Hip1
Gene Detail

Symbol Name ID

Hip1 huntingtin interacting protein 1 MGI:1099804

Synonyms

2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1, MGC:27616

Feature Type

protein coding gene

Genetic Map

Chromosome 5

75.18 cM, cytoband F-G2
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr5:135406523-135545122 bp, - strand From Ensembl annotation of GRCm38   138600 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: huntingtin-interacting protein 1-related protein
Gene Tree: Hip1

Human homologs

Human Homolog		HIP1, huntingtin interacting protein 1
NCBI Gene ID		3092
neXtProt AC		NX_O00291
Human Synonyms		ILWEQ
Human Chr (Location)		7q11.23; chr7:75162619-75368283 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HIP1

Alleles and phenotypes

All alleles(32) : Targeted(8) Gene trapped(24)
 

Homozygous mutants may exhibit axial skeleton defects, hematopotietic abnormalities, and testicular degeneration with increased apoptosis of postmeiotic spermatids. One line showed microphthalmia and cataracts, whereas others did not.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	clathrin-coated vesicle, cytoplasm, ...
Function	actin binding, clathrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (19)    Tissues (14)    Images (4)
Theiler Stages: 10, 13, 18, 21, 23, 25, 28

Assay Type	Results
RNA in situ	7
Northern blot	4
Western blot	4
RT-PCR	4

cDNA source data(123)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(139) Genomic(10) cDNA(126) Primer pair(2) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000039959 (Evidence)
Entrez Gene	215114 (Evidence)
UniGene	280805
DFCI	TC1584705, TC1595659, TC1598225, TC1599229, TC1599534, TC1614306
DoTS	DT.101204655, DT.101258801, DT.40150275, DT.485863, DT.91383136, DT.91406165
NIA Mouse Gene Index	U026819
Consensus CDS Project	CCDS51663.1
International Mouse Knockout Project Status	Hip1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000039959	Ensembl Gene Model | MGI Sequence Detail	138600	C57BL/6J
transcript	ENSMUST00000060311	Ensembl | MGI Sequence Detail	7850	Not Applicable
polypeptide	ENSMUSP00000059033	Ensembl | MGI Sequence Detail	1029	Not Applicable

All sequences(44) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(585 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011417	ANTH
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR008942	ENTH/VHS
InterPro	IPR013809	Epsin-like, N-terminal
InterPro	IPR002558	I/LWEQ
Protein Ontology	PR:000008564	huntingtin-interacting protein 1

References

(Earliest) J:43669 Himmelbauer H, et al., IRS-PCR-based mapping of the Huntingtin interacting protein (HIP1) on mouse Chromosome 5. Mamm Genome. 1998 Jan;9(1):26-31
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(62)

Other accession IDs

MGI:1924028, MGI:1924349, MGI:2443720