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Brs3 Gene Detail
Summary
  • Symbol
    Brs3
  • Name
    bombesin-like receptor 3
  • Synonyms
    BRS-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100501
    NCBI Gene: 12209
  • Gene Overview
    MyGene.info: BRS3
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:57043074-57048758 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5685 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 30.78 cM, cytoband A7.1-A7.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BB3, BB3R
  • Links
    NCBI Gene ID: 680
    neXtProt AC: NX_P32247
    UniProt: P32247

  • Chr Location
    Xq26.3; chrX:136487966-136492439 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit mild obesity, hypertension, impaired glucose metabolism, reduced metabolic rate, and hyperphagia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017788 VEGA Gene Model | MGI Sequence Detail 5685 C57BL/6J ±  kb
    transcript OTTMUST00000043046 VEGA | MGI Sequence Detail 2772 Not Applicable  
    polypeptide OTTMUSP00000019345 VEGA | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      20 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 4
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:41803 Ohki-Hamazaki H, et al., Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 1997 Jul 11;762(1-2):165-72
    • Latest
      J:253437 Xiao C, et al., Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab. 2017 Nov;6(11):1540-1550

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory