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Nmbr Gene Detail
Summary
  • Symbol
    Nmbr
  • Name
    neuromedin B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100525
    NCBI Gene: 18101
  • Gene Overview
    MyGene.info: NMBR
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:14760289-14770556 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 5.50 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    431 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100525
protein coding gene Chr10:14705591-14770850 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017029
protein coding gene Chr10:12204058-12269233 (+)
A/J MGP_AJ_G0017007
protein coding gene Chr10:11722723-11788167 (+)
AKR/J MGP_AKRJ_G0016971
protein coding gene Chr10:11973955-12039658 (+)
BALB/cJ MGP_BALBcJ_G0016965
protein coding gene Chr10:11749531-11814135 (+)
C3H/HeJ MGP_C3HHeJ_G0016790
protein coding gene Chr10:12166601-12239549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017427
protein coding gene Chr10:12495558-12562129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015132
protein coding gene Chr10:10944847-11006106 (+)
CAST/EiJ MGP_CASTEiJ_G0016372
protein coding gene Chr10:12039742-12103467 (+)
CBA/J MGP_CBAJ_G0016762
protein coding gene Chr10:12984581-13069829 (+)
DBA/2J MGP_DBA2J_G0016870
protein coding gene Chr10:11654165-11716048 (+)
FVB/NJ MGP_FVBNJ_G0016865
protein coding gene Chr10:11447697-11511813 (+)
LP/J MGP_LPJ_G0016945
protein coding gene Chr10:12041603-12123277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016895
protein coding gene Chr10:12862243-12952131 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017465
protein coding gene Chr10:11899114-11965059 (+)
PWK/PhJ MGP_PWKPhJ_G0016157
protein coding gene Chr10:11482434-11546682 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015940
protein coding gene Chr10:12024122-12095618 (+)
WSB/EiJ MGP_WSBEiJ_G0016434
protein coding gene Chr10:11952774-12024690 (+)



Homology
more
  • Human Ortholog
    NMBR, neuromedin B receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NMBR, neuromedin B receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BB1, BB1R, NMB-R
  • Links
    NCBI Gene ID: 4829
    neXtProt AC: NX_P28336
    UniProt: P28336

  • Chr Location
    6q24.1; chr6:142074484-142147205 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a 50% reduction in the thermoregulatory response to neuromedin B as well as impaired maternal behavior in response to restraint-induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18101 NCBI Gene Model | MGI Sequence Detail 10268 C57BL/6J ±  kb
transcript NM_008703 RefSeq | MGI Sequence Detail 1173 C57BL/6  
polypeptide O54799 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143902
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:41803 Ohki-Hamazaki H, et al., Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 1997 Jul 11;762(1-2):165-72
  • Latest
    J:253572 Wan L, et al., Distinct roles of NMB and GRP in itch transmission. Sci Rep. 2017 Nov 13;7(1):15466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory