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Ptpn4
Gene Detail
 Symbol
Name
ID
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
MGI:1099792
Synonyms hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase
Feature Type protein coding gene
Genetic Map
Chromosome 1
52.39 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:119658044-119837613 bp, - strand
From VEGA annotation of GRCm38

  179570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 3/4 types
Gene Tree: Ptpn4

Human
homologs
Human Homolog PTPN4, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NCBI Gene ID 5775
neXtProt AC  NX_P29074
Human Synonyms  MEG, PTPMEG, PTPMEG1
Human Chr (Location)  2q14.2; chr2:119759631-119984899 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.
 
Interactions
Ptpn4 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dephosphorylation, peptidyl-tyrosine dephosphorylation, ...
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function cytoskeletal protein binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (38)    Images (26)
Theiler Stages: 10, 16, 21, 23, 25, 28
Assay TypeResults
RNA in situ 60
RT-PCR 40
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035374 (Evidence)
Ensembl Gene ModelENSMUSG00000026384 (Evidence)
Entrez Gene19258 (Evidence)
UniGene458796
DFCITC1588609, TC1592417
DoTSDT.101307312, DT.110927698, DT.110927717, DT.40163884
NIA Mouse Gene IndexU021699
EC3.1.3.48
Consensus CDS ProjectCCDS15227.1
International Mouse Knockout Project StatusPtpn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035374 VEGA Gene Model | MGI Sequence Detail 179570 C57BL/6J ±  kb
transcript OTTMUST00000090386 VEGA | MGI Sequence Detail 3596 Not Applicable 
polypeptide OTTMUSP00000049572 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(10) UniProt(12)
Polymorphisms SNPs within 2kb(339 from dbSNP Build 137)    SNPs within 2kb including multiple locations(341)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013459 tyrosine-protein phosphatase non-receptor type 4
References (Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:196081 Kohda K, et al., The delta2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E948-57
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory