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Npdc1 Gene Detail
Summary
  • Symbol
    Npdc1
  • Name
    neural proliferation, differentiation and control 1
  • Synonyms
    NPDC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099802
    NCBI Gene: 18146
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25293062-25299506 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099802
 protein coding gene Chr2:25289363-25299506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025444
 protein coding gene Chr2:23283676-23295328 (+)
A/J MGP_AJ_G0025421
 protein coding gene Chr2:22382853-22393135 (+)
AKR/J MGP_AKRJ_G0025391
 protein coding gene Chr2:23129836-23140052 (+)
BALB/cJ MGP_BALBcJ_G0025417
 protein coding gene Chr2:22496015-22506563 (+)
C3H/HeJ MGP_C3HHeJ_G0025178
 protein coding gene Chr2:23067432-23079495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025861
 protein coding gene Chr2:24032919-24044228 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023272
 protein coding gene Chr2:21293934-21303980 (+)
CAST/EiJ MGP_CASTEiJ_G0024641
 protein coding gene Chr2:22945273-22956582 (+)
CBA/J MGP_CBAJ_G0025156
 protein coding gene Chr2:24861093-24873561 (+)
DBA/2J MGP_DBA2J_G0025289
 protein coding gene Chr2:22222263-22232403 (+)
FVB/NJ MGP_FVBNJ_G0025251
 protein coding gene Chr2:21964935-21976007 (+)
LP/J MGP_LPJ_G0025375
 protein coding gene Chr2:23227222-23239378 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025282
 protein coding gene Chr2:25053321-25065396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025920
 protein coding gene Chr2:23083313-23095873 (+)
PWK/PhJ MGP_PWKPhJ_G0024389
 protein coding gene Chr2:22043283-22054937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024189
 protein coding gene Chr2:23226808-23237957 (+)
WSB/EiJ MGP_WSBEiJ_G0024710
 protein coding gene Chr2:23157343-23169840 (+)



Homology
more
  • Human Ortholog
    NPDC1, neural proliferation, differentiation and control 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPDC1, neural proliferation, differentiation and control 1
  • Synonyms
    CAB, CAB-, CAB1, CAB-1, NPDC-1
  • Links
    NCBI Gene ID: 56654
    neXtProt AC: NX_Q9NQX5
    UniProt: Q9NQX5

  • Chr Location
    9q34.3; chr9:137039463-137046179 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Homozygous null mice display no obvious abnormalities in viability, fertility, behavior, or brain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    31
  • cDNA Data
    150
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18146 NCBI Gene Model | MGI Sequence Detail 6445 C57BL/6J ±  kb
transcript NM_001420469 RefSeq | MGI Sequence Detail 1535 C57BL/6  
polypeptide Q64322 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011359 neural proliferation differentiation and control protein 1
    (term hierarchy)
  • InterPro Domains
    IPR009635 Neural proliferation differentiation control-1
Molecular
Reagents
less
  • All nucleic 152
    cDNA 151
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138881
References
more
  • Summaries
    All 28
    Developmental Gene Expression 6
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:23322 Galiana E, et al., Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1560-4
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory