About   Help   FAQ
Kpna3 Gene Detail
Summary
  • Symbol
    Kpna3
  • Name
    karyopherin (importin) alpha 3
  • Synonyms
    importin alpha 4, IPOA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100863
    NCBI Gene: 16648
  • Gene Overview
    MyGene.info: KPNA3
Location & Maps
more
  • Sequence Map
    Chr14:61365186-61439947 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 32.76 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KPNA3, karyopherin subunit alpha 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KPNA3, karyopherin subunit alpha 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hSRP1, IPOA4, SRP1, SRP1gamma, SRP4
  • Links
    NCBI Gene ID: 3839
    neXtProt AC: NX_O00505

  • Chr Location
    13q14.3; chr13:49699307-49792921 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    3
  • Genomic Mutations
    1 involving Kpna3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a null mutation are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16648 NCBI Gene Model | MGI Sequence Detail 74762 C57BL/6J ±  kb
transcript NM_008466 RefSeq | MGI Sequence Detail 4167 C57BL/6  
polypeptide O35344 UniProt | EBI | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    188 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 199
    cDNA 198
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
  • Latest
    J:228044 Mihalas BP, et al., Changing expression and subcellular distribution of karyopherins during murine oogenesis. Reproduction. 2015 Dec;150(6):485-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory