Mras
Gene Detail

Symbol

Name
ID

Mras
muscle and microspikes RAS
MGI:1100856

Synonyms

2900078C09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9
51.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:99385420-99437381 bp, - strand From VEGA annotation of GRCm38   51962 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Mras

Human
homologs

Human Homolog		MRAS, muscle RAS oncogene homolog
NCBI Gene ID		22808
neXtProt AC		NX_O14807
Human Synonyms		M-RAs, RRAS3, R-RAS3
Human Chr (Location)		3q22.3; chr3:138347648-138405535 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(186) : Gene trapped(183) Targeted(3)
Incidental mutations (data from APF )
 

Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.

 

Interactions

Mras interacts with 317 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (10 annotations)

Process	signal transduction, small GTPase mediated signal transduction
Component	extracellular vesicular exosome, membrane, ...
Function	GTP binding, GTP-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (45)    Tissues (26)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	25
Northern blot	4
Western blot	16

cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(49) cDNA(49)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000029468 (Evidence)
Ensembl Gene Model	ENSMUSG00000032470 (Evidence)
Entrez Gene	17532 (Evidence)
UniGene	2045
DFCI	TC1641337, TC1612190, TC1583363, TC1582900
DoTS	DT.531223, DT.526751, DT.110628427, DT.94238967
NIA Mouse Gene Index	U031234
PDB	3PIT, 3PIR, 3KKP, 3KKQ, 1X1S, 1X1R, 3KKO
Consensus CDS Project	CCDS23433.1
International Mouse Knockout Project Status	Mras

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029468	VEGA Gene Model | MGI Sequence Detail	51962	C57BL/6J
transcript	OTTMUST00000073013	VEGA | MGI Sequence Detail	4701	Not Applicable
polypeptide	OTTMUSP00000037738	VEGA | MGI Sequence Detail	208	Not Applicable

All sequences(52) RefSeq(4) UniProt(4)

Polymorphisms

SNPs within 2kb(277 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR020849	Small GTPase superfamily, Ras type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000010559	ras-related protein M-Ras

References

(Earliest) J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(46)

Other
accession IDs

MGI:1920303, MGI:2143025