About   Help   FAQ
Frs2 Gene Detail
Summary
  • Symbol
    Frs2
  • Name
    fibroblast growth factor receptor substrate 2
  • Synonyms
    C330018A15Rik, Frs2alpha, SNT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100860
    NCBI Gene: 327826
  • Gene Overview
    MyGene.info: FRS2
Location & Maps
more
  • Sequence Map
    Chr10:117070129-117148474 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78346 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FRS2, fibroblast growth factor receptor substrate 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRS2, fibroblast growth factor receptor substrate 2
    Orthology source: HomoloGene
  • Synonyms
    FRS1A, FRS2A, FRS2alpha, SNT, SNT1, SNT-1
  • Links
    NCBI Gene ID: 10818
    neXtProt AC: NX_Q8WU20

  • Chr Location
    12q15; chr12:69470349-69579793 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4846
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FRS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 7 genetic backgrounds
    3 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    69
  • Chemically induced (other)
    1
  • Gene trapped
    60
  • Targeted
    8
  • Genomic Mutations
    1 involving Frs2
  • Incidental Mutations
Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020170 Ensembl Gene Model | MGI Sequence Detail 78346 C57BL/6J ±  kb
transcript ENSMUST00000020381 Ensembl | MGI Sequence Detail 5682 Not Applicable  
polypeptide ENSMUSP00000020381 Ensembl | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    361 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007670 fibroblast growth factor receptor substrate 2
  • InterPro Domains
    IPR002404 IRS-type PTB domain
    IPR011993 PH domain-like
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2442871
References
more
  • Summaries
    All 66
    Developmental Gene Expression 18
    Gene Ontology 16
    Phenotypes 38
  • Earliest
    J:40779 Kouhara H, et al., A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 1997 May 30;89(5):693-702
  • Latest
    J:229400 Chen PY, et al., Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest. 2015 Dec;125(12):4514-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory