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Rad51b
Gene Detail
Symbol

Name
ID
Rad51b
RAD51 homolog B
MGI:1099436
Synonyms
mREC2, R51H2, Rad51b, Rad51l1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
35.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:79297351-79508656 bp, + strand
From Ensembl annotation of GRCm38

  211306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:50190  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RAD51B
Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51b

Human
homologs
RAD51B, RAD51 paralog B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5890
neXtProt AC: NX_O15315

Human Synonyms: R51H2, RAD51L1, REC2

Human Chr (Location): 14q23-q24.2; chr14:67819779-68683210 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Targeted(3)
Incidental mutations (data from APF )
 
Embryos homozygous for a knock-out allele are severely growth retarded and exhibit complete early embryonic lethality; interestingly, mutant embryos survive and develop further in a Trp53-null background.
 
Interactions
Rad51b interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blastocyst growth, cellular response to DNA damage stimulus, ...
Component nucleus, Rad51B-Rad51C-Rad51D-XRCC2 complex, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (7)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN rad51b    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(17)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000059060 (Evidence)
Entrez Gene 19363 (Evidence)
UniGene 341756
DFCI TC1584866, TC1592435
DoTS DT.40185575, DT.94267681
NIA Mouse Gene Index U014142
Consensus CDS Project CCDS56845.1
International Mouse Phenotyping Consortium Status Rad51b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059060 Ensembl Gene Model | MGI Sequence Detail 211306 C57BL/6J ±  kb
transcript ENSMUST00000079533 Ensembl | MGI Sequence Detail 1759 Not Applicable 
polypeptide ENSMUSP00000078490 Ensembl | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(62) UniProt(2)
Polymorphisms
SNPs within 2kb(3554 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3558)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
InterPro IPR030548 DNA repair protein RAD51 homologue 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013676 DNA repair protein RAD51 homolog 2
References
(Earliest) J:41747 Rice MC, et al., Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)
Other
accession IDs
MGI:2144860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory