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Dr1 Gene Detail
Summary
  • Symbol
    Dr1
  • Name
    down-regulator of transcription 1
  • Synonyms
    1700121L09Rik, Dr1l, NC2, NC2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100515
    NCBI Gene: 13486
  • Gene Overview
    MyGene.info: DR1
Location & Maps
more
  • Sequence Map
    Chr5:108268897-108280526 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 52.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DR1, down-regulator of transcription 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    DR1, down-regulator of transcription 1
    Orthology source: HomoloGene
  • Synonyms
    NC2, NC2B, NC2-BETA
  • Links
    NCBI Gene ID: 1810
    neXtProt AC: NX_Q01658

  • Chr Location
    1p22.1; chr1:93345921-93362592 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dr1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028923 VEGA Gene Model | MGI Sequence Detail 11630 C57BL/6J ±  kb
transcript OTTMUST00000071679 VEGA | MGI Sequence Detail 3085 Not Applicable  
polypeptide OTTMUSP00000036779 VEGA | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006685 protein Dr1
  • InterPro Domains
    IPR009072 Histone-fold
    IPR003958 Transcription factor CBF/NF-Y/archaeal histone domain
Molecular
Reagents
less
  • All nucleic 141
    cDNA 140
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914612
References
more
  • Summaries
    All 40
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:38336 Purrello M, et al., Genomic localization of the human gene encoding Dr1, a negative modulator of transcription of class II and class III genes. Cytogenet Cell Genet. 1996;75(2-3):186-9
  • Latest
    J:210983 Chang AC, et al., A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 2014 Jul;243(7):894-905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory