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Kpna4 Gene Detail
Summary
  • Symbol
    Kpna4
  • Name
    karyopherin (importin) alpha 4
  • Synonyms
    1110058D08Rik, importin alpha 3, IPOA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100848
    NCBI Gene: 16649
  • Gene Overview
    MyGene.info: KPNA4
Location & Maps
more
  • Sequence Map
    Chr3:69067149-69127113 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59965 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.18 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KPNA4, karyopherin subunit alpha 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KPNA4, karyopherin subunit alpha 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IPOA3, QIP1, SRP3
  • Links
    NCBI Gene ID: 3840
    neXtProt AC: NX_O00629

  • Chr Location
    3q25.33; chr3:160494995-160565588 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Kpna4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029117 VEGA Gene Model | MGI Sequence Detail 59965 C57BL/6J ±  kb
transcript OTTMUST00000072198 VEGA | MGI Sequence Detail 8819 Not Applicable  
polypeptide OTTMUSP00000037101 VEGA | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    274 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    cDNA 92
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:1926016
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
  • Latest
    J:228044 Mihalas BP, et al., Changing expression and subcellular distribution of karyopherins during murine oogenesis. Reproduction. 2015 Dec;150(6):485-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory