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Dhx15 Gene Detail
Summary
  • Symbol
    Dhx15
  • Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 15
  • Synonyms
    DBP1, Ddx15, HRH2, mDEAH9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099786
    NCBI Gene: 13204
  • Gene Overview
    MyGene.info: DHX15
Location & Maps
more
  • Sequence Map
    Chr5:52150203-52190514 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40312 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 27.51 cM, cytoband C1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DHX15, DEAH-box helicase 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHX15, DEAH-box helicase 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p
  • Links
    NCBI Gene ID: 1665
    neXtProt AC: NX_O43143

  • Chr Location
    4p15.3; chr4:24527464-24584603 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1040
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DHX15
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotype references
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    2
  • Gene trapped
    32
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Dhx15
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054564 VEGA Gene Model | MGI Sequence Detail 40312 C57BL/6J ±  kb
transcript OTTMUST00000135253 VEGA | MGI Sequence Detail 3010 Not Applicable  
polypeptide OTTMUSP00000071601 VEGA | MGI Sequence Detail 795 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    185 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000029412 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
  • EC
  • InterPro Domains
    IPR011545 DEAD/DEAH box helicase domain
    IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    IPR011709 Domain of unknown function DUF1605
    IPR007502 Helicase-associated domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 289
    cDNA 289

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 24
  • Earliest
    J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
  • Latest
    J:223990 Parsons MJ, et al., The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell. 2015 Jul 30;162(3):607-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory