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Otud4 Gene Detail
Summary
  • Symbol
    Otud4
  • Name
    OTU domain containing 4
  • Synonyms
    4930431L18Rik, D8Ertd69e, mKIAA1046
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098801
    NCBI Gene: 73945
  • Gene Overview
    MyGene.info: OTUD4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:79639676-79677755 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 37.74 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098801
protein coding gene Chr8:79639618-79677755 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033813
protein coding gene Chr8:80321831-80360978 (+)
A/J MGP_AJ_G0033795
protein coding gene Chr8:77132292-77170357 (+)
AKR/J MGP_AKRJ_G0033722
protein coding gene Chr8:79438359-79476410 (+)
BALB/cJ MGP_BALBcJ_G0033789
protein coding gene Chr8:77233897-77274096 (+)
C3H/HeJ MGP_C3HHeJ_G0033498
protein coding gene Chr8:80060585-80100402 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034309
protein coding gene Chr8:83407867-83447571 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031250
protein coding gene Chr8:71199239-71238532 (+)
CAST/EiJ MGP_CASTEiJ_G0032829
protein coding gene Chr8:79401583-79439507 (+)
CBA/J MGP_CBAJ_G0033477
protein coding gene Chr8:86346597-86384590 (+)
DBA/2J MGP_DBA2J_G0033630
protein coding gene Chr8:76828268-76866862 (+)
FVB/NJ MGP_FVBNJ_G0033575
protein coding gene Chr8:75797251-75836216 (+)
LP/J MGP_LPJ_G0033720
protein coding gene Chr8:80399117-80438325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033618
protein coding gene Chr8:88902744-88941593 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034326
protein coding gene Chr8:79451573-79495229 (+)
PWK/PhJ MGP_PWKPhJ_G0032532
protein coding gene Chr8:76098112-76137129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032370
protein coding gene Chr8:78270864-78309345 (+)
WSB/EiJ MGP_WSBEiJ_G0032942
protein coding gene Chr8:79789051-79827140 (+)



Homology
more
  • Human Ortholog
    OTUD4, OTU deubiquitinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OTUD4, OTU deubiquitinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DUBA6, HIN1, HSHIN1
  • Links
    NCBI Gene ID: 54726
    neXtProt AC: NX_Q01804
    UniProt: Q01804

  • Chr Location
    4q31.21; chr4:145133650-145180019 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73945 NCBI Gene Model | MGI Sequence Detail 38080 C57BL/6J ±  kb
transcript NM_001256033 RefSeq | MGI Sequence Detail 7327 C57BL/6  
polypeptide B2RRE7 UniProt | EBI | MGI Sequence Detail 1107 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1921195, MGI:2138957
References
more
  • Summaries
    All 37
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:257326 Zhao Y, et al., OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Mol Cell. 2018 Feb 1;69(3):505-516.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory