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Mras
Gene Detail
Symbol

Name
ID
Mras
muscle and microspikes RAS
MGI:1100856
Synonyms
2900078C09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:99385420-99437381 bp, - strand
From VEGA annotation of GRCm38

  51962 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MRAS
Protein SuperFamily: ras protein
Gene Tree: Mras

Human
homologs
MRAS, muscle RAS oncogene homolog
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 22808
neXtProt AC: NX_O14807

Human Synonyms: M-RAs, RRAS3, R-RAS3

Human Chr (Location): 3q22.3; chr3:138347648-138405535 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(186) : Gene trapped(183) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.
 
Interactions
Mras interacts with 316 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process signal transduction, small GTPase mediated signal transduction
Component extracellular exosome, membrane, ...
Function GTP binding, GTP-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 4
Western blot 16
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mras    NEW 
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029468 (Evidence)
Ensembl Gene Model ENSMUSG00000032470 (Evidence)
Entrez Gene 17532 (Evidence)
UniGene 2045
DFCI TC1641337, TC1583363, TC1612190, TC1582900
DoTS DT.94238967, DT.531223, DT.526751, DT.110628427
NIA Mouse Gene Index U031234
PDB 3PIT, 3PIR, 3KKQ, 3KKP, 3KKO, 1X1R, 1X1S
Consensus CDS Project CCDS23433.1
International Mouse Phenotyping Consortium Status Mras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029468 VEGA Gene Model | MGI Sequence Detail 51962 C57BL/6J ±  kb
transcript OTTMUST00000073013 VEGA | MGI Sequence Detail 4701 Not Applicable 
polypeptide OTTMUSP00000037738 VEGA | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000010559 ras-related protein M-Ras
References
(Earliest) J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(44)
Other
accession IDs
MGI:1920303, MGI:2143025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory