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Mras Gene Detail
Summary
  • Symbol
    Mras
  • Name
    muscle and microspikes RAS
  • Synonyms
    2900078C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100856
    NCBI Gene: 17532
Location & Maps
more
  • Sequence Map
    Chr9:99385420-99437381 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51962 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRAS, muscle RAS oncogene homolog
    Orthology source: HomoloGene
  • Synonyms
    M-RAs, RRAS3, R-RAS3
  • Links
    NCBI Gene ID: 22808
    neXtProt AC: NX_O14807

  • Chr Location
    3q22.3; chr3:138347648-138405535 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    187
  • Chemically induced (other)
    1
  • Gene trapped
    183
  • Targeted
    3
  • Genomic Mutations
    1 involving Mras
  • Incidental Mutations
    APF
Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029468 VEGA Gene Model | MGI Sequence Detail 51962 C57BL/6J ±  kb
transcript OTTMUST00000073013 VEGA | MGI Sequence Detail 4701 Not Applicable  
polypeptide OTTMUSP00000037738 VEGA | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    277 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 5
Other
Accession IDs
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MGI:1920303, MGI:2143025
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:36917 Kogerman P, et al., CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene. J Cell Physiol. 1996 Nov;169(2):341-9
  • Latest
    J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory