Mras MGI Mouse Gene Detail - MGI:1100856 - muscle and microspikes RAS

Symbol

Mras
Name

muscle and microspikes RAS
Synonyms

2900078C09Rik

Feature Type

protein coding gene
IDs

MGI:1100856
NCBI Gene: 17532
Gene Overview

MyGene.info: MRAS
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr9:99385420-99436964 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.63 cM
Mapping Data

3 experiments

SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100856	protein coding gene	Chr9:99385420-99437381 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035169	protein coding gene	Chr9:100753924-100808139 (-)
A/J	MGP_AJ_G0035150	protein coding gene	Chr9:97194542-97247043 (-)
AKR/J	MGP_AKRJ_G0035082	protein coding gene	Chr9:99569931-99621754 (-)
BALB/cJ	MGP_BALBcJ_G0035143	protein coding gene	Chr9:96877152-96929216 (-)
C3H/HeJ	MGP_C3HHeJ_G0034853	protein coding gene	Chr9:99958187-100010827 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035663	protein coding gene	Chr9:103636137-103692572 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032562	protein coding gene	Chr9:94934121-94985695 (-)
CAST/EiJ	MGP_CASTEiJ_G0034164	protein coding gene	Chr9:99777838-99836373 (-)
CBA/J	MGP_CBAJ_G0034821	protein coding gene	Chr9:107189197-107243527 (-)
DBA/2J	MGP_DBA2J_G0034983	protein coding gene	Chr9:96707006-96759317 (-)
FVB/NJ	MGP_FVBNJ_G0034931	protein coding gene	Chr9:95525377-95579237 (-)
LP/J	MGP_LPJ_G0035059	protein coding gene	Chr9:100998976-101052450 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034970	protein coding gene	Chr9:109106746-109164669 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035685	protein coding gene	Chr9:99816084-99870547 (-)
PWK/PhJ	MGP_PWKPhJ_G0033871	protein coding gene	Chr9:96924052-96976819 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033706	protein coding gene	Chr9:99876997-99934988 (-)
WSB/EiJ	MGP_WSBEiJ_G0034284	protein coding gene	Chr9:99689676-99744269 (-)

Human Ortholog

MRAS, muscle RAS oncogene homolog

Vertebrate Orthologs

10

Human Ortholog

MRAS, muscle RAS oncogene homolog
Orthology source: HomoloGene, HGNC
Synonyms

M-RAs, RRAS3, R-RAS3
Links

HGNC:7227

NCBI Gene ID: 22808

neXtProt AC: NX_O14807

UniProt: O14807
Chr Location

3q22.3; chr3:138347648-138405535 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7424
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MRAS
Protein SuperFamily

ras protein
Gene Tree

Mras

less

Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

187
Chemically induced (other)

1
Gene trapped

183
Targeted

3
Genomic Mutations

1 involving Mras
Incidental Mutations

APF
Find Mice (IMSR)

89 strains or lines available

Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.

less

All GO Annotations

10
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

45
Tissues

26
cDNA Data

50
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mras

less

Mras interacts with 316 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

less

All Sequences

51
RefSeq

4
UniProt

4
CCDS

CCDS23433.1
UniGene

2045

Ensembl

ENSMUSG00000032470 (Evidence)
NCBI Gene

17532

			Length	Strain/Species	Flank
genomic	17532	NCBI Gene Model \| MGI Sequence Detail	51545	C57BL/6J	± kb
transcript	NM_008624	RefSeq \| MGI Sequence Detail	4058	C57BL/6
polypeptide	O08989	UniProt \| EBI \| MGI Sequence Detail	208	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000010559 ras-related protein M-Ras

(term hierarchy)
PDB

1X1R, 1X1S, 3KKO, 3KKP, 3KKQ, 3PIR, 3PIT
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR020849 Small GTPase superfamily, Ras-type

IPR005225 Small GTP-binding protein domain

less

All nucleic 51

cDNA 51

Microarray probesets 5

less

MGI:1920303, MGI:2143025

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 15
Earliest

J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
Latest

J:263229 Sanz-Rodriguez M, et al., R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System. J Neurosci. 2018 May 30;38(22):5096-5110

TSS for Mras:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91070	Chr9:99437555-99437564 (-)	-596 bp
Tssr91069	Chr9:99436749-99436760 (-)	209 bp
Tssr91068	Chr9:99436687-99436733 (-)	254 bp
Tssr91067	Chr9:99436647-99436681 (-)	300 bp
Tssr91066	Chr9:99436629-99436641 (-)	329 bp
Tssr91065	Chr9:99436613-99436622 (-)	346 bp
Tssr91064	Chr9:99436583-99436609 (-)	368 bp
Tssr91063	Chr9:99436548-99436562 (-)	409 bp
Tssr91062	Chr9:99436470-99436533 (-)	462 bp
Tssr91061	Chr9:99426132-99426134 (-)	10,831 bp
Tssr91059	Chr9:99420370-99420394 (-)	16,582 bp
Tssr91058	Chr9:99420322-99420334 (-)	16,636 bp
Tssr91057	Chr9:99420265-99420276 (-)	16,693 bp
Tssr91056	Chr9:99420247-99420257 (-)	16,712 bp
Tssr91055	Chr9:99411824-99411870 (-)	25,117 bp
Tssr91054	Chr9:99411194-99411240 (-)	25,747 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13