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Psmc3
Gene Detail
Symbol

Name
ID
Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
MGI:1098754
Synonyms
Tat binding protein 1, TBP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:91054009-91066369 bp, + strand
From VEGA annotation of GRCm38

  12361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ATP-dependent 26S proteinase
Gene Tree: Psmc3

Human
homologs
Human Homolog PSMC3, proteasome (prosome, macropain) 26S subunit, ATPase, 3
NCBI Gene ID 5702
neXtProt AC  NX_P17980
Human Synonyms  TBP1
Human Chr (Location)  11p11.2; chr11:47418769-47426473 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Genomic Mutations involving Psmc3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos.
 
Interactions
Psmc3 interacts with 35 markers (Mir132, Mir141, Mir203, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process blastocyst development, protein catabolic process
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function ATP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (111)    Tissues (111)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
cDNA source data(312)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(313) cDNA(312) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000014341 (Evidence)
Ensembl Gene ModelENSMUSG00000002102 (Evidence)
Entrez Gene19182 (Evidence)
UniGene289832
DFCITC1596909, TC1573242
DoTSDT.55195176, DT.497181, DT.55263750, DT.101720302
NIA Mouse Gene IndexU002116
Consensus CDS ProjectCCDS16423.1
International Mouse Knockout Project StatusPsmc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014341 VEGA Gene Model | MGI Sequence Detail 12361 C57BL/6J ±  kb
transcript OTTMUST00000084165 VEGA | MGI Sequence Detail 1819 Not Applicable 
polypeptide OTTMUSP00000045321 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005937 26S proteasome subunit P45
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013380 26S protease regulatory subunit 6A
References
(Earliest) J:43564 Tanaka T, et al., Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81
(Latest) J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory