Gcnt2
Gene Detail

Symbol Name ID

Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme MGI:1100870

Synonyms

5330430K10Rik, IGnT, IGnTA, IGnTB, IGnTC

Feature Type

protein coding gene

Genetic Map

Chromosome 13

20.12 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:40859768-40960891 bp, + strand From Ensembl annotation of GRCm38   101124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Gcnt2

Human homologs

Human Homolog		GCNT2, glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
NCBI Gene ID		2651
neXtProt AC		NX_Q06430, NX_Q8N0V5, NX_Q8NFS9
Human Synonyms		bA360O19.2, bA421M1.1, CCAT, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3
Human Chr (Location)		6p24.2; chr6:10521568-10629601 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(122) : Targeted(2) Gene trapped(120)
 

Mice homozygous for a knock-out allele show hypoactivity, a reduced B cell number, epidermoid cyst formation in male abdominal skin, and impaired renal function with increased blood urea nitrogen and creatinine levels and vacuolization of renal tubular epithelial cells in aging mice.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	metabolic process
Component	Golgi apparatus, integral to membrane, ...
Function	acetylglucosaminyltransferase activity, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (156)    Tissues (113)    Images (24)
Theiler Stages: 12, 22, 23

Assay Type	Results
Immunohistochemistry	28
RNA in situ	128

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000021360 (Evidence)
Entrez Gene	14538 (Evidence)
DFCI	TC1584765, TC1584886, TC1585003, TC1608697, TC1663086, TC1718394
DoTS	DT.101376139, DT.101387781, DT.101406963, DT.110971395, DT.91338751, DT.94299631, DT.94310206, DT.97334692, DT.97361430, DT.99855725
EC	2.4.1.150
Consensus CDS Project	CCDS26468.1, CCDS26469.1, CCDS36637.1
International Mouse Knockout Project Status	Gcnt2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021360	Ensembl Gene Model | MGI Sequence Detail	101124	C57BL/6J
transcript	ENSMUST00000110191	Ensembl | MGI Sequence Detail	4342	Not Applicable
polypeptide	ENSMUSP00000105820	Ensembl | MGI Sequence Detail	401	Not Applicable

All sequences(72) RefSeq(6) UniProt(11)

Polymorphisms

SNPs(366 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003406	Glycosyl transferase, family 14
Protein Ontology	PR:000007904	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

References

(Earliest) J:32534 Lee JE, et al., Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development. 1990 Sep;110(1):151-9
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)

Other accession IDs

MGI:1925531