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Suv39h1 Gene Detail
Summary
  • Symbol
    Suv39h1
  • Name
    suppressor of variegation 3-9 homolog 1 (Drosophila)
  • Synonyms
    DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099440
    NCBI Gene: 20937
  • Gene Overview
    MyGene.info: SUV39H1
Location & Maps
more
  • Genetic Map
    Chromosome X, 3.64 cM, cytoband A1-A2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    SUV39H1, suppressor of variegation 3-9 homolog 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SUV39H1, suppressor of variegation 3-9 homolog 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H3-K9-HMTase 1, KMT1A, MG44, SUV39H
  • Links
    NCBI Gene ID: 6839
    neXtProt AC: NX_O43463

  • Chr Location
    Xp11.23; chrX:48695554-48709016 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    7
  • Targeted
    1
About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017258 VEGA Gene Model | MGI Sequence Detail 13590 C57BL/6J ±  kb
transcript OTTMUST00000041763 VEGA | MGI Sequence Detail 2778 Not Applicable  
polypeptide OTTMUSP00000018772 VEGA | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 27
    Genomic 3
    cDNA 20
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2147928, MGI:2147944
References
more
  • Summaries
    All 77
    Developmental Gene Expression 19
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
  • Latest
    J:229253 Spies N, et al., Constraint and divergence of global gene expression in the mammalian embryo. Elife. 2015;4:e05538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory