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Brs3 Gene Detail
Summary
  • Symbol
    Brs3
  • Name
    bombesin-like receptor 3
  • Synonyms
    BRS-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100501
    NCBI Gene: 12209
  • Gene Overview
    MyGene.info: BRS3
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:57043074-57048758 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 30.78 cM, cytoband A7.1-A7.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100501
protein coding gene ChrX:57043074-57048758 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035743
protein coding gene ChrX:52360275-52365959 (+)
A/J MGP_AJ_G0035726
protein coding gene ChrX:52553657-52559341 (+)
AKR/J MGP_AKRJ_G0035646
protein coding gene ChrX:53952078-53957769 (+)
BALB/cJ MGP_BALBcJ_G0035713
protein coding gene ChrX:52009450-52015134 (+)
C3H/HeJ MGP_C3HHeJ_G0035415
protein coding gene ChrX:52887304-52892988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036242
protein coding gene ChrX:53744493-53750177 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033093
protein coding gene ChrX:51966274-51972017 (+)
CAST/EiJ MGP_CASTEiJ_G0034708
protein coding gene ChrX:38787823-38793519 (+)
CBA/J MGP_CBAJ_G0035390
protein coding gene ChrX:55321308-55326992 (+)
DBA/2J MGP_DBA2J_G0035544
protein coding gene ChrX:52135945-52141629 (+)
FVB/NJ MGP_FVBNJ_G0035494
protein coding gene ChrX:51733609-51739337 (+)
LP/J MGP_LPJ_G0035632
protein coding gene ChrX:52944457-52950141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035530
protein coding gene ChrX:56858451-56864142 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036258
protein coding gene ChrX:52391365-52397049 (+)
PWK/PhJ MGP_PWKPhJ_G0034404
protein coding gene ChrX:37057127-37062837 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034248
protein coding gene ChrX:39519788-39525472 (+)
WSB/EiJ MGP_WSBEiJ_G0034851
protein coding gene ChrX:51921532-51927217 (+)



Homology
more
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BB3, BB3R
  • Links
    NCBI Gene ID: 680
    neXtProt AC: NX_P32247
    UniProt: P32247

  • Chr Location
    Xq26.3; chrX:136487966-136492439 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit mild obesity, hypertension, impaired glucose metabolism, reduced metabolic rate, and hyperphagia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12209 NCBI Gene Model | MGI Sequence Detail 5685 C57BL/6J ±  kb
    transcript NM_009766 RefSeq | MGI Sequence Detail 2772 C57BL/6  
    polypeptide O54798 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 4
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:41803 Ohki-Hamazaki H, et al., Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 1997 Jul 11;762(1-2):165-72
    • Latest
      J:253437 Xiao C, et al., Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017 Nov;6(11):1540-1550

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory