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Skiv2l Gene Detail
Summary
  • Symbol
    Skiv2l
  • Name
    superkiller viralicidic activity 2-like (S. cerevisiae)
  • Synonyms
    4930534J06Rik, Ski2w
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099835
    NCBI Gene: 108077
  • Gene Overview
    MyGene.info: SKIV2L
Location & Maps
more
  • Sequence Map
    Chr17:34839228-34850210 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10983 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SKIV2L, Ski2 like RNA helicase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SKIV2L, Ski2 like RNA helicase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L1, THES2
  • Links
    NCBI Gene ID: 6499
    neXtProt AC: NX_Q15477

  • Chr Location
    6p21.33; chr6:31958804-31969755 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SKIV2L associations

Human Disease Mouse Models
       Trichohepatoenteric Syndrome 2; THES2   OMIM: 614602
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037261 VEGA Gene Model | MGI Sequence Detail 10983 C57BL/6J ±  kb
transcript OTTMUST00000096090 VEGA | MGI Sequence Detail 3951 Not Applicable  
polypeptide OTTMUSP00000053648 VEGA | MGI Sequence Detail 1244 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR016438 ATP-dependent RNA helicase Ski2
    IPR012961 ATP-dependent RNA helicase Ski2, C-terminal
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR025696 rRNA-processing arch domain
Molecular
Reagents
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  • All nucleic 119
    Genomic 1
    cDNA 118

    Microarray probesets 2
Other
Accession IDs
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MGI:2147055, MGI:2148488, MGI:2442955
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory