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Coq4 Gene Detail
Summary
  • Symbol
    Coq4
  • Name
    coenzyme Q4
  • Synonyms
    D2Ertd97e, EST-MNCb4625
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098826
    NCBI Gene: 227683
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:29677505-29687947 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 20.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098826
 protein coding gene Chr2:29677505-29687947 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025543
 protein coding gene Chr2:27959349-27969680 (+)
A/J MGP_AJ_G0025521
 protein coding gene Chr2:26858177-26869246 (+)
AKR/J MGP_AKRJ_G0025490
 protein coding gene Chr2:27762306-27772573 (+)
BALB/cJ MGP_BALBcJ_G0025516
 protein coding gene Chr2:26989983-27000415 (+)
C3H/HeJ MGP_C3HHeJ_G0025278
 protein coding gene Chr2:27687030-27698611 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025961
 protein coding gene Chr2:28861550-28871992 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023370
 protein coding gene Chr2:25648447-25658951 (+)
CAST/EiJ MGP_CASTEiJ_G0024741
 protein coding gene Chr2:27579794-27591405 (+)
CBA/J MGP_CBAJ_G0025255
 protein coding gene Chr2:29858362-29870737 (+)
DBA/2J MGP_DBA2J_G0025388
 protein coding gene Chr2:26655785-26666411 (+)
FVB/NJ MGP_FVBNJ_G0025351
 protein coding gene Chr2:26458927-26469350 (+)
LP/J MGP_LPJ_G0025474
 protein coding gene Chr2:27876027-27888932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025381
 protein coding gene Chr2:29788466-29798935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026020
 protein coding gene Chr2:27677912-27688308 (+)
PWK/PhJ MGP_PWKPhJ_G0024487
 protein coding gene Chr2:26483051-26493721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024287
 protein coding gene Chr2:27765361-27775996 (+)
WSB/EiJ MGP_WSBEiJ_G0024809
 protein coding gene Chr2:27804100-27814469 (+)



Homology
more
  • Human Ortholog
    COQ4, coenzyme Q4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COQ4, coenzyme Q4
  • Synonyms
    CGI-92, COQ10D7, SPAX10
  • Links
    NCBI Gene ID: 51117
    neXtProt AC: NX_Q9Y3A0
    UniProt: Q9Y3A0

  • Chr Location
    9q34.11; chr9:128322544-128334072 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COQ4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in chorion formation and placentation, abnormal trophoblast layer morphology, and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    19
  • cDNA Data
    32
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227683 NCBI Gene Model | MGI Sequence Detail 10443 C57BL/6J ±  kb
    transcript NR_145503 RefSeq | MGI Sequence Detail 3026 ZRU/MplStud  
    polypeptide Q8BGB8 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005753 ubiquinone biosynthesis protein COQ4, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR007715 Ubiquinone biosynthesis protein Coq4
      IPR027540 Ubiquinone biosynthesis protein Coq4, eukaryotic
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 32
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory