Skiv2l
Gene Detail

Symbol Name ID

Skiv2l superkiller viralicidic activity 2-like (S. cerevisiae) MGI:1099835

Synonyms

4930534J06Rik, Ski2w

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:34839228-34850210 bp, - strand From VEGA annotation of GRCm38   10983 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: antiviral helicase, SKI2 type
Gene Tree: Skiv2l

Human homologs

Human Homolog		SKIV2L, superkiller viralicidic activity 2-like (S. cerevisiae)
NCBI Gene ID		6499
neXtProt AC		NX_Q15477
Human Synonyms		170A, DDX13, HLP, SKI2, SKI2W, SKIV2, THES2
Human Chr (Location)		6p21; chr6:31926581-31937532 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SKIV2L

Alleles and phenotypes

All alleles(3) : Targeted(2) Transgenic(1)
 

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	metabolic process
Component	Ski complex
Function	ATP binding, helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(118)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(119) Genomic(1) cDNA(118)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037261 (Evidence)
Ensembl Gene Model	ENSMUSG00000040356 (Evidence)
Entrez Gene	108077 (Evidence)
UniGene	18845
DFCI	TC1572899, TC1595793, TC1608550, TC1714391, TC1736867
DoTS	DT.101231748, DT.101403119, DT.110559173, DT.491690, DT.94155704
NIA Mouse Gene Index	U037724
Consensus CDS Project	CCDS28661.1
International Mouse Knockout Project Status	Skiv2l

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037261	VEGA Gene Model | MGI Sequence Detail	10983	C57BL/6J
transcript	OTTMUST00000096090	VEGA | MGI Sequence Detail	3951	Not Applicable
polypeptide	OTTMUSP00000053648	VEGA | MGI Sequence Detail	1244	Not Applicable

All sequences(95) RefSeq(3) UniProt(8)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR012961	DSH, C-terminal
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR016438	RNA helicase, ATP-dependent, SK12/DOB1
InterPro	IPR025696	rRNA-processing arch domain
Protein Ontology	PR:000014907	helicase SKI2W

References

(Earliest) J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGI:2147055, MGI:2148488, MGI:2442955