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Ccl25 Gene Detail
Summary
  • Symbol
    Ccl25
  • Name
    chemokine (C-C motif) ligand 25
  • Synonyms
    CKb15, Scya25, TECK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099448
    NCBI Gene: 20300
Location & Maps
more
  • Genetic Map
    Chromosome 8, 2.01 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Ckb15, SCYA25, TECK
  • Links
    NCBI Gene ID: 6370
    neXtProt AC: NX_O15444

  • Chr Location
    19p13.2; chr19:8052340-8062663 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Gene trapped
    20
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022436 VEGA Gene Model | MGI Sequence Detail 34811 C57BL/6J ±  kb
transcript OTTMUST00000053637 VEGA | MGI Sequence Detail 867 Not Applicable  
polypeptide OTTMUSP00000025512 VEGA | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    217 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:2142637
References
more
  • Summaries
    All 54
    Developmental Gene Expression 14
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:42501 Vicari AP, et al., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity. 1997 Aug;7(2):291-301
  • Latest
    J:214377 Zhang SL, et al., Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice. Blood. 2014 Jul 10;124(2):296-304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory