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Sgo2a Gene Detail
Summary
  • Symbol
    Sgo2a
  • Name
    shugoshin 2A
  • Synonyms
    1110007N04Rik, 5730576N04Rik, D1Ertd8e, Sgol2, Sgol2a, Tripin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098767
    NCBI Gene: 68549
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58035130-58065058 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098767
protein coding gene Chr1:58024499-58065436 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016044
protein coding gene Chr1:57827263-57859354 (+)
A/J MGP_AJ_G0016027
protein coding gene Chr1:55818052-55847733 (+)
AKR/J MGP_AKRJ_G0015983
protein coding gene Chr1:57321609-57351358 (+)
BALB/cJ MGP_BALBcJ_G0015982
protein coding gene Chr1:55852003-55881803 (+)
C3H/HeJ MGP_C3HHeJ_G0015814
protein coding gene Chr1:57592709-57624118 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016435
protein coding gene Chr1:60193197-60225898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014156
protein coding gene Chr1:51760046-51789616 (+)
CAST/EiJ MGP_CASTEiJ_G0015396
protein coding gene Chr1:56851161-56883493 (+)
CBA/J MGP_CBAJ_G0015786
protein coding gene Chr1:61944241-61975366 (+)
DBA/2J MGP_DBA2J_G0015887
protein coding gene Chr1:55224778-55254607 (+)
FVB/NJ MGP_FVBNJ_G0015889
protein coding gene Chr1:54559246-54589542 (+)
LP/J MGP_LPJ_G0015959
protein coding gene Chr1:58721333-58754566 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015909
protein coding gene Chr1:64962140-64993579 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016482
protein coding gene Chr1:57305598-57337108 (+)
PWK/PhJ MGP_PWKPhJ_G0015182
protein coding gene Chr1:54594264-54625054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014963
protein coding gene Chr1:56882111-56913590 (+)
WSB/EiJ MGP_WSBEiJ_G0015459
protein coding gene Chr1:56980276-57010190 (+)



Homology
more
  • Human Ortholog
    SGO2, shugoshin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGO2, shugoshin 2
  • Synonyms
    SGOL2, TRIPIN
  • Links
    NCBI Gene ID: 151246
    neXtProt AC: NX_Q562F6
    UniProt: Q562F6

  • Chr Location
    2q33.1; chr2:200510008-200584096 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display male and female infertility with abnormalities in meiosis but not in mitosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026039 Ensembl Gene Model | MGI Sequence Detail 29929 C57BL/6J ±  kb
    transcript ENSMUST00000027202 Ensembl | MGI Sequence Detail 4939 Not Applicable  
    polypeptide ENSMUSP00000027202 Ensembl | MGI Sequence Detail 1164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR038889 Shugoshin 1/2
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915799, MGI:1917915, MGI:2138427, MGI:2138513
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:275812 Previato de Almeida L, et al., Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9417-9422

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory