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Dr1 Gene Detail
Summary
  • Symbol
    Dr1
  • Name
    down-regulator of transcription 1
  • Synonyms
    1700121L09Rik, Dr1l, NC2, NC2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100515
    NCBI Gene: 13486
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108416763-108428387 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 52.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100515
 protein coding gene Chr5:108416763-108428392 (+)
129S1/SvImJ ENSMUSG00200020497
 protein coding gene Chr5:102166170-102177814 (+)
A/J ENSMUSG00195034217
 protein coding gene Chr5:101622949-101634596 (+)
AKR/J ENSMUSG00220049899
 protein coding gene Chr5:101172711-101184342 (+)
BALB/cJ ENSMUSG00180033281
 protein coding gene Chr5:101775792-101787440 (+)
C3H/HeJ ENSMUSG00175039645
 protein coding gene Chr5:103811741-103823401 (+)
C57BL/6NJ ENSMUSG00215017054
 protein coding gene Chr5:101819716-101831344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027516
 protein coding gene Chr5:101160154-101171754 (+)
CAST/EiJ ENSTCUG00005022517
 protein coding gene Chr5:101055353-101066982 (+)
CBA/J ENSMUSG00210043599
 protein coding gene Chr5:102569300-102580961 (+)
DBA/2J ENSMUSG00185045860
 protein coding gene Chr5:105479193-105490839 (+)
FVB/NJ ENSMUSG00205036812
 protein coding gene Chr5:101491951-101503610 (+)
JF1/MsJ ENSUMUG00000011554
 protein coding gene Chr5:108540980-108552784 (+)
LP/J ENSMUSG00230031035
 protein coding gene Chr5:109707227-109718869 (+)
NOD/ShiLtJ ENSMUSG00190041302
 protein coding gene Chr5:101475379-101487025 (+)
NZO/HlLtJ ENSMUSG00225024849
 protein coding gene Chr5:117329089-117340733 (+)
PWK/PhJ ENSLUMG00010015304
 protein coding gene Chr5:100528659-100539245 (+)
SPRET/EiJ ENSMSPG00010039943
 protein coding gene Chr5:103626701-103637738 (+)
WSB/EiJ ENSIUOG00005043613
 protein coding gene Chr5:104198805-104210465 (+)



Homology
more
  • Human Ortholog
    DR1, down-regulator of transcription 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DR1, down-regulator of transcription 1
  • Synonyms
    NC2, NC2B, NC2-BETA, NCB2
  • Links
    NCBI Gene ID: 1810
    UniProt: Q01658

  • Chr Location
    1p22.1; chr1:93345907-93369493 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    67
  • cDNA Data
    139
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13486 NCBI Gene Model | MGI Sequence Detail 11625 C57BL/6J ±  kb
transcript NM_026106 RefSeq | MGI Sequence Detail 3080 ZRU/MplStud  
polypeptide Q91WV0 UniProt | EBI | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 142
    cDNA 141
    Primer pair 1
    Antibodies 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914612
References
more
  • Summaries
    All 55
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:344657 de Oliveira-Higa MA, et al., The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice. Behav Brain Res. 2023 Jun 30;452:114562
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory