She Gene Detail

Summary

• Symbol
  She
• Name
  src homology 2 domain-containing transforming protein E

• Feature Type
  protein coding gene
• IDs
  MGI:1099462
  NCBI Gene: 214547
• Alliance
  genome feature page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr3:89738677-89766141 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 39.19 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  892 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099462	protein coding gene	Chr3:89738667-89766149 (+)
129S1/SvImJ	ENSMUSG00200039259	protein coding gene	Chr3:86593994-86621465 (+)
A/J	ENSMUSG00195052281	protein coding gene	Chr3:86609133-86636602 (+)
AKR/J	ENSMUSG00220049742	protein coding gene	Chr3:86563647-86591116 (+)
BALB/cJ	ENSMUSG00180043188	protein coding gene	Chr3:86700874-86728326 (+)
C3H/HeJ	ENSMUSG00175046612	protein coding gene	Chr3:86541704-86569173 (+)
C57BL/6NJ	ENSMUSG00215045869	protein coding gene	Chr3:86981741-87009208 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025218	protein coding gene	Chr3:82576121-82605525 (+)
CAST/EiJ	ENSTCUG00005043202	protein coding gene	Chr3:86061416-86089528 (+)
CBA/J	ENSMUSG00210038934	protein coding gene	Chr3:86679350-86706817 (+)
DBA/2J	ENSMUSG00185049540	protein coding gene	Chr3:86789296-86816747 (+)
FVB/NJ	ENSMUSG00205045811	protein coding gene	Chr3:85603316-85630782 (+)
JF1/MsJ	ENSUMUG00000044472	protein coding gene	Chr3:86394327-86422541 (+)
LP/J	ENSMUSG00230028793	protein coding gene	Chr3:88815250-88842721 (+)
NOD/ShiLtJ	ENSMUSG00190026702	protein coding gene	Chr3:87067883-87095342 (+)
NZO/HlLtJ	ENSMUSG00225012255	protein coding gene	Chr3:91573393-91600841 (+)
PWK/PhJ	ENSLUMG00010039895	protein coding gene	Chr3:86434576-86462965 (+)
SPRET/EiJ	ENSMSPG00010049338	protein coding gene	Chr3:87307368-87332349 (+)
WSB/EiJ	ENSIUOG00005043979	protein coding gene	Chr3:87094645-87122104 (+)

Homology

• Human Ortholog
  SHE, Src homology 2 domain containing E

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SHE, Src homology 2 domain containing E
  
• Links
  HGNC:27004

  NCBI Gene ID: 126669

  UniProt: Q5VZ18

  
  
• Chr Location
  1q21.3; chr1:154469637-154502472 (-)  GRCh38

---

• MGI Vertebrate Homology
  She stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SHE
• Gene Tree
  She
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotype references
  

• All Mutations and Alleles
  13
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  6
• Radiation induced
  1
• Targeted
  4
• Genomic Mutations
  2 involving She
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  19 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  624
• Tissues
  4
• cDNA Data
  13
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase she
  ZFIN she

Sequences &
Gene Models

• All Sequences
  37
• RefSeq
  4
• UniProt
  2
• CCDS
  CCDS17518.1

• Ensembl
  ENSMUSG00000046280 (Evidence)
• NCBI Gene
  214547

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046280	Ensembl Gene Model | MGI Sequence Detail	27465	C57BL/6J
transcript	ENSMUST00000050401	Ensembl | MGI Sequence Detail	5733	Not Applicable
polypeptide	ENSMUSP00000059658	Ensembl | MGI Sequence Detail	492	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000030650 SH2 domain-containing adapter protein E
  (term hierarchy)
• InterPro Domains
  IPR000980 SH2 domain
  IPR051846 SH2 domain-containing adapter proteins
  IPR036860 SH2 domain superfamily
  IPR035042 SHE, SH2 domain
• GlyGen
  Q8BSD5 1 site

Molecular
Reagents

• All nucleic 13

  cDNA 13

  
  

  Microarray probesets 4

References

• Summaries
  All 33

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 1

  Phenotypes 11
• Earliest
  J:43082 Oda T, et al., Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene. 1997 Sep;15(11):1255-62
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for She:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30140	Chr3:89738659-89738691 (+)	-2 bp
Tssr30141	Chr3:89738702-89738713 (+)	31 bp