Capn6
Gene Detail

Symbol Name ID

Capn6 calpain 6 MGI:1100850

Feature Type

protein coding gene

Genetic Map

Chromosome X

64.83 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:143802231-143827414 bp, - strand From VEGA annotation of GRCm38   25184 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Capn6

Human homologs

Human Homolog		CAPN6, calpain 6
NCBI Gene ID		827
neXtProt AC		NX_Q9Y6Q1
Human Synonyms		CalpM, CANPX, CAPNX, DJ914P14.1
Human Chr (Location)		Xq23; chrX:110488327-110513774 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	microtubule bundle formation, proteolysis, ...
Component	cytoplasm, cytoskeleton, ...
Function	calcium-dependent cysteine-type endopeptidase activity, microtubule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (33)    Images (15)
Theiler Stages: 17, 19, 20, 24, 28

Assay Type	Results
RNA in situ	46

cDNA source data(83)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(84) Genomic(1) cDNA(83)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000018841 (Evidence)
Ensembl Gene Model	ENSMUSG00000067276 (Evidence)
Entrez Gene	12338 (Evidence)
UniGene	30290
DFCI	TC1578099, TC1607958
DoTS	DT.491301, DT.94210312
NIA Mouse Gene Index	U039757
Consensus CDS Project	CCDS30455.1
International Mouse Knockout Project Status	Capn6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018841	VEGA Gene Model | MGI Sequence Detail	25184	C57BL/6J
transcript	OTTMUST00000045333	VEGA | MGI Sequence Detail	3561	Not Applicable
polypeptide	OTTMUSP00000020393	VEGA | MGI Sequence Detail	641	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR001300	Peptidase C2, calpain, catalytic domain
InterPro	IPR022683	Peptidase C2, calpain, domain III
InterPro	IPR022684	Peptidase C2, calpain family
InterPro	IPR022682	Peptidase C2, calpain, large subunit, domain III
Protein Ontology	PR:000005018	calpain-6

References

(Earliest) J:43496 Dear N, et al., A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)