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Psmc3 Gene Detail
Summary
  • Symbol
    Psmc3
  • Name
    proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Synonyms
    Tat binding protein 1, TBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098754
    NCBI Gene: 19182
  • Gene Overview
    MyGene.info: PSMC3
Location & Maps
more
  • Sequence Map
    Chr2:91054009-91066369 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12361 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.44 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PSMC3, proteasome 26S subunit, ATPase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSMC3, proteasome 26S subunit, ATPase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TBP1
  • Links
    NCBI Gene ID: 5702
    neXtProt AC: NX_P17980

  • Chr Location
    11p11.2; chr11:47418769-47426473 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Psmc3
  • Incidental Mutations
Mice homozygous for disruptions in this gene die as embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014341 VEGA Gene Model | MGI Sequence Detail 12361 C57BL/6J ±  kb
transcript OTTMUST00000084165 VEGA | MGI Sequence Detail 1819 Not Applicable  
polypeptide OTTMUSP00000045321 VEGA | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000013380 26S protease regulatory subunit 6A
  • InterPro Domains
    IPR005937 26S proteasome subunit P45
    IPR003593 AAA+ ATPase domain
    IPR003960 ATPase, AAA-type, conserved site
    IPR003959 ATPase, AAA-type, core
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 313
    cDNA 312
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:43564 Tanaka T, et al., Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81
  • Latest
    J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory