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Mras Gene Detail
Summary
  • Symbol
    Mras
  • Name
    muscle and microspikes RAS
  • Synonyms
    2900078C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100856
    NCBI Gene: 17532
  • Gene Overview
    MyGene.info: MRAS
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:99385420-99436964 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100856
 protein coding gene Chr9:99385420-99437381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035169
 protein coding gene Chr9:100753924-100808139 (-)
A/J MGP_AJ_G0035150
 protein coding gene Chr9:97194542-97247043 (-)
AKR/J MGP_AKRJ_G0035082
 protein coding gene Chr9:99569931-99621754 (-)
BALB/cJ MGP_BALBcJ_G0035143
 protein coding gene Chr9:96877152-96929216 (-)
C3H/HeJ MGP_C3HHeJ_G0034853
 protein coding gene Chr9:99958187-100010827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035663
 protein coding gene Chr9:103636137-103692572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032562
 protein coding gene Chr9:94934121-94985695 (-)
CAST/EiJ MGP_CASTEiJ_G0034164
 protein coding gene Chr9:99777838-99836373 (-)
CBA/J MGP_CBAJ_G0034821
 protein coding gene Chr9:107189197-107243527 (-)
DBA/2J MGP_DBA2J_G0034983
 protein coding gene Chr9:96707006-96759317 (-)
FVB/NJ MGP_FVBNJ_G0034931
 protein coding gene Chr9:95525377-95579237 (-)
LP/J MGP_LPJ_G0035059
 protein coding gene Chr9:100998976-101052450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034970
 protein coding gene Chr9:109106746-109164669 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035685
 protein coding gene Chr9:99816084-99870547 (-)
PWK/PhJ MGP_PWKPhJ_G0033871
 protein coding gene Chr9:96924052-96976819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033706
 protein coding gene Chr9:99876997-99934988 (-)
WSB/EiJ MGP_WSBEiJ_G0034284
 protein coding gene Chr9:99689676-99744269 (-)



Homology
more
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M-RAs, NS11, RRAS3, R-RAS3
  • Links
    NCBI Gene ID: 22808
    neXtProt AC: NX_O14807
    UniProt: O14807

  • Chr Location
    3q22.3; chr3:138347648-138405535 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    45
  • Tissues
    26
  • cDNA Data
    50
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17532 NCBI Gene Model | MGI Sequence Detail 51545 C57BL/6J ±  kb
transcript NM_008624 RefSeq | MGI Sequence Detail 4058 C57BL/6  
polypeptide O08989 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 5
Other
Accession IDs
less
MGI:1920303, MGI:2143025
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
  • Latest
    J:263229 Sanz-Rodriguez M, et al., R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System. J Neurosci. 2018 May 30;38(22):5096-5110
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory