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Ap3b2
Gene Detail
Symbol

Name
ID
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
MGI:1100869
Synonyms
beta3B, MGC:36656, Naptb
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:81460399-81493925 bp, - strand
From VEGA annotation of GRCm38

  33527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP3B2
Protein SuperFamily: adaptor protein complex AP-3, beta subunit
Gene Tree: Ap3b2

Human
homologs
AP3B2, adaptor-related protein complex 3, beta 2 subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8120
neXtProt AC: NX_Q13367

Human Synonyms: NAPTB

Human Chr (Location): 15q; chr15:82659281-82709908 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Disruption does not alter pigmentation, but causes hyperactivity and tonic-clonic seizures and mice homozygous for a knock-out allele were found to have significantly reduced synaptic zinc levels throughout the brain, with the largest reduction observed in the CA1 stratum oriens.
 
Interactions
Ap3b2 interacts with 57 markers (Mir1a-1, Mir1a-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component AP-3 adaptor complex, cell, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (132)    Tissues (31)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 122
Western blot 4
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap3b2    NEW 
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031672 (Evidence)
Ensembl Gene Model ENSMUSG00000062444 (Evidence)
Entrez Gene 11775 (Evidence)
UniGene 322894
DFCI TC1644737, TC1621474, TC1579440
DoTS DT.101334616, DT.484272, DT.101248174, DT.94170442, DT.94131669, DT.99763830
NIA Mouse Gene Index U028779
Consensus CDS Project CCDS21403.1
International Mouse Phenotyping Consortium Status Ap3b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031672 VEGA Gene Model | MGI Sequence Detail 33527 C57BL/6J ±  kb
transcript OTTMUST00000078465 VEGA | MGI Sequence Detail 3804 Not Applicable 
polypeptide OTTMUSP00000041716 VEGA | MGI Sequence Detail 1082 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(5) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026740 AP-3 complex subunit beta
InterPro IPR026739 AP complex subunit beta
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004105 AP-3 complex subunit beta-2
References
(Earliest) J:52144 Newman LS, et al., Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell. 1995 Sep 8;82(5):773-83
(Latest) J:187545 Larimore J, et al., The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011 Dec;22(24):4854-67
All references(37)
Other
accession IDs
MGI:2141995, MGI:2142157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory