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Suv39h1
Gene Detail
Symbol

Name
ID
Suv39h1
suppressor of variegation 3-9 homolog 1 (Drosophila)
MGI:1099440
Synonyms
DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.64 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
ChrX:8061171-8074760 bp, - strand
From VEGA annotation of GRCm38

  13590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SUV39H1
Protein SuperFamily: histone H3-K9 methyltransferase
Gene Tree: Suv39h1

Human
homologs
SUV39H1, suppressor of variegation 3-9 homolog 1 (Drosophila)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6839
neXtProt AC: NX_O43463

Human Synonyms: H3-K9-HMTase 1, KMT1A, MG44, SUV39H

Human Chr (Location): Xp11.23; chrX:48695554-48709016 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(7) Targeted(1)
 
About one third of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.
 
Interactions
Suv39h1 interacts with 273 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell cycle, cell differentiation, ...
Component chromatin silencing complex, chromosome, ...
Function histone-lysine N-methyltransferase activity, histone methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (212)    Tissues (162)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
Northern blot 1
Western blot 2
RT-PCR 44
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN suv39h1a    NEW 
Molecular
reagents
All nucleic(27) Genomic(3) cDNA(20) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017258 (Evidence)
Ensembl Gene Model ENSMUSG00000039231 (Evidence)
Entrez Gene 20937 (Evidence)
EC 2.1.1.43
Consensus CDS Project CCDS40846.1, CCDS72337.1
International Mouse Phenotyping Consortium Status Suv39h1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017258 VEGA Gene Model | MGI Sequence Detail 13590 C57BL/6J ±  kb
transcript OTTMUST00000041763 VEGA | MGI Sequence Detail 2778 Not Applicable 
polypeptide OTTMUSP00000018772 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR011381 Histone H3-K9 methyltransferase
InterPro IPR003616 Post-SET domain
InterPro IPR007728 Pre-SET domain
InterPro IPR003606 Pre-SET zinc-binding sub-group
InterPro IPR001214 SET domain
Protein Ontology PR:000015844 histone-lysine N-methyltransferase SUV39H1
References
(Earliest) J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
(Latest) J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
All references(74)
Other
accession IDs
MGI:2147928, MGI:2147944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory