About   Help   FAQ
Ptpn4
Gene Detail
Symbol

Name
ID
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
MGI:1099792
Synonyms
hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.39 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:119652467-119837613 bp, - strand
From VEGA annotation of GRCm38

  185147 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPN4
Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 3/4 types
Gene Tree: Ptpn4

Human
homologs
PTPN4, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5775
neXtProt AC: NX_P29074

Human Synonyms: MEG, PTPMEG, PTPMEG1

Human Chr (Location): 2q14.2; chr2:119759631-119984899 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.
 
Interactions
Ptpn4 interacts with 378 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dephosphorylation, peptidyl-tyrosine dephosphorylation, ...
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function cytoskeletal protein binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (38)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
RT-PCR 40
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptpn4    NEW 
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035374 (Evidence)
Ensembl Gene Model ENSMUSG00000026384 (Evidence)
Entrez Gene 19258 (Evidence)
UniGene 458796
DFCI TC1588609, TC1592417
DoTS DT.101307312, DT.110927698, DT.110927717, DT.40163884
NIA Mouse Gene Index U021699
EC 3.1.3.48
Consensus CDS Project CCDS15227.1
International Mouse Phenotyping Consortium Status Ptpn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035374 VEGA Gene Model | MGI Sequence Detail 185147 C57BL/6J ±  kb
transcript OTTMUST00000090386 VEGA | MGI Sequence Detail 10874 Not Applicable 
polypeptide OTTMUSP00000049572 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(12) UniProt(12)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)    SNPs within 2kb including multiple locations(348)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR000798 Ezrin/radixin/moesin-like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
InterPro IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
InterPro IPR000242 PTP type protein phosphatase
InterPro IPR000387 Tyrosine specific protein phosphatases domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000013459 tyrosine-protein phosphatase non-receptor type 4
References
(Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:196081 Kohda K, et al., The delta2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E948-57
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory