Mid1
Gene Detail

Symbol Name ID

Mid1 midline 1 MGI:1100537

Synonyms

61B3-R, DXHXS1141, Fxy, Trim18

Feature Type

protein coding gene

Genetic Map

Chromosome X

79.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

ChrX:169685199-169990798 bp, + strand From VEGA annotation of GRCm38   305600 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: midline
Gene Tree: Mid1

Human homologs

Human Homolog		MID1, midline 1 (Opitz/BBB syndrome)
NCBI Gene ID		4281
neXtProt AC		NX_O15344
Human Synonyms		BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY
Human Chr (Location)		Xp22; chrX:10413350-10851809 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MID1

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Mice homozygous or hemizygous for disruptions in this gene have a normal phenotype.

 
Human Diseases Modeled Using Mouse Mid1 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	negative regulation of microtubule depolymerization, positive regulation of stress-activated MAPK cascade
Component	cytoplasm, cytoplasmic microtubule, ...
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (176)    Tissues (96)    Images (29)
Theiler Stages: 10, 15, 16, 17, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	145
Northern blot	9
RT-PCR	22

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(3) cDNA(19) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000019599 (Evidence)
Ensembl Gene Model	ENSMUSG00000035299 (Evidence)
Entrez Gene	17318 (Evidence)
EC	6.3.2.-
Consensus CDS Project	CCDS41215.1
International Mouse Knockout Project Status	Mid1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019599	VEGA Gene Model | MGI Sequence Detail	305600	C57BL/6J
transcript	OTTMUST00000046822	VEGA | MGI Sequence Detail	3753	Not Applicable
polypeptide	OTTMUSP00000021179	VEGA | MGI Sequence Detail	680	Not Applicable

All sequences(79) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(3) : SNPs(952 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001870	B30.2/SPRY domain
InterPro	IPR003649	B-box, C-terminal
InterPro	IPR003879	Butyrophylin-like
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR017903	COS domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003877	SPla/RYanodine receptor SPRY
InterPro	IPR018355	SPla/RYanodine receptor subgroup
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000010406	midline-1

References

(Earliest) J:43704 Palmer S, et al., A gene spans the pseudoautosomal boundary in mice. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12030-5
(Latest) J:184831 Uchibe K, et al., Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
All references(43)

Other accession IDs

MGI:1345953