pair 11
      Other 5

      Microarray probesets 5
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 52
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
    • Latest
      J:319920 Ypsilanti AR, et al., Transcriptional network orchestrating regional patterning of cortical progenitors. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2024795118

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory