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Plagl1
Gene Detail
Symbol

Name
ID
Plagl1
pleiomorphic adenoma gene-like 1
MGI:1100874
Synonyms
Zac1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
4.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:13060504-13131694 bp, + strand
From VEGA annotation of GRCm38

  71191 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PLAGL1
Gene Tree: Plagl1

Human
homologs
PLAGL1, pleiomorphic adenoma gene-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5325
neXtProt AC: NX_Q9UM63

Human Synonyms: LOT1, ZAC, ZAC1

Human Chr (Location): 6q24-q25; chr6:143940300-144064599 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLAGL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Plagl1 interacts with 229 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (36 records)
Data Summary: Results (600)    Tissues (347)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 488
In situ reporter (knock in) 50
Northern blot 6
RT-PCR 47
cDNA source data(65)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(65) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031215 (Evidence)
Ensembl Gene Model ENSMUSG00000019817 (Evidence)
Entrez Gene 22634 (Evidence)
UniGene 287857
DFCI TC1580483, TC1720191, TC1682448, TC1660422, TC1593489
DoTS DT.99857587, DT.99857585, DT.99857584, DT.91336601, DT.103572822, DT.110589919
NIA Mouse Gene Index U043048
Consensus CDS Project CCDS48501.1
International Mouse Phenotyping Consortium Status Plagl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031215 VEGA Gene Model | MGI Sequence Detail 71191 C57BL/6J ±  kb
transcript OTTMUST00000077318 VEGA | MGI Sequence Detail 5260 Not Applicable 
polypeptide OTTMUSP00000040866 VEGA | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(2) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(679 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000012823 zinc finger protein PLAGL1
References
(Earliest) J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
(Latest) J:206605 Faisal M, et al., Sexual differences of imprinted genes' expression levels. Gene. 2014 Jan 1;533(1):434-8
All references(76)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory