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Mras
Gene Detail
 Symbol
Name
ID
Mras
muscle and microspikes RAS
MGI:1100856
Synonyms 2900078C09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
51.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:99385422-99436881 bp, - strand
From VEGA annotation of GRCm38

  51460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Mras

Human
homologs
Human Homolog MRAS, muscle RAS oncogene homolog
NCBI Gene ID 22808
neXtProt AC  NX_O14807
Human Synonyms  M-RAs, RRAS3, R-RAS3
Human Chr (Location)  3q22.3; chr3:138347648-138405535 (+)  GRCh38
Alleles
and
phenotypes
All alleles(186) : Gene trapped(183) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process GTP catabolic process, signal transduction, ...
Component extracellular vesicular exosome, membrane, ...
Function GTP binding, GTP-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (26)   
Theiler Stages: 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 25
Northern blot 4
Western blot 16
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029468 (Evidence)
Ensembl Gene ModelENSMUSG00000032470 (Evidence)
Entrez Gene17532 (Evidence)
UniGene2045
DFCITC1582900, TC1583363, TC1612190, TC1641337
DoTSDT.110628427, DT.526751, DT.531223, DT.94238967
NIA Mouse Gene IndexU031234
PDB1X1R, 1X1S, 3KKO, 3KKP, 3KKQ, 3PIR, 3PIT
Consensus CDS ProjectCCDS23433.1
International Mouse Knockout Project StatusMras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029468 VEGA Gene Model | MGI Sequence Detail 51460 C57BL/6J ±  kb
transcript OTTMUST00000073013 VEGA | MGI Sequence Detail 4036 Not Applicable 
polypeptide OTTMUSP00000037738 VEGA | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(274 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000010559 ras-related protein M-Ras
References (Earliest) J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(46)
Other
accession IDs
MGI:1920303, MGI:2143025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory