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Frs2 Gene Detail
Summary
  • Symbol
    Frs2
  • Name
    fibroblast growth factor receptor substrate 2
  • Synonyms
    C330018A15Rik, Frs2alpha, SNT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100860
    NCBI Gene: 327826
  • Gene Overview
    MyGene.info: FRS2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117070127-117148474 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100860
protein coding gene Chr10:117069427-117148534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017753
protein coding gene Chr10:119895348-120005040 (-)
A/J MGP_AJ_G0017729
protein coding gene Chr10:115266786-115348522 (-)
AKR/J MGP_AKRJ_G0017691
protein coding gene Chr10:118616917-118708158 (-)
BALB/cJ MGP_BALBcJ_G0017692
protein coding gene Chr10:115667395-115749680 (-)
C3H/HeJ MGP_C3HHeJ_G0017517
protein coding gene Chr10:118841075-118940144 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018149
protein coding gene Chr10:124056644-124147077 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015828
protein coding gene Chr10:109860154-109937196 (-)
CAST/EiJ MGP_CASTEiJ_G0017079
protein coding gene Chr10:119153183-119249680 (-)
CBA/J MGP_CBAJ_G0017486
protein coding gene Chr10:128941935-129038155 (-)
DBA/2J MGP_DBA2J_G0017591
protein coding gene Chr10:114405851-114486332 (-)
FVB/NJ MGP_FVBNJ_G0017586
protein coding gene Chr10:113356334-113437570 (-)
LP/J MGP_LPJ_G0017666
protein coding gene Chr10:120481977-120570784 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017615
protein coding gene Chr10:131810506-131902383 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018187
protein coding gene Chr10:118684751-118771954 (-)
PWK/PhJ MGP_PWKPhJ_G0016861
protein coding gene Chr10:114505825-114586200 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016651
protein coding gene Chr10:117495271-117574319 (-)
WSB/EiJ MGP_WSBEiJ_G0017139
protein coding gene Chr10:118887708-118969493 (-)



Homology
more
  • Human Ortholog
    FRS2, fibroblast growth factor receptor substrate 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRS2, fibroblast growth factor receptor substrate 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRS1A, FRS2A, FRS2alpha, SNT, SNT1, SNT-1
  • Links
    NCBI Gene ID: 10818
    neXtProt AC: NX_Q8WU20
    UniProt: Q8WU20

  • Chr Location
    12q15; chr12:69470349-69579793 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4846
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FRS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    3 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 327826 NCBI Gene Model | MGI Sequence Detail 78348 C57BL/6J ±  kb
    transcript NM_177798 RefSeq | MGI Sequence Detail 5701 C57BL/6  
    polypeptide Q8C180 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442871
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 23
      Gene Ontology 16
      Phenotypes 44
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory