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Slc46a1
Gene Detail
Symbol

Name
ID
Slc46a1
solute carrier family 46, member 1
MGI:1098733
Synonyms
1110002C08Rik, D11Ertd18e, HCP1, heme carrier protein 1, PCFT
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:78465697-78472059 bp, + strand
From VEGA annotation of GRCm38

  6363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC46A1
Gene Tree: Slc46a1

Human
homologs
SLC46A1, solute carrier family 46 (folate transporter), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 113235
neXtProt AC: NX_Q96NT5

Human Synonyms: G21, HCP1, PCFT

Human Chr (Location): 17q11.2; chr17:28394642-28406212 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC46A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Genomic Mutations involving Slc46a1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased circulating and liver levels of N-homocysteine and total homocysteine.
 
Interactions
Slc46a1 interacts with 69 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process folic acid import into cell, folic acid transport, ...
Component apical plasma membrane, brush border membrane, ...
Function folic acid binding, folic acid transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (12)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 11
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc46a1 ; ZFIN slc46a1    NEW 
Molecular
reagents
All nucleic(55) cDNA(52) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000134 (Evidence)
Ensembl Gene Model ENSMUSG00000020829 (Evidence)
Entrez Gene 52466 (Evidence)
UniGene 131618
DFCI TC1576683
DoTS DT.528720, DT.55205583, DT.97342048
NIA Mouse Gene Index U013020
Consensus CDS Project CCDS25104.1
International Mouse Phenotyping Consortium Status Slc46a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000134 VEGA Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
transcript OTTMUST00000000430 VEGA | MGI Sequence Detail 1978 Not Applicable 
polypeptide OTTMUSP00000000186 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015150 proton-coupled folate transporter
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203885 Kooistra M, et al., Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos. Biol Reprod. 2013 Sep;89(3):63
All references(45)
Other
accession IDs
MGI:1915739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory