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Rad51b Gene Detail
Summary
  • Symbol
    Rad51b
  • Name
    RAD51 paralog B
  • Synonyms
    mREC2, R51H2, Rad51b, Rad51l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099436
    NCBI Gene: 19363
  • Gene Overview
    MyGene.info: RAD51B
Location & Maps
more
  • Sequence Map
    Chr12:79297351-79508656 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      211306 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RAD51B, RAD51 paralog B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAD51B, RAD51 paralog B
    Orthology source: HomoloGene
  • Synonyms
    R51H2, RAD51L1, REC2
  • Links
    NCBI Gene ID: 5890
    neXtProt AC: NX_O15315

  • Chr Location
    14q23-q24.2; chr14:67819779-68683210 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    23
  • Targeted
    3
  • Genomic Mutations
    1 involving Rad51b
  • Incidental Mutations
    APF
Embryos homozygous for a knock-out allele are severely growth retarded and exhibit complete early embryonic lethality; interestingly, mutant embryos survive and develop further in a Trp53-null background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059060 Ensembl Gene Model | MGI Sequence Detail 211306 C57BL/6J ±  kb
transcript ENSMUST00000079533 Ensembl | MGI Sequence Detail 1759 Not Applicable  
polypeptide ENSMUSP00000078490 Ensembl | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3731 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013676 DNA repair protein RAD51 homolog 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013632 DNA recombination and repair protein Rad51, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR030548 DNA repair protein RAD51 homologue 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144860
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:41747 Rice MC, et al., Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory