Lbp MGI Mouse Gene Detail - MGI:1098776 - lipopolysaccharide binding protein

Symbol

Lbp
Name

lipopolysaccharide binding protein
Synonyms

Bpifd2

Feature Type

protein coding gene
IDs

MGI:1098776
NCBI Gene: 16803
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:158148413-158174772 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM
Mapping Data

3 experiments

SNPs within 2kb

382 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098776	protein coding gene	Chr2:158148413-158174772 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026792	protein coding gene	Chr2:163374167-163403445 (+)
A/J	MGP_AJ_G0026758	protein coding gene	Chr2:156821422-156847735 (+)
AKR/J	MGP_AKRJ_G0026729	protein coding gene	Chr2:161445660-161472237 (+)
BALB/cJ	MGP_BALBcJ_G0026767	protein coding gene	Chr2:157125810-157152343 (+)
C3H/HeJ	MGP_C3HHeJ_G0026509	protein coding gene	Chr2:161770120-161799061 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027216	protein coding gene	Chr2:168242603-168272934 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024586	protein coding gene	Chr2:150260009-150285759 (+)
CAST/EiJ	MGP_CASTEiJ_G0025971	protein coding gene	Chr2:162126598-162159348 (+)
CBA/J	MGP_CBAJ_G0026486	protein coding gene	Chr2:174274596-174303713 (+)
DBA/2J	MGP_DBA2J_G0026624	protein coding gene	Chr2:155995336-156021977 (+)
FVB/NJ	MGP_FVBNJ_G0026591	protein coding gene	Chr2:154404284-154431265 (+)
LP/J	MGP_LPJ_G0026727	protein coding gene	Chr2:163463084-163494771 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026612	protein coding gene	Chr2:178071373-178099034 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027272	protein coding gene	Chr2:161273165-161299694 (+)
PWK/PhJ	MGP_PWKPhJ_G0025705	protein coding gene	Chr2:155522054-155549670 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025508	protein coding gene	Chr2:160180714-160213183 (+)
WSB/EiJ	MGP_WSBEiJ_G0026041	protein coding gene	Chr2:162161114-162187432 (+)

Human Ortholog

LBP, lipopolysaccharide binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LBP, lipopolysaccharide binding protein
Synonyms

BPIFD2
Links

HGNC:6517

NCBI Gene ID: 3929

neXtProt AC: NX_P18428

UniProt: P18428
Chr Location

20q11.23; chr20:38346482-38377013 (+) GRCh38

MGI Vertebrate Homology

Lbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LBP
Protein SuperFamily

Lipid_binding_protein
Gene Tree

Lbp

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Phenotype Summary

16 phenotypes from 3 alleles in 5 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice have a generally normal phenotype but have an increased sensitivity to infection by gram negative bacteria.

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All GO Annotations

70
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

8
cDNA Data

170
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS16988.1

Ensembl

ENSMUSG00000016024 (Evidence)
NCBI Gene

16803

			Length	Strain/Species	Flank
genomic	16803	NCBI Gene Model \| MGI Sequence Detail	26360	C57BL/6J	± kb
transcript	NM_008489	RefSeq \| MGI Sequence Detail	2528	ZRU/MplStud
polypeptide	Q61805	UniProt \| EBI \| MGI Sequence Detail	481	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001773 lipopolysaccharide-binding protein

(term hierarchy)
PDB

4M4D
InterPro Domains

IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily

IPR032942 BPI/LBP/Plunc family

IPR030675 Lipid binding protein BPI/LBP

IPR017954 Lipid-binding serum glycoprotein, conserved site

IPR001124 Lipid-binding serum glycoprotein, C-terminal

IPR017942 Lipid-binding serum glycoprotein, N-terminal

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All nucleic 174

Genomic 3

cDNA 170

Primer pair 1

Microarray probesets 3

Summaries

All 68

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 29
Earliest

J:45749 Lengacher S, et al., Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995-96;47(4):165-72
Latest

J:343446 Chen HJ, et al., Fetal CCL2 signaling mediates offspring social behavior and recapitulates effects of prenatal stress. Brain Behav Immun. 2024 Jan;115:308-318

TSS for Lbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21309	Chr2:158148545-158148573 (+)	146 bp
Tssr21310	Chr2:158155158-158155180 (+)	6,756 bp
Tssr21311	Chr2:158155184-158155208 (+)	6,783 bp
Tssr21312	Chr2:158162215-158162232 (+)	13,811 bp
Tssr21313	Chr2:158166507-158166514 (+)	18,098 bp
Tssr21314	Chr2:158170279-158170289 (+)	21,871 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23