About   Help   FAQ
Elavl1
Gene Detail
 Symbol
Name
ID
Elavl1
ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
MGI:1100851
Synonyms 2410055N02Rik, Hua, HuR, W91709
Feature Type protein coding gene
Genetic Map
Chromosome 8
2.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:4284782-4325100 bp, - strand
From NCBI annotation of GRCm38

  40319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Elavl1

Human
homologs
Human Homolog ELAVL1, ELAV like RNA binding protein 1
NCBI Gene ID 1994
neXtProt AC  NX_Q15717
Human Synonyms  ELAV1, Hua, HUR, MelG
Human Chr (Location)  19p13.2; chr19:7958573-8005645 (-)  GRCh38
Alleles
and
phenotypes
All alleles(46) : Gene trapped(36) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Placental defects result in mid-gestational embryonic lethality for homozygote null embryos. Mice heterozygous for a knock-out allele exhibit decreased hematopoeitic cells and increased sensitivity of bone marrow, spleen, and thymus cells to whole body irradiation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process 3'-UTR-mediated mRNA stabilization, mRNA stabilization, ...
Component cytoplasm, membrane, ...
Function AU-rich element binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (236)    Tissues (173)    Images (27)
Theiler Stages: 1, 2, 3, 4, 5, 10, 17, 18, 19, 20, 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 200
Northern blot 12
RT-PCR 17
cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(164) cDNA(161) Primer pair(2) Other(1)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000040028 (Evidence)
Entrez Gene15568 (Evidence)
UniGene119162
DFCITC1572367, TC1595327, TC1617239, TC1644265, TC1659248, TC1665076, TC1707012
NIA Mouse Gene IndexU029555, U185439
Consensus CDS ProjectCCDS22084.1
International Mouse Knockout Project StatusElavl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15568 NCBI Gene Model | MGI Sequence Detail 40319 C57BL/6J ±  kb
transcript NM_010485 RefSeq | MGI Sequence Detail 6030 C57BL/6 
polypeptide P70372 UniProt | EBI | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(4) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR002343 Paraneoplastic encephalomyelitis antigen
InterPro IPR000504 RNA recognition motif domain
InterPro IPR006548 Splicing factor ELAV/HuD
Protein Ontology PR:000007016 ELAV-like protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:25196 Good PJ, A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4557-61
(Latest) J:209128 Gubin MM, et al., Conditional knockout of the RNA-binding protein HuR in CD4(+) T cells reveals a gene dosage effect on cytokine production. Mol Med. 2014;20:93-108
All references(84)
Other
accession IDs
MGI:1920936, MGI:2142902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory