About   Help   FAQ
Ucp3 Gene Detail
Summary
  • Symbol
    Ucp3
  • Name
    uncoupling protein 3 (mitochondrial, proton carrier)
  • Synonyms
    Slc25a9, UCP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099787
    NCBI Gene: 22229
  • Gene Overview
    MyGene.info: UCP3
Location & Maps
more
  • Sequence Map
    Chr7:100472990-100486432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    UCP3, uncoupling protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UCP3, uncoupling protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SLC25A9
  • Links
    NCBI Gene ID: 7352
    neXtProt AC: NX_P55916

  • Chr Location
    11q13.4; chr11:74000281-74009237 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2517
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: UCP3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human UCP3 associations

Human Disease Mouse Models
       Obesity   OMIM: 601665
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Ucp3
  • Incidental Mutations
Homozygous null mutants exhibit a lack of superoxide-induced uncoupling in skeletal muscle mitochondria, accompanied by increased reactive oxygen species formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022800 VEGA Gene Model | MGI Sequence Detail 13443 C57BL/6J ±  kb
transcript OTTMUST00000054785 VEGA | MGI Sequence Detail 1260 Not Applicable  
polypeptide OTTMUSP00000026174 VEGA | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    158 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017037 mitochondrial uncoupling protein 3
  • InterPro Domains
    IPR002030 Mitochondrial brown fat uncoupling protein
    IPR023395 Mitochondrial carrier domain
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
less
  • All nucleic 26
    Genomic 2
    cDNA 21
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142016
References
more
  • Summaries
    All 77
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 41
  • Earliest
    J:43539 Gong DW, et al., Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 1997 Sep 26;272(39):24129-32
  • Latest
    J:224170 Zolfaghari PS, et al., Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E713-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory