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Hip1
Gene Detail
Symbol

Name
ID
Hip1
huntingtin interacting protein 1
MGI:1099804
Synonyms
2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1, MGC:27616
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.18 cM, cytoband F-G2
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr5:135406523-135545122 bp, - strand
From Ensembl annotation of GRCm38

  138600 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HIP1
Protein SuperFamily: huntingtin-interacting protein 1-related protein
Gene Tree: Hip1

Human
homologs
HIP1, huntingtin interacting protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3092
neXtProt AC: NX_O00291

Human Synonyms: HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma

Human Chr (Location): 7q11.23; chr7:75533298-75738972 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HIP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(24) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants may exhibit axial skeleton defects, hematopotietic abnormalities, and testicular degeneration with increased apoptosis of postmeiotic spermatids. One line showed microphthalmia and cataracts, whereas others did not.
 
Interactions
Hip1 interacts with 451 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component clathrin-coated vesicle, cytoplasm, ...
Function actin binding, clathrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (14)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
Northern blot 4
Western blot 4
RT-PCR 2
cDNA source data(123)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hip1 ; ZFIN hip1    NEW 
Molecular
reagents
All nucleic(139) Genomic(10) cDNA(126) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000039959 (Evidence)
Entrez Gene 215114 (Evidence)
UniGene 280805
DFCI TC1595659, TC1598225, TC1584705, TC1614306, TC1599534, TC1599229
DoTS DT.101258801, DT.101204655, DT.40150275, DT.91383136, DT.485863, DT.91406165
NIA Mouse Gene Index U026819
Consensus CDS Project CCDS51663.1
International Mouse Phenotyping Consortium Status Hip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039959 Ensembl Gene Model | MGI Sequence Detail 138600 C57BL/6J ±  kb
transcript ENSMUST00000060311 Ensembl | MGI Sequence Detail 7850 Not Applicable 
polypeptide ENSMUSP00000059033 Ensembl | MGI Sequence Detail 1029 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(9) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(642 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011417 AP180 N-terminal homology (ANTH) domain
InterPro IPR008942 ENTH/VHS
InterPro IPR013809 Epsin-like, N-terminal
InterPro IPR002558 I/LWEQ domain
Protein Ontology PR:000008564 huntingtin-interacting protein 1
References
(Earliest) J:43669 Himmelbauer H, et al., IRS-PCR-based mapping of the Huntingtin interacting protein (HIP1) on mouse Chromosome 5. Mamm Genome. 1998 Jan;9(1):26-31
(Latest) J:216270 Philips ST, et al., Toward a therapeutic reduction of imatinib refractory myeloproliferative neoplasm-initiating cells. Oncogene. 2014 Nov 13;33(46):5379-90
All references(61)
Other
accession IDs
MGI:1924028, MGI:1924349, MGI:2443720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory