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Gcnt2
Gene Detail
Symbol

Name
ID
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
MGI:1100870
Synonyms
5330430K10Rik, IGnT, IGnTA, IGnTB, IGnTC
Feature Type
protein coding gene
Genetic Map
Chromosome 13
20.12 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:40859768-40960891 bp, + strand
From Ensembl annotation of GRCm38

  101124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog

Gene Tree: Gcnt2

Human
homologs
Human Homolog GCNT2, glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
NCBI Gene ID 2651
neXtProt AC  NX_Q06430, NX_Q8N0V5, NX_Q8NFS9
Human Synonyms  bA360O19.2, bA421M1.1, CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3
Human Chr (Location)  6p24.2; chr6:10521283-10629368 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(122) : Gene trapped(120) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show hypoactivity, a reduced B cell number, epidermoid cyst formation in male abdominal skin, and impaired renal function with increased blood urea nitrogen and creatinine levels and vacuolization of renal tubular epithelial cells in aging mice.
 
Interactions
Gcnt2 interacts with 286 markers (Mir7-1, Mir15a, Mir15b, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (156)    Tissues (113)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 128
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(9)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021360 Ensembl Gene Model | MGI Sequence Detail 101124 C57BL/6J ±  kb
transcript ENSMUST00000110191 Ensembl | MGI Sequence Detail 4342 Not Applicable 
polypeptide ENSMUSP00000105820 Ensembl | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(8) UniProt(19)
Polymorphisms
SNPs within 2kb(410 from dbSNP Build 137)    SNPs within 2kb including multiple locations(412)
Protein-related
information
ResourceIDDescription
InterPro IPR003406 Glycosyl transferase, family 14
Protein Ontology PR:000007904 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
References
(Earliest) J:32534 Lee JE, et al., Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development. 1990 Sep;110(1):151-9
(Latest) J:205650 Zhang H, et al., Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling. Cancer Res. 2011 Jul 15;71(14):4846-56
All references(41)
Other
accession IDs
MGI:1925531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory