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Lbp Gene Detail
Summary
  • Symbol
    Lbp
  • Name
    lipopolysaccharide binding protein
  • Synonyms
    Bpifd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098776
    NCBI Gene: 16803
Location & Maps
more
  • Sequence Map
    Chr2:158306493-158332852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26360 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LBP, lipopolysaccharide binding protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    LBP, lipopolysaccharide binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BPIFD2
  • Links
    NCBI Gene ID: 3929
    neXtProt AC: NX_P18428

  • Chr Location
    20q11.23; chr20:38346411-38377011 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 5 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Incidental Mutations
Homozygous mice have a generally normal phenotype but have an increased sensitivity to infection by gram negative bacteria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015936 VEGA Gene Model | MGI Sequence Detail 26360 C57BL/6J ±  kb
transcript OTTMUST00000037860 VEGA | MGI Sequence Detail 2525 Not Applicable  
polypeptide OTTMUSP00000016997 VEGA | MGI Sequence Detail 481 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    382 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001773 lipopolysaccharide-binding protein
  • PDB
  • InterPro Domains
    IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
    IPR032942 BPI/LBP/Plunc family
    IPR030675 Lipid binding protein BPI/LBP
    IPR017954 Lipid-binding serum glycoprotein, conserved site
    IPR001124 Lipid-binding serum glycoprotein, C-terminal
    IPR017942 Lipid-binding serum glycoprotein, N-terminal
    IPR030180 Lipopolysaccharide-binding protein
Molecular
Reagents
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  • All nucleic 173
    Genomic 3
    cDNA 169
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:45749 Lengacher S, et al., Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995-96;47(4):165-72
  • Latest
    J:222669 Tanimura N, et al., The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory