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Shd Gene Detail
Summary
  • Symbol
    Shd
  • Name
    src homology 2 domain-containing transforming protein D
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099461
    NCBI Gene: 20420
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56277467-56283625 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099461
 protein coding gene Chr17:56276828-56283625 (+)
129S1/SvImJ ENSMUSG00200016395
 protein coding gene Chr17:51552514-51558667 (+)
A/J ENSMUSG00195006766
 protein coding gene Chr17:52939969-52946122 (+)
AKR/J ENSMUSG00220012575
 protein coding gene Chr17:51989407-51995561 (+)
BALB/cJ ENSMUSG00180005993
 protein coding gene Chr17:52697601-52703753 (+)
C3H/HeJ ENSMUSG00175006783
 protein coding gene Chr17:52013675-52019829 (+)
C57BL/6NJ ENSMUSG00215007241
 protein coding gene Chr17:51627792-51633945 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021756
 protein coding gene Chr17:52560205-52566429 (+)
CAST/EiJ ENSTCUG00005018105
 protein coding gene Chr17:52748692-52755022 (+)
CBA/J ENSMUSG00210026180
 protein coding gene Chr17:51780734-51786887 (+)
DBA/2J ENSMUSG00185009004
 protein coding gene Chr17:54650595-54656749 (+)
FVB/NJ ENSMUSG00205006733
 protein coding gene Chr17:52328208-52334361 (+)
JF1/MsJ ENSUMUG00000021412
 protein coding gene Chr17:54328517-54334904 (+)
LP/J ENSMUSG00230024365
 protein coding gene Chr17:55629963-55636116 (+)
NOD/ShiLtJ ENSMUSG00190009803
 protein coding gene Chr17:51783303-51789456 (+)
NZO/HlLtJ ENSMUSG00225041753
 protein coding gene Chr17:57913803-57919955 (+)
PWK/PhJ ENSLUMG00010009024
 protein coding gene Chr17:51589455-51595852 (+)
SPRET/EiJ ENSMSPG00010005658
 protein coding gene Chr17:51906685-51912854 (+)
WSB/EiJ ENSIUOG00005023622
 protein coding gene Chr17:52690095-52696242 (+)



Homology
more
  • Human Ortholog
    SHD, Src homology 2 domain containing transforming protein D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHD, Src homology 2 domain containing transforming protein D
  • Links
    NCBI Gene ID: 56961
    UniProt: Q96IW2

  • Chr Location
    19p13.3; chr19:4279030-4290725 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039154 Ensembl Gene Model | MGI Sequence Detail 6159 C57BL/6J ±  kb
transcript ENSMUST00000223629 Ensembl | MGI Sequence Detail 1430 Not Applicable  
polypeptide ENSMUSP00000153605 Ensembl | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 17

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146835
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:43082 Oda T, et al., Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene. 1997 Sep;15(11):1255-62
  • Latest
    J:317822 Chern T, et al., Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory