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Kcnk3 Gene Detail
Summary
  • Symbol
    Kcnk3
  • Name
    potassium channel, subfamily K, member 3
  • Synonyms
    cTBAK-1, Task-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100509
    NCBI Gene: 16527
  • Gene Overview
    MyGene.info: KCNK3
Location & Maps
more
  • Sequence Map
    Chr5:30588170-30625271 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37102 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.68 cM, cytoband B
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    KCNK3, potassium two pore domain channel subfamily K member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNK3, potassium two pore domain channel subfamily K member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1
  • Links
    NCBI Gene ID: 3777
    neXtProt AC: NX_O14649

  • Chr Location
    2p23; chr2:26692713-26731198 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kcnk3 mouse models; 1 with human KCNK3 associations

Human Disease Mouse Models
       Glucocorticoid-Remediable Aldosteronism; GRA   OMIM: 103900 View 2 models
       Pulmonary Hypertension, Primary, 4; PPH4   OMIM: 615344
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    7 involving Kcnk3
  • Incidental Mutations
Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054481 VEGA Gene Model | MGI Sequence Detail 37102 C57BL/6J ±  kb
transcript OTTMUST00000135096 VEGA | MGI Sequence Detail 3811 Not Applicable  
polypeptide OTTMUSP00000071558 VEGA | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002076 potassium channel subfamily K member 3
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR005406 Potassium channel subfamily K member 3
    IPR003280 Two pore domain potassium channel
    IPR003092 Two pore domain potassium channel, TASK family
Molecular
Reagents
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  • All nucleic 35
    Genomic 1
    cDNA 29
    Primer pair 4
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 5
    Phenotypes 45
  • Earliest
    J:42969 Duprat F, et al., TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71
  • Latest
    J:231854 Dadi PK, et al., TASK-1 Potassium Channels Limit Pancreatic alpha-Cell Calcium Influx and Glucagon Secretion. Mol Endocrinol. 2015 May;29(5):777-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory