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Kcnk3
Gene Detail
 Symbol
Name
ID
Kcnk3
potassium channel, subfamily K, member 3
MGI:1100509
Synonyms cTBAK-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
16.68 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:30588170-30625270 bp, + strand
From NCBI annotation of GRCm38

  37101 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk3

Human
homologs
Human Homolog KCNK3, potassium channel, subfamily K, member 3
NCBI Gene ID 3777
neXtProt AC  NX_O14649
Human Synonyms  K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1
Human Chr (Location)  2p23; chr2:26692713-26731198 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNK3
Alleles
and
phenotypes
All alleles(9) : Targeted(4) Gene trapped(5)
 
Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons.
 
Human Diseases Modeled Using Mouse Kcnk3 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular response to hypoxia, ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function ion channel activity, open rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (15)   
Theiler Stages: 2, 3, 4, 5, 25, 28
Assay TypeResults
Immunohistochemistry 3
RT-PCR 24
cDNA source data(27)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000049265 (Evidence)
Entrez Gene16527 (Evidence)
UniGene439936
DFCITC1584070, TC1598235
DoTSDT.529523, DT.87068660
NIA Mouse Gene IndexU161083
Consensus CDS ProjectCCDS19160.1
International Mouse Knockout Project StatusKcnk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16527 NCBI Gene Model | MGI Sequence Detail 37101 C57BL/6J ±  kb
transcript NM_010608 RefSeq | MGI Sequence Detail 3810 C57BL/6 
polypeptide O35111 UniProt | EBI | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR005406 Two pore domain potassium channel, TASK-1
InterPro IPR003092 Two pore domain potassium channel, TASK family
Protein Ontology PR:000002076 potassium channel subfamily K member 3
Graphical View of Protein Domain Structure
References (Earliest) J:42969 Duprat F, et al., TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71
(Latest) J:197938 Hao J, et al., Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron. 2013 Mar 6;77(5):899-914
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory