Capn5
Gene Detail

Symbol Name ID

Capn5 calpain 5 MGI:1100859

Feature Type

protein coding gene

Genetic Map

Chromosome 7

53.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:98121559-98178274 bp, - strand From VEGA annotation of GRCm38   56716 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Capn5 ± 2 cM)

Gene Tree: Capn5

Human ortholog

CAPN5 calpain 5 NCBI Gene ID 726
Human Synonyms: HTRA3, nCL-3
Human Chr11:76777992-76837201 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(31) : Targeted(4) Gene trapped(27)
 

Mice homozygous for one allele of this gene occasionally exhibit reduced viability but are usually normal. Homozygotes for another allele die as embryos.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	proteolysis
Component	intracellular
Function	calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (162)    Tissues (87)    Images (82)
Theiler Stages: 20, 22, 24, 25, 28

Assay Type	Results
RNA in situ	11
In situ reporter (knock in)	112
RT-PCR	39

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(1) cDNA(67) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022532 (Evidence)
Ensembl Gene Model	ENSMUSG00000035547 (Evidence)
Entrez Gene	12337 (Evidence)
UniGene	326847
DFCI	TC1576538
DoTS	DT.532227, DT.91368465
NIA Mouse Gene Index	U028880
EC	3.4.22.-
Consensus CDS Project	CCDS21465.1
International Mouse Knockout Project Status	Capn5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022532	VEGA Gene Model | MGI Sequence Detail	56716	C57BL/6J
transcript	OTTMUST00000053964	VEGA | MGI Sequence Detail	4498	Not Applicable
polypeptide	OTTMUSP00000025702	VEGA | MGI Sequence Detail	640	Not Applicable

All sequences(43) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(439 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR001300	Peptidase C2, calpain, catalytic domain
InterPro	IPR022683	Peptidase C2, calpain, domain III
InterPro	IPR022684	Peptidase C2, calpain family
InterPro	IPR022682	Peptidase C2, calpain, large subunit, domain III
Protein Ontology	PR:000005017	calpain-5

References

(Earliest) J:43496 Dear N, et al., A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(38)