Ucp3
Gene Detail

Symbol Name ID

Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) MGI:1099787

Synonyms

Slc25a9, UCP-3

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr7:100472990-100486432 bp, + strand From VEGA annotation of GRCm38   13443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ucp3

Human homologs

Human Homolog		UCP3, uncoupling protein 3 (mitochondrial, proton carrier)
NCBI Gene ID		7352
neXtProt AC		NX_P55916
Human Synonyms		SLC25A9
Human Chr (Location)		11q13.4; chr11:73711326-73720282 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UCP3

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null mutants exhibit a lack of superoxide-induced uncoupling in skeletal muscle mitochondria, accompanied by increased reactive oxygen species formation.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	fatty acid metabolic process, mitochondrial transport, ...
Component	integral to membrane, membrane, ...
Function	oxidative phosphorylation uncoupler activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (15)    Tissues (12)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	1
Northern blot	8
RT-PCR	6

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022800 (Evidence)
Ensembl Gene Model	ENSMUSG00000032942 (Evidence)
Entrez Gene	22229 (Evidence)
UniGene	6254
DFCI	TC1585481
DoTS	DT.101722706, DT.110980738, DT.522330, DT.87028299
NIA Mouse Gene Index	U008453
Consensus CDS Project	CCDS21497.1
International Mouse Knockout Project Status	Ucp3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022800	VEGA Gene Model | MGI Sequence Detail	13443	C57BL/6J
transcript	OTTMUST00000054783	VEGA | MGI Sequence Detail	2448	Not Applicable
polypeptide	OTTMUSP00000026173	VEGA | MGI Sequence Detail	308	Not Applicable

All sequences(38) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(109 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002030	Mitochondrial brown fat uncoupling protein
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000017037	mitochondrial uncoupling protein 3

References

(Earliest) J:43539 Gong DW, et al., Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 1997 Sep 26;272(39):24129-32
(Latest) J:182286 Charalambous M, et al., Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21
All references(75)

Other accession IDs

MGI:2142016