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Plagl1
Gene Detail
 Symbol
Name
ID
Plagl1
pleiomorphic adenoma gene-like 1
MGI:1100874
Synonyms Zac1
Feature Type protein coding gene
Genetic Map
Chromosome 10
4.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:13090691-13131694 bp, + strand
From VEGA annotation of GRCm38

  41004 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Plagl1

Human
homologs
Human Homolog PLAGL1, pleiomorphic adenoma gene-like 1
NCBI Gene ID 5325
neXtProt AC  NX_Q9UM63
Human Synonyms  LOT1, ZAC, ZAC1
Human Chr (Location)  6q24-q25; chr6:143940300-144064599 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLAGL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.
 
Interactions
Plagl1 interacts with 229 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, regulation of gene expression, ...
Component cytoplasm, Golgi apparatus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (600)    Tissues (336)    Images (111)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 488
In situ reporter (knock in) 50
Northern blot 6
RT-PCR 47
cDNA source data(65)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(65) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031215 (Evidence)
Ensembl Gene ModelENSMUSG00000019817 (Evidence)
Entrez Gene22634 (Evidence)
UniGene287857
DFCITC1580483, TC1593489, TC1660422, TC1682448, TC1720191
DoTSDT.103572822, DT.110589919, DT.91336601, DT.99857584, DT.99857585, DT.99857587
NIA Mouse Gene IndexU043048
Consensus CDS ProjectCCDS48501.1
International Mouse Knockout Project StatusPlagl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031215 VEGA Gene Model | MGI Sequence Detail 41004 C57BL/6J ±  kb
transcript OTTMUST00000077318 VEGA | MGI Sequence Detail 5260 Not Applicable 
polypeptide OTTMUSP00000040866 VEGA | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(2) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(419 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000012823 zinc finger protein PLAGL1
References (Earliest) J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
(Latest) J:198902 Vincent A, et al., Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium. Cardiovasc Res. 2012 May 1;94(2):351-8
All references(77)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory