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Rbm3 Gene Detail
Summary
  • Symbol
    Rbm3
  • Name
    RNA binding motif (RNP1, RRM) protein 3
  • Synonyms
    2600016C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099460
    NCBI Gene: 19652
  • Gene Overview
    MyGene.info: RBM3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8138975-8145880 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099460
protein coding gene ChrX:8138975-8145880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035541
protein coding gene ChrX:2785160-2792393 (-)
A/J MGP_AJ_G0035518
protein coding gene ChrX:2761105-2767541 (-)
AKR/J MGP_AKRJ_G0035451
protein coding gene ChrX:2874791-2884023 (-)
BALB/cJ MGP_BALBcJ_G0035515
protein coding gene ChrX:2758358-2765771 (-)
C3H/HeJ MGP_C3HHeJ_G0035223
protein coding gene ChrX:2841700-2849457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036039
protein coding gene ChrX:2880819-2887507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032914
protein coding gene ChrX:2286070-2292645 (-)
CAST/EiJ MGP_CASTEiJ_G0034524
protein coding gene ChrX:2729570-2736690 (-)
CBA/J MGP_CBAJ_G0035193
protein coding gene ChrX:3032792-3039291 (-)
DBA/2J MGP_DBA2J_G0035350
protein coding gene ChrX:2746824-2753511 (-)
FVB/NJ MGP_FVBNJ_G0035297
protein coding gene ChrX:2712502-2719746 (-)
LP/J MGP_LPJ_G0035427
protein coding gene ChrX:2807407-2813613 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035337
protein coding gene ChrX:2980567-2987789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036057
protein coding gene ChrX:2766790-2774368 (-)
PWK/PhJ MGP_PWKPhJ_G0034224
protein coding gene ChrX:2688777-2695756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034063
protein coding gene ChrX:2745283-2752255 (-)
WSB/EiJ MGP_WSBEiJ_G0034647
protein coding gene ChrX:2770556-2778435 (-)



Homology
more
  • Human Ortholog
    RBM3, RNA binding motif protein 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RBM3, RNA binding motif protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IS1-RNPL, RNPL
  • Links
    NCBI Gene ID: 5935
    neXtProt AC: NX_P98179
    UniProt: P98179

  • Chr Location
    Xp11.23; chrX:48574353-48581165 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19652 NCBI Gene Model | MGI Sequence Detail 6906 C57BL/6J ±  kb
    transcript NM_016809 RefSeq | MGI Sequence Detail 2978 C57BL/6  
    polypeptide O89086 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034278 RBM3/CIRBP, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919317
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:43904 Derry JM, et al., RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. Hum Mol Genet. 1995 Dec;4(12):2307-11
    • Latest
      J:239631 Borowiec AS, et al., Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016 Sep;30(9):3155-70

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory