Suv39h1
Gene Detail

Symbol Name ID

Suv39h1 suppressor of variegation 3-9 homolog 1 (Drosophila) MGI:1099440

Synonyms

DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.64 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

ChrX:8061171-8074760 bp, - strand From VEGA annotation of GRCm38   13590 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone H3-K9 methyltransferase
Gene Tree: Suv39h1

Human homologs

Human Homolog		SUV39H1, suppressor of variegation 3-9 homolog 1 (Drosophila)
NCBI Gene ID		6839
neXtProt AC		NX_O43463
Human Synonyms		KMT1A, MG44, SUV39H
Human Chr (Location)		Xp11.23; chrX:48555131-48567407 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(1) Gene trapped(7)
 

About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cell cycle, cell differentiation, ...
Component	chromatin silencing complex, chromosome, ...
Function	histone-lysine N-methyltransferase activity, histone methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (217)    Tissues (167)    Images (26)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	165
Northern blot	1
Western blot	2
RT-PCR	49

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(3) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017258 (Evidence)
Ensembl Gene Model	ENSMUSG00000039231 (Evidence)
Entrez Gene	20937 (Evidence)
EC	2.1.1.43
Consensus CDS Project	CCDS40846.1
International Mouse Knockout Project Status	Suv39h1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017258	VEGA Gene Model | MGI Sequence Detail	13590	C57BL/6J
transcript	OTTMUST00000041763	VEGA | MGI Sequence Detail	2778	Not Applicable
polypeptide	OTTMUSP00000018772	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023780	Chromo domain
InterPro	IPR023779	Chromo domain, conserved site
InterPro	IPR016197	Chromo domain-like
InterPro	IPR000953	Chromo domain/shadow
InterPro	IPR011381	Histone H3-K9 methyltransferase
InterPro	IPR003616	Post-SET domain
InterPro	IPR007728	Pre-SET domain
InterPro	IPR003606	Pre-SET zinc-binding sub-group
InterPro	IPR001214	SET domain
Protein Ontology	PR:000015844	histone-lysine N-methyltransferase SUV39H1

References

(Earliest) J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
(Latest) J:194983 Ideno H, et al., Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90
All references(66)

Other accession IDs

MGI:2147928, MGI:2147944