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Nnmt Gene Detail
Summary
  • Symbol
    Nnmt
  • Name
    nicotinamide N-methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099443
    NCBI Gene: 18113
  • Gene Overview
    MyGene.info: NNMT
Location & Maps
more
  • Sequence Map
    Chr9:48591877-48605153 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13277 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.45 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NNMT, nicotinamide N-methyltransferase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NNMT, nicotinamide N-methyltransferase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4837
    neXtProt AC: NX_P40261

  • Chr Location
    11q23.1; chr11:114295813-114312516 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027445 VEGA Gene Model | MGI Sequence Detail 13277 C57BL/6J ±  kb
transcript OTTMUST00000067908 VEGA | MGI Sequence Detail 1043 Not Applicable  
polypeptide OTTMUSP00000034246 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    864 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011297 nicotinamide N-methyltransferase
  • PDB
  • EC
  • InterPro Domains
    IPR000940 Methyltransferase, NNMT/PNMT/TEMT
    IPR025820 Methyltransferase NNMT/PNMT/TEMT, conserved site
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
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  • All nucleic 14
    Genomic 2
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:32997 Scheller T, et al., Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains. Pharmacogenetics. 1996 Feb;6(1):43-53
  • Latest
    J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory