Kcnk3
Gene Detail

Symbol Name ID

Kcnk3 potassium channel, subfamily K, member 3 MGI:1100509

Synonyms

cTBAK-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

16.68 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:30588170-30625270 bp, + strand From NCBI annotation of GRCm38   37101 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk3

Human homologs

Human Homolog		KCNK3, potassium channel, subfamily K, member 3
NCBI Gene ID		3777
neXtProt AC		NX_O14649
Human Synonyms		K2p3.1, OAT1, TASK, TASK-1, TBAK1
Human Chr (Location)		2p23; chr2:26915581-26954066 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons.

 
Human Diseases Modeled Using Mouse Kcnk3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cellular response to hypoxia, ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	open rectifier potassium channel activity, potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (15)   
Theiler Stages: 2, 3, 4, 5, 25, 28

Assay Type	Results
Immunohistochemistry	3
RT-PCR	24

cDNA source data(27)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(1) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000049265 (Evidence)
Entrez Gene	16527 (Evidence)
UniGene	439936
DFCI	TC1584070, TC1598235
DoTS	DT.529523, DT.87068660
NIA Mouse Gene Index	U161083
Consensus CDS Project	CCDS19160.1
International Mouse Knockout Project Status	Kcnk3

Sequences

Length	Strain/Species
genomic	16527	NCBI Gene Model | MGI Sequence Detail	37101	C57BL/6J
transcript	NM_010608	RefSeq | MGI Sequence Detail	3810	C57BL/6
polypeptide	O35111	UniProt | EBI | MGI Sequence Detail	409	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013099	Ion transport 2
InterPro	IPR003280	Two pore domain potassium channel
InterPro	IPR005406	Two pore domain potassium channel, TASK-1
InterPro	IPR003092	Two pore domain potassium channel, TASK family
InterPro	IPR022306	Two pore domain potassium channel, TASK/TWIK
Protein Ontology	PR:000002076	potassium channel subfamily K member 3

Graphical View of Protein Domain Structure

References

(Earliest) J:42969 Duprat F, et al., TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71
(Latest) J:188335 El Wakil A, et al., Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. Hum Mol Genet. 2012 Nov 15;21(22):4922-9
All references(49)