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Suv39h1
Gene Detail
 Symbol
Name
ID
Suv39h1
suppressor of variegation 3-9 homolog 1 (Drosophila)
MGI:1099440
Synonyms DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase
Feature Type protein coding gene
Genetic Map
Chromosome X
3.64 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
ChrX:8061171-8074760 bp, - strand
From VEGA annotation of GRCm38

  13590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone H3-K9 methyltransferase
Gene Tree: Suv39h1

Human
homologs
Human Homolog SUV39H1, suppressor of variegation 3-9 homolog 1 (Drosophila)
NCBI Gene ID 6839
neXtProt AC  NX_O43463
Human Synonyms  H3-K9-HMTase 1, KMT1A, MG44, SUV39H
Human Chr (Location)  Xp11.23; chrX:48695554-48709016 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(1) Gene trapped(7)
 
About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell cycle, cell differentiation, ...
Component chromatin silencing complex, chromosome, ...
Function histone-lysine N-methyltransferase activity, histone methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (217)    Tissues (167)    Images (26)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 19, 20, 22, 23, 28
Assay TypeResults
RNA in situ 165
Northern blot 1
Western blot 2
RT-PCR 49
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(3) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017258 (Evidence)
Ensembl Gene ModelENSMUSG00000039231 (Evidence)
Entrez Gene20937 (Evidence)
EC2.1.1.43
Consensus CDS ProjectCCDS40846.1
International Mouse Knockout Project StatusSuv39h1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017258 VEGA Gene Model | MGI Sequence Detail 13590 C57BL/6J ±  kb
transcript OTTMUST00000041763 VEGA | MGI Sequence Detail 2778 Not Applicable 
polypeptide OTTMUSP00000018772 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR011381 Histone H3-K9 methyltransferase
InterPro IPR003616 Post-SET domain
InterPro IPR007728 Pre-SET domain
InterPro IPR003606 Pre-SET zinc-binding sub-group
InterPro IPR001214 SET domain
Protein Ontology PR:000015844 histone-lysine N-methyltransferase SUV39H1
References (Earliest) J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
(Latest) J:205006 Dorr JR, et al., Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature. 2013 Sep 19;501(7467):421-5
All references(72)
Other
accession IDs
MGI:2147928, MGI:2147944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory