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Cdk12 Gene Detail
Summary
  • Symbol
    Cdk12
  • Name
    cyclin-dependent kinase 12
  • Synonyms
    1810022J16Rik, Crk7, Crkrs, D11Ertd752e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098802
    NCBI Gene: 69131
  • Gene Overview
    MyGene.info: CDK12
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:98203059-98278504 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75446 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CDK12, cyclin dependent kinase 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDK12, cyclin dependent kinase 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRK7, CRKR, CRKRS
  • Links
    NCBI Gene ID: 51755
    neXtProt AC: NX_Q9NYV4
    UniProt: Q9NYV4

  • Chr Location
    17q12; chr17:39461486-39567560 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality between implantation and E6.5 with decreased proliferation and increased apoptosis in the inner cell mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002637 VEGA Gene Model | MGI Sequence Detail 75446 C57BL/6J ±  kb
    transcript OTTMUST00000005150 VEGA | MGI Sequence Detail 5143 Not Applicable  
    polypeptide OTTMUSP00000002446 VEGA | MGI Sequence Detail 1484 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      245 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
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    MGI:1289232, MGI:1916381, MGI:2144249
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:241332 Chen HR, et al., Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory