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Lbp
Gene Detail
 Symbol
Name
ID
Lbp
lipopolysaccharide binding protein
MGI:1098776
Synonyms Bpifd2
Feature Type protein coding gene
Genetic Map
Chromosome 2
78.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:158306493-158332852 bp, + strand
From VEGA annotation of GRCm38

  26360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: phospho/glycolipid-binding protein, BPI/LBP type
Gene Tree: Lbp

Human
homologs
Human Homolog LBP, lipopolysaccharide binding protein
NCBI Gene ID 3929
neXtProt AC  NX_P18428
Human Synonyms  BPIFD2
Human Chr (Location)  20q11.23; chr20:38346411-38377011 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice have a generally normal phenotype but have an increased sensitivity to infection by gram negative bacteria.
 
Interactions
Lbp interacts with 158 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process acute-phase response, cellular response to lipopolysaccharide, ...
Component cell surface, extracellular region, ...
Function lipid binding, lipopolysaccharide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (33)    Tissues (4)    Images (23)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 33
cDNA source data(169)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(173) Genomic(3) cDNA(169) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015936 (Evidence)
Ensembl Gene ModelENSMUSG00000016024 (Evidence)
Entrez Gene16803 (Evidence)
UniGene218846
DFCITC1575413, TC1699220, TC1744431
DoTSDT.532810, DT.94248174, DT.94357186
PDB4M4D
Consensus CDS ProjectCCDS16988.1
International Mouse Knockout Project StatusLbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015936 VEGA Gene Model | MGI Sequence Detail 26360 C57BL/6J ±  kb
transcript OTTMUST00000037860 VEGA | MGI Sequence Detail 2525 Not Applicable 
polypeptide OTTMUSP00000016997 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(383 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
InterPro IPR017954 Lipid-binding serum glycoprotein, conserved site
InterPro IPR001124 Lipid-binding serum glycoprotein, C-terminal
InterPro IPR017942 Lipid-binding serum glycoprotein, N-terminal
Protein Ontology PR:000001773 lipopolysaccharide-binding protein
References (Earliest) J:45749 Lengacher S, et al., Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995-96;47(4):165-72
(Latest) J:212418 Sallam T, et al., The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. J Lipid Res. 2014 Mar 26;55(6):1120-1130
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory