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Ucp3
Gene Detail
Symbol

Name
ID
Ucp3
uncoupling protein 3 (mitochondrial, proton carrier)
MGI:1099787
Synonyms
Slc25a9, UCP-3
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:100472990-100486432 bp, + strand
From VEGA annotation of GRCm38

  13443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UCP3
Gene Tree: Ucp3

Human
homologs
UCP3, uncoupling protein 3 (mitochondrial, proton carrier)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7352
neXtProt AC: NX_P55916

Human Synonyms: SLC25A9

Human Chr (Location): 11q13.4; chr11:74000281-74009237 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UCP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit a lack of superoxide-induced uncoupling in skeletal muscle mitochondria, accompanied by increased reactive oxygen species formation.
 
Interactions
Ucp3 interacts with 198 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process fatty acid metabolic process, mitochondrial transport, ...
Component integral component of membrane, membrane, ...
Function oxidative phosphorylation uncoupler activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (15)    Tissues (12)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
Northern blot 8
RT-PCR 6
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495495 ; ZFIN ucp3    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022800 (Evidence)
Ensembl Gene Model ENSMUSG00000032942 (Evidence)
Entrez Gene 22229 (Evidence)
UniGene 6254
DFCI TC1585481
DoTS DT.101722706, DT.110980738, DT.522330, DT.87028299
NIA Mouse Gene Index U008453
Consensus CDS Project CCDS21497.1
International Mouse Phenotyping Consortium Status Ucp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022800 VEGA Gene Model | MGI Sequence Detail 13443 C57BL/6J ±  kb
transcript OTTMUST00000054783 VEGA | MGI Sequence Detail 2448 Not Applicable 
polypeptide OTTMUSP00000026173 VEGA | MGI Sequence Detail 308 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000017037 mitochondrial uncoupling protein 3
References
(Earliest) J:43539 Gong DW, et al., Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 1997 Sep 26;272(39):24129-32
(Latest) J:222220 Iso T, et al., Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2549-57
All references(78)
Other
accession IDs
MGI:2142016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory