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Suv39h1 Gene Detail
Summary
  • Symbol
    Suv39h1
  • Name
    suppressor of variegation 3-9 1
  • Synonyms
    DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099440
    NCBI Gene: 20937
  • Gene Overview
    MyGene.info: SUV39H1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8061171-8074760 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.64 cM, cytoband A1-A2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099440
protein coding gene ChrX:8061171-8074760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035538
protein coding gene ChrX:2701019-2714609 (-)
A/J MGP_AJ_G0035515
protein coding gene ChrX:2681571-2696885 (-)
AKR/J MGP_AKRJ_G0035448
protein coding gene ChrX:2783506-2797106 (-)
BALB/cJ MGP_BALBcJ_G0035512
protein coding gene ChrX:2677749-2691274 (-)
C3H/HeJ MGP_C3HHeJ_G0035220
protein coding gene ChrX:2751881-2765469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036036
protein coding gene ChrX:2788141-2801723 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032911
protein coding gene ChrX:2207926-2221219 (-)
CAST/EiJ MGP_CASTEiJ_G0034521
protein coding gene ChrX:2644337-2657947 (-)
CBA/J MGP_CBAJ_G0035190
protein coding gene ChrX:2941683-2955268 (-)
DBA/2J MGP_DBA2J_G0035347
protein coding gene ChrX:2669471-2683057 (-)
FVB/NJ MGP_FVBNJ_G0035294
protein coding gene ChrX:2633786-2647321 (-)
LP/J MGP_LPJ_G0035424
protein coding gene ChrX:2717630-2732675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035334
protein coding gene ChrX:2895616-2909205 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036054
protein coding gene ChrX:2685466-2699066 (-)
PWK/PhJ MGP_PWKPhJ_G0034221
protein coding gene ChrX:2604870-2618457 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034060
protein coding gene ChrX:2663838-2677395 (-)
WSB/EiJ MGP_WSBEiJ_G0034644
protein coding gene ChrX:2690282-2703870 (-)



Homology
more
  • Human Ortholog
    SUV39H1, suppressor of variegation 3-9 homolog 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SUV39H1, suppressor of variegation 3-9 homolog 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H3-K9-HMTase 1, KMT1A, MG44, SUV39H
  • Links
    NCBI Gene ID: 6839
    neXtProt AC: NX_O43463
    UniProt: O43463

  • Chr Location
    Xp11.23; chrX:48695554-48709016 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20937 NCBI Gene Model | MGI Sequence Detail 13590 C57BL/6J ±  kb
transcript NM_001358237 RefSeq | MGI Sequence Detail 3154 C57BL/6  
polypeptide O54864 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 3
    cDNA 21
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2147928, MGI:2147944
References
more
  • Summaries
    All 90
    Developmental Gene Expression 22
    Gene Ontology 18
    Phenotypes 15
  • Earliest
    J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
  • Latest
    J:258325 Yaseen I, et al., Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB. EMBO J. 2018 Jan 17;37(2):183-200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory