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Ap3b2
Gene Detail
 Symbol
Name
ID
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
MGI:1100869
Synonyms beta3B, MGC:36656, Naptb
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:81460399-81493925 bp, - strand
From VEGA annotation of GRCm38

  33527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adaptor protein complex AP-3, beta subunit
Gene Tree: Ap3b2

Human
homologs
Human Homolog AP3B2, adaptor-related protein complex 3, beta 2 subunit
NCBI Gene ID 8120
neXtProt AC  NX_Q13367
Human Synonyms  NAPTB
Human Chr (Location)  15q; chr15:82659281-82709908 (-)  GRCh38
Alleles
and
phenotypes
All alleles(12) : Gene trapped(9) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption does not alter pigmentation, but causes hyperactivity and tonic-clonic seizures and mice homozygous for a knock-out allele were found to have significantly reduced synaptic zinc levels throughout the brain, with the largest reduction observed in the CA1 stratum oriens.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component AP-3 adaptor complex, cell, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (110)    Tissues (16)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 110
cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031672 (Evidence)
Ensembl Gene ModelENSMUSG00000062444 (Evidence)
Entrez Gene11775 (Evidence)
UniGene322894
DFCITC1579440, TC1621474, TC1644737
DoTSDT.101248174, DT.101334616, DT.484272, DT.94131669, DT.94170442, DT.99763830
NIA Mouse Gene IndexU028779
Consensus CDS ProjectCCDS21403.1
International Mouse Knockout Project StatusAp3b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031672 VEGA Gene Model | MGI Sequence Detail 33527 C57BL/6J ±  kb
transcript OTTMUST00000078465 VEGA | MGI Sequence Detail 3804 Not Applicable 
polypeptide OTTMUSP00000041716 VEGA | MGI Sequence Detail 1082 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(5) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026740 AP-3 complex subunit beta
InterPro IPR026739 AP complex subunit beta
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004105 AP-3 complex subunit beta-2
References (Earliest) J:52144 Newman LS, et al., Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell. 1995 Sep 8;82(5):773-83
(Latest) J:187545 Larimore J, et al., The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011 Dec;22(24):4854-67
All references(39)
Other
accession IDs
MGI:2141995, MGI:2142157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory