About   Help   FAQ
Kcnk3
Gene Detail
Symbol

Name
ID
Kcnk3
potassium channel, subfamily K, member 3
MGI:1100509
Synonyms
cTBAK-1, Task-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
16.68 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:30588170-30625270 bp, + strand
From NCBI annotation of GRCm38

  37101 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: KCNK3
Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk3

Human
homologs
KCNK3, potassium channel, two pore domain subfamily K, member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3777
neXtProt AC: NX_O14649

Human Synonyms: K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1

Human Chr (Location): 2p23; chr2:26692713-26731198 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNK3

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(5) Radiation induced(4) Targeted(5)
Genomic Mutations involving Kcnk3 (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons.
 
Human Diseases Modeled in Mice Using Kcnk3 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Kcnk3 interacts with 271 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RT-PCR 16
cDNA source data(27)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000049265 (Evidence)
Entrez Gene 16527 (Evidence)
UniGene 439936
DFCI TC1598235, TC1584070
DoTS DT.529523, DT.87068660
NIA Mouse Gene Index U161083
Consensus CDS Project CCDS19160.1
International Mouse Phenotyping Consortium Status Kcnk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16527 NCBI Gene Model | MGI Sequence Detail 37101 C57BL/6J ±  kb
transcript NM_010608 RefSeq | MGI Sequence Detail 3810 C57BL/6 
polypeptide O35111 UniProt | EBI | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR005406 Two pore domain potassium channel, TASK-1
InterPro IPR003092 Two pore domain potassium channel, TASK family
Protein Ontology PR:000002076 potassium channel subfamily K member 3
Graphical View of Protein Domain Structure
References
(Earliest) J:42969 Duprat F, et al., TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71
(Latest) J:218356 Dadi PK, et al., Pancreatic beta-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology. 2014 Oct;155(10):3757-68
All references(54)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory