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Skiv2l Gene Detail
Summary
  • Symbol
    Skiv2l
  • Name
    superkiller viralicidic activity 2-like (S. cerevisiae)
  • Synonyms
    4930534J06Rik, Ski2w
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099835
    NCBI Gene: 108077
  • Gene Overview
    MyGene.info: SKIV2L
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34839226-34850204 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099835
protein coding gene Chr17:34839226-34850210 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023591
protein coding gene Chr17:34951045-34962027 (-)
A/J MGP_AJ_G0023553
protein coding gene Chr17:33809484-33820395 (-)
AKR/J MGP_AKRJ_G0023519
protein coding gene Chr17:34268285-34279266 (-)
BALB/cJ MGP_BALBcJ_G0023558
protein coding gene Chr17:33939796-33950707 (-)
C3H/HeJ MGP_C3HHeJ_G0023318
protein coding gene Chr17:34667656-34678637 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023998
protein coding gene Chr17:36288355-36299337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021477
protein coding gene Chr17:31573996-31584873 (-)
CAST/EiJ MGP_CASTEiJ_G0022816
protein coding gene Chr17:34663395-34674383 (-)
CBA/J MGP_CBAJ_G0023296
protein coding gene Chr17:37799904-37810885 (-)
DBA/2J MGP_DBA2J_G0023424
protein coding gene Chr17:33123611-33134751 (-)
FVB/NJ MGP_FVBNJ_G0023391
protein coding gene Chr17:32953930-32964999 (-)
LP/J MGP_LPJ_G0023501
protein coding gene Chr17:35261901-35272883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023414
protein coding gene Chr17:36728724-36739637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024040
protein coding gene Chr17:34497395-34509170 (-)
PWK/PhJ MGP_PWKPhJ_G0022565
protein coding gene Chr17:31953303-31964327 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022382
protein coding gene Chr17:32499294-32510347 (-)
WSB/EiJ MGP_WSBEiJ_G0022878
protein coding gene Chr17:34606999-34617900 (-)



Homology
more
  • Human Ortholog
    SKIV2L, Ski2 like RNA helicase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SKIV2L, Ski2 like RNA helicase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L1, THES2
  • Links
    NCBI Gene ID: 6499
    neXtProt AC: NX_Q15477
    UniProt: Q15477

  • Chr Location
    6p21.33; chr6:31958804-31969852 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108077 NCBI Gene Model | MGI Sequence Detail 10979 C57BL/6J ±  kb
transcript NM_021337 RefSeq | MGI Sequence Detail 3972 C57BL/6  
polypeptide NP_067312 RefSeq | MGI Sequence Detail 1244 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR012961 ATP-dependent RNA helicase Ski2, C-terminal
    IPR016438 ATP-dependent RNA helicase Ski2-like
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR025696 rRNA-processing arch domain
Molecular
Reagents
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  • All nucleic 120
    Genomic 1
    cDNA 119

    Microarray probesets 2
Other
Accession IDs
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MGI:2147055, MGI:2148488, MGI:2442955
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory