Mras MGI Mouse Gene Detail - MGI:1100856 - muscle and microspikes RAS

Mras Gene Detail

Symbol

Mras
Name

muscle and microspikes RAS
Synonyms

2900078C09Rik

Feature Type

protein coding gene
IDs

MGI:1100856
NCBI Gene: 17532
Gene Overview

MyGene.info: MRAS

Sequence Map

Chr9:99385420-99437381 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

51962 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.63 cM
Mapping Data

3 experiments

Human Ortholog

MRAS, muscle RAS oncogene homolog

Vertebrate Orthologs

10

Human Ortholog

MRAS, muscle RAS oncogene homolog
Orthology source: HomoloGene, HGNC
Synonyms

M-RAs, RRAS3, R-RAS3
Links

HGNC:7227

NCBI Gene ID: 22808

neXtProt AC: NX_O14807
Chr Location

3q22.3; chr3:138347648-138405535 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7424
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: MRAS
Protein SuperFamily

ras protein
Gene Tree

Mras

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

187
Chemically induced (other)

1
Gene trapped

183
Targeted

3
Genomic Mutations

1 involving Mras
Incidental Mutations

APF

Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.

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All GO Annotations

10
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

45
Tissues

26
cDNA Data

48
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

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Mras interacts with 316 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS23433.1
UniGene

2045

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029468	VEGA Gene Model \| MGI Sequence Detail	51962	C57BL/6J	± kb
transcript	OTTMUST00000073014	VEGA \| MGI Sequence Detail	1122	Not Applicable
polypeptide	OTTMUSP00000037739	VEGA \| MGI Sequence Detail	208	Not Applicable

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SNPs within 2kb

277 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000010559 ras-related protein M-Ras
PDB

1X1R, 1X1S, 3KKO, 3KKP, 3KKQ, 3PIR, 3PIT
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase superfamily

IPR020849 Small GTPase superfamily, Ras type

IPR005225 Small GTP-binding protein domain

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All nucleic 49

cDNA 49

Microarray probesets 5

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MGI:1920303, MGI:2143025

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 14
Earliest

J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
Latest

J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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