Frs2 MGI Mouse Gene Detail - MGI:1100860 - fibroblast growth factor receptor substrate 2

Symbol

Frs2
Name

fibroblast growth factor receptor substrate 2
Synonyms

C330018A15Rik, Frs2alpha, SNT1

Feature Type

protein coding gene
IDs

MGI:1100860
NCBI Gene: 327826
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:116905332-116984439 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 65.09 cM
Mapping Data

2 experiments

SNPs within 2kb

1583 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100860	protein coding gene	Chr10:116905324-116986311 (-)
129S1/SvImJ	ENSMUSG00200025071	protein coding gene	Chr10:113315578-113394676 (-)
A/J	ENSMUSG00195020036	protein coding gene	Chr10:113750333-113829454 (-)
AKR/J	ENSMUSG00220014606	protein coding gene	Chr10:113323954-113403079 (-)
BALB/cJ	ENSMUSG00180016170	protein coding gene	Chr10:113767276-113846376 (-)
C3H/HeJ	ENSMUSG00175023913	protein coding gene	Chr10:113712511-113791580 (-)
C57BL/6NJ	ENSMUSG00215012492	protein coding gene	Chr10:113408564-113487667 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015828	protein coding gene	Chr10:109860154-109937196 (-)
CAST/EiJ	ENSTCUG00005031753	protein coding gene	Chr10:112733113-112812265 (-)
CBA/J	ENSMUSG00210020644	protein coding gene	Chr10:113562091-113641148 (-)
DBA/2J	ENSMUSG00185007959	protein coding gene	Chr10:113686638-113765734 (-)
FVB/NJ	ENSMUSG00205016405	protein coding gene	Chr10:113011229-113090329 (-)
JF1/MsJ	ENSUMUG00000014037	protein coding gene	Chr10:115004504-115072556 (-)
LP/J	ENSMUSG00230022647	protein coding gene	Chr10:115636397-115715453 (-)
NOD/ShiLtJ	ENSMUSG00190017865	protein coding gene	Chr10:113811791-113890868 (-)
NZO/HlLtJ	ENSMUSG00225017221	protein coding gene	Chr10:119890452-119969558 (-)
PWK/PhJ	ENSLUMG00010012381	protein coding gene	Chr10:113389914-113469840 (-)
SPRET/EiJ	ENSMSPG00010014811	protein coding gene	Chr10:115335827-115362363 (-)
WSB/EiJ	ENSIUOG00005012886	protein coding gene	Chr10:113405617-113484554 (-)

Human Ortholog

FRS2, fibroblast growth factor receptor substrate 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FRS2, fibroblast growth factor receptor substrate 2
Synonyms

FRS1A, FRS2A, FRS2alpha, SNT, SNT-1, SNT1
Links

HGNC:16971

NCBI Gene ID: 10818

UniProt: Q8WU20
Chr Location

12q15; chr12:69470349-69579793 (+) GRCh38

MGI Vertebrate Homology

Frs2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FRS2
Gene Tree

Frs2

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Phenotype Summary

28 phenotypes from 6 alleles in 7 genetic backgrounds
9 phenotypes from multigenic genotypes
3 images
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Chemically induced (other)

1
Gene trapped

51
Targeted

8
Genomic Mutations

1 involving Frs2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation.

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All GO Annotations

49
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

106
cDNA Data

14
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase frs2

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All Sequences

88
RefSeq

48
UniProt

2
CCDS

CCDS24190.1

Ensembl

ENSMUSG00000020170 (Evidence)
NCBI Gene

327826

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020170	Ensembl Gene Model \| MGI Sequence Detail	79108	C57BL/6J	± kb
transcript	ENSMUST00000020381	Ensembl \| MGI Sequence Detail	6420	Not Applicable
polypeptide	ENSMUSP00000020381	Ensembl \| MGI Sequence Detail	508	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007670 fibroblast growth factor receptor substrate 2

(term hierarchy)
InterPro Domains

IPR050996 Docking Protein Family (DOK)

IPR038742 FRS2, PTB domain

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily
GlyGen

Q8C180 4 sites, 1 O-linked glycan (3 sites)

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All nucleic 19

cDNA 15

Primer pair 3

Other 1

Antibodies 7

Microarray probesets 4

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MGI:2442871

Summaries

All 117

Developmental Gene Expression 28

Gene Ontology 19

Phenotypes 55
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:375721 Wang Q, et al., Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development. Elife. 2025 May 6;13

TSS for Frs2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99392	Chr10:116986305-116986318 (-)	-1,873 bp
Tssr99391	Chr10:116984416-116984451 (-)	5 bp
Tssr99390	Chr10:116984386-116984415 (-)	38 bp
Tssr99389	Chr10:116952393-116952397 (-)	32,044 bp
Tssr99388	Chr10:116923032-116923035 (-)	61,405 bp
Tssr99387	Chr10:116907992-116907993 (-)	76,446 bp
Tssr99386	Chr10:116907875-116907889 (-)	76,557 bp
Tssr99385	Chr10:116907694-116907711 (-)	76,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24