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Elavl1
Gene Detail
Symbol

Name
ID
Elavl1
ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
MGI:1100851
Synonyms
2410055N02Rik, Hua, HuR, W91709
Feature Type
protein coding gene
Genetic Map
Chromosome 8
2.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:4284782-4325100 bp, - strand
From Ensembl annotation of GRCm38

  40319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ELAVL1
Gene Tree: Elavl1

Human
homologs
ELAVL1, ELAV like RNA binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1994
neXtProt AC: NX_Q15717

Human Synonyms: ELAV1, Hua, HUR, MelG

Human Chr (Location): 19p13.2; chr19:7958573-8005645 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(36) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Elavl1 interacts with 445 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process 3'-UTR-mediated mRNA stabilization, mRNA stabilization, ...
Component cytoplasm, membrane, ...
Function AU-rich element binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (229)    Tissues (176)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 200
Northern blot 12
RT-PCR 10
cDNA source data(160)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase elavl1 ; ZFIN elavl1    NEW 
Molecular
reagents
All nucleic(164) cDNA(161) Primer pair(2) Other(1)
Microarray probesets(10)
Other database
links
Ensembl Gene Model ENSMUSG00000040028 (Evidence)
Entrez Gene 15568 (Evidence)
UniGene 119162
DFCI TC1707012, TC1659248, TC1665076, TC1644265, TC1617239, TC1595327, TC1572367
NIA Mouse Gene Index U029555, U185439
Consensus CDS Project CCDS22084.1
International Mouse Phenotyping Consortium Status Elavl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040028 Ensembl Gene Model | MGI Sequence Detail 40319 C57BL/6J ±  kb
transcript ENSMUST00000098950 Ensembl | MGI Sequence Detail 6030 Not Applicable 
polypeptide ENSMUSP00000096549 Ensembl | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR002343 Paraneoplastic encephalomyelitis antigen
InterPro IPR000504 RNA recognition motif domain
InterPro IPR006548 Splicing factor ELAV/HuD
Protein Ontology PR:000007016 ELAV-like protein 1
References
(Earliest) J:25196 Good PJ, A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4557-61
(Latest) J:216804 Chang SH, et al., ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18309-14
All references(87)
Other
accession IDs
MGI:1920936, MGI:2142902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory