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Myt1
Gene Detail
Symbol

Name
ID
Myt1
myelin transcription factor 1
MGI:1100535
Synonyms
mKIAA0835, Nzf2, NZF-2a, NZF-2b, Nztf2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:181763332-181827797 bp, + strand
From VEGA annotation of GRCm38

  64466 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3332  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYT1
Gene Tree: Myt1

Human
homologs
MYT1, myelin transcription factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4661
neXtProt AC: NX_Q01538

Human Synonyms: C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A

Human Chr (Location): 20q13.33; chr20:64164474-64242253 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones.
 
Interactions
Myt1 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell differentiation, cellular glucose homeostasis, ...
Component cell, cytoplasm, ...
Function DNA binding, enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (189)    Tissues (83)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
In situ reporter (knock in) 3
Northern blot 6
RT-PCR 41
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYT1 ; Xenbase myt1 ; ZFIN myt1a    NEW 
Molecular
reagents
All nucleic(22) cDNA(15) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016812 (Evidence)
Ensembl Gene Model ENSMUSG00000010505 (Evidence)
Entrez Gene 17932 (Evidence)
DFCI TC1581185, TC1621270, TC1629126, TC1675371
DoTS DT.101204329, DT.101372333, DT.110662465, DT.110662472, DT.91310671, DT.97387028, DT.99698273
NIA Mouse Gene Index U002992
PDB 2JX1, 2JYD, 2MF8
Consensus CDS Project CCDS17223.1, CCDS50856.1, CCDS50857.1
International Mouse Phenotyping Consortium Status Myt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016812 VEGA Gene Model | MGI Sequence Detail 64466 C57BL/6J ±  kb
transcript OTTMUST00000040832 VEGA | MGI Sequence Detail 5327 Not Applicable 
polypeptide OTTMUSP00000018260 VEGA | MGI Sequence Detail 1169 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(21) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013681 Myelin transcription factor 1
InterPro IPR002515 Zinc finger, C2HC-type
Protein Ontology PR:000010892 myelin transcription factor 1
References
(Earliest) J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
(Latest) J:207766 Matsushita F, et al., Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development. Dev Dyn. 2014 Apr;243(4):588-600
All references(55)
Other
accession IDs
MGD-MRK-38473, MGI:109428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory