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Tln1
Gene Detail
Symbol

Name
ID
Tln1
talin 1
MGI:1099832
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:43531519-43562691 bp, - strand
From VEGA annotation of GRCm38

  31173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tln1

Human
homologs
Human Homolog TLN1, talin 1
NCBI Gene ID 7094
neXtProt AC  NX_Q9Y490
Human Synonyms  ILWEQ, TLN
Human Chr (Location)  9p13; chr9:35697337-35732395 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(93) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for either one of two knock-out alleles display early developmental anomalies, reduced embryo size, and embryonic lethality due to impaired cell migration at the gastrulation stage.
 
Interactions
Tln1 interacts with 194 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell adhesion, cell-substrate junction assembly, ...
Component cell junction, cell projection, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (205)    Tissues (14)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 203
Western blot 2
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006961 (Evidence)
Ensembl Gene ModelENSMUSG00000028465 (Evidence)
Entrez Gene21894 (Evidence)
NIA Mouse Gene IndexU024990
PDB1XWX, 2B0H, 2JSW, 2KBB, 2KGX, 2KMA, 2KVP, 2L7A, 2L7N, 2LQG, 2QDQ, 2X0C, 3DYJ, 3IVF, 4F7G, 1SJ7, 1SJ8, 1T01, 1U89, 1Y19, 1ZW3, 2G35, 2KC1, 2KC2, 2L10, 3S90
Consensus CDS ProjectCCDS18101.1
International Mouse Knockout Project StatusTln1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006961 VEGA Gene Model | MGI Sequence Detail 31173 C57BL/6J ±  kb
transcript OTTMUST00000016126 VEGA | MGI Sequence Detail 8393 Not Applicable 
polypeptide OTTMUSP00000007396 VEGA | MGI Sequence Detail 2541 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR002558 I/LWEQ domain
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015710 Talin-1
InterPro IPR015224 Talin, central
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR015009 Vinculin-binding site-containing domain
Protein Ontology PR:000016381 talin-1
References
(Earliest) J:43417 Rees DJ, et al., Sequence and domain structure of talin. Nature. 1990 Oct 18;347(6294):685-9
(Latest) J:210743 Stefanini L, et al., A talin mutant that impairs talin-integrin binding in platelets decelerates alphaIIbbeta3 activation without pathological bleeding. Blood. 2014 Apr 24;123(17):2722-31
All references(85)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory