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Npdc1 Gene Detail
Summary
  • Symbol
    Npdc1
  • Name
    neural proliferation, differentiation and control 1
  • Synonyms
    NPDC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099802
    NCBI Gene: 18146
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25293067-25299504 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099802
 protein coding gene Chr2:25289363-25299506 (+)
129S1/SvImJ ENSMUSG00200048844
 protein coding gene Chr2:22277255-22283676 (+)
A/J ENSMUSG00195039889
 protein coding gene Chr2:22367229-22373712 (+)
AKR/J ENSMUSG00220050658
 protein coding gene Chr2:22485062-22491545 (+)
BALB/cJ ENSMUSG00180053195
 protein coding gene Chr2:22378875-22385299 (+)
C3H/HeJ ENSMUSG00175051223
 protein coding gene Chr2:22343025-22349449 (+)
C57BL/6NJ ENSMUSG00215045366
 protein coding gene Chr2:22401769-22408190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023272
 protein coding gene Chr2:21293934-21303980 (+)
CAST/EiJ ENSTCUG00005051476
 protein coding gene Chr2:22127033-22133482 (+)
CBA/J ENSMUSG00210016431
 protein coding gene Chr2:22382035-22388458 (+)
DBA/2J ENSMUSG00185050690
 protein coding gene Chr2:22281439-22287922 (+)
FVB/NJ ENSMUSG00205036650
 protein coding gene Chr2:22135868-22142292 (+)
JF1/MsJ ENSUMUG00000055834
 protein coding gene Chr2:22196738-22203211 (+)
LP/J ENSMUSG00230042202
 protein coding gene Chr2:24213238-24219661 (+)
NOD/ShiLtJ ENSMUSG00190035754
 protein coding gene Chr2:22372313-22378796 (+)
NZO/HlLtJ ENSMUSG00225010553
 protein coding gene Chr2:31963655-31970064 (+)
PWK/PhJ ENSLUMG00010043769
 protein coding gene Chr2:22294120-22300558 (+)
SPRET/EiJ ENSMSPG00010031847
 protein coding gene Chr2:22981190-22987596 (+)
WSB/EiJ ENSIUOG00005050642
 protein coding gene Chr2:22239577-22246063 (+)



Homology
more
  • Human Ortholog
    NPDC1, neural proliferation, differentiation and control 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPDC1, neural proliferation, differentiation and control 1
  • Synonyms
    CAB, CAB-, CAB-1, CAB1, NPDC-1
  • Links
    NCBI Gene ID: 56654
    UniProt: Q9NQX5

  • Chr Location
    9q34.3; chr9:137039459-137046695 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Homozygous null mice display no obvious abnormalities in viability, fertility, behavior, or brain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    31
  • cDNA Data
    150
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18146 NCBI Gene Model | MGI Sequence Detail 6438 C57BL/6J ±  kb
transcript NM_001420469 RefSeq | MGI Sequence Detail 1535 C57BL/6  
polypeptide Q64322 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011359 neural proliferation differentiation and control protein 1
    (term hierarchy)
  • InterPro Domains
    IPR009635 Neural proliferation differentiation control-1
  • GlyGen
    Q64322 3 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 152
    cDNA 151
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138881
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:23322 Galiana E, et al., Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1560-4
  • Latest
    J:378433 Perez-Canamas A, et al., mGluR4-NPDC1 complex mediates alpha-synuclein fibril-induced neurodegeneration. Nat Commun. 2025 Dec 25;17(1):994
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory