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Tln1 Gene Detail
Summary
  • Symbol
    Tln1
  • Name
    talin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099832
    NCBI Gene: 21894
  • Gene Overview
    MyGene.info: TLN1
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43531513-43562583 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099832
protein coding gene Chr4:43531513-43562691 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028212
protein coding gene Chr4:41652062-41684410 (-)
A/J MGP_AJ_G0028168
protein coding gene Chr4:40173304-40204388 (-)
AKR/J MGP_AKRJ_G0028120
protein coding gene Chr4:41085665-41116602 (-)
BALB/cJ MGP_BALBcJ_G0028188
protein coding gene Chr4:40262595-40294470 (-)
C3H/HeJ MGP_C3HHeJ_G0027910
protein coding gene Chr4:41714206-41746228 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028629
protein coding gene Chr4:43214008-43246664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025941
protein coding gene Chr4:37620714-37652698 (-)
CAST/EiJ MGP_CASTEiJ_G0027350
protein coding gene Chr4:41219447-41251843 (-)
CBA/J MGP_CBAJ_G0027876
protein coding gene Chr4:44523549-44565521 (-)
DBA/2J MGP_DBA2J_G0028025
protein coding gene Chr4:40082004-40114171 (-)
FVB/NJ MGP_FVBNJ_G0027992
protein coding gene Chr4:39304474-39336949 (-)
LP/J MGP_LPJ_G0028124
protein coding gene Chr4:41704860-41741205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028016
protein coding gene Chr4:47787617-47820281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028665
protein coding gene Chr4:41284967-41318588 (-)
PWK/PhJ MGP_PWKPhJ_G0027076
protein coding gene Chr4:40124725-40156782 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026902
protein coding gene Chr4:40849829-40880784 (-)
WSB/EiJ MGP_WSBEiJ_G0027430
protein coding gene Chr4:41186859-41219103 (-)



Homology
more
  • Human Ortholog
    TLN1, talin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TLN1, talin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ILWEQ, talin-1, TLN
  • Links
    NCBI Gene ID: 7094
    neXtProt AC: NX_Q9Y490
    UniProt: Q9Y490

  • Chr Location
    9p13.3; chr9:35697337-35732395 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for either one of two knock-out alleles display early developmental anomalies, reduced embryo size, and embryonic lethality due to impaired cell migration at the gastrulation stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21894 NCBI Gene Model | MGI Sequence Detail 31071 C57BL/6J ±  kb
    transcript NM_011602 RefSeq | MGI Sequence Detail 8560 C57BL/6  
    polypeptide P26039 UniProt | EBI | MGI Sequence Detail 2541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 15
      Gene Ontology 17
      Phenotypes 42
    • Earliest
      J:43417 Rees DJ, et al., Sequence and domain structure of talin. Nature. 1990 Oct 18;347(6294):685-9
    • Latest
      J:253408 Shiratori T, et al., IL-1beta Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1. J Immunol. 2018 Jan 1;200(1):218-228

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory