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Mid1 Gene Detail
Summary
  • Symbol
    Mid1
  • Name
    midline 1
  • Synonyms
    61B3-R, DXHXS1141, Fxy, Trim18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100537
    NCBI Gene: 17318
  • Gene Overview
    MyGene.info: MID1
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:169685199-169990798 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 79.19 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    800 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100537
protein coding gene ChrX:169685199-170005736 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035486
protein coding gene Chr9:126981407-127002525 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0036243
protein coding gene ChrX:165212570-165276387 (+)
C3H/HeJ MGP_C3HHeJ_G0035949
protein coding gene ChrX:168226946-168544232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036765
protein coding gene ChrX:172768024-173079336 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033586
protein coding gene ChrX:157937027-158034255 (+)
CAST/EiJ MGP_CASTEiJ_G0035237
protein coding gene ChrX:147353511-147355969 (-)
CBA/J MGP_CBAJ_G0035924
protein coding gene ChrX:177985063-178099070 (+)
DBA/2J MGP_DBA2J_G0036089
protein coding gene ChrX:165785932-166088528 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0036175
protein coding gene ChrX:169188704-169302911 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036804
protein coding gene ChrX:167386190-167693864 (+)
PWK/PhJ MGP_PWKPhJ_G0034935
protein coding gene ChrX:143758609-144060370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034755
protein coding gene ChrX:147920476-148039995 (+)
WSB/EiJ MGP_WSBEiJ_G0035373
protein coding gene ChrX:165422235-165503361 (+)



Homology
more
  • Human Ortholog
    MID1, midline 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MID1, midline 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY
  • Links
    NCBI Gene ID: 4281
    neXtProt AC: NX_O15344
    UniProt: O15344

  • Chr Location
    Xp22.2; chrX:10445310-11111264 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7837
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MID1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Mid1 mouse models; 1 with human MID1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for disruptions in this gene have a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17318 NCBI Gene Model | MGI Sequence Detail 305600 C57BL/6J ±  kb
    transcript NM_001290505 RefSeq | MGI Sequence Detail 3938 C57BL/6  
    polypeptide O70583 UniProt | EBI | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 3
      cDNA 21
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1345953
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:43704 Palmer S, et al., A gene spans the pseudoautosomal boundary in mice. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12030-5
    • Latest
      J:244447 Li B, et al., Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome. Mol Genet Genomic Med. 2016 Jan;4(1):95-105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory