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Ptpn4 Gene Detail
Summary
  • Symbol
    Ptpn4
  • Name
    protein tyrosine phosphatase, non-receptor type 4
  • Synonyms
    hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099792
    NCBI Gene: 19258
  • Gene Overview
    MyGene.info: PTPN4
Location & Maps
more
  • Sequence Map
    Chr1:119652467-119837613 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      185147 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.39 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTPN4, protein tyrosine phosphatase, non-receptor type 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPN4, protein tyrosine phosphatase, non-receptor type 4
    Orthology source: HomoloGene
  • Synonyms
    MEG, PTPMEG, PTPMEG1
  • Links
    NCBI Gene ID: 5775
    neXtProt AC: NX_P29074

  • Chr Location
    2q14.2; chr2:119759631-119984899 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Ptpn4
  • Incidental Mutations
Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035374 VEGA Gene Model | MGI Sequence Detail 185147 C57BL/6J ±  kb
transcript OTTMUST00000090386 VEGA | MGI Sequence Detail 10874 Not Applicable  
polypeptide OTTMUSP00000049572 VEGA | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    336 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
  • Latest
    J:196081 Kohda K, et al., The delta2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E948-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory