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Slc46a1 Gene Detail
Summary
  • Symbol
    Slc46a1
  • Name
    solute carrier family 46, member 1
  • Synonyms
    1110002C08Rik, D11Ertd18e, HCP1, heme carrier protein 1, PCFT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098733
    NCBI Gene: 52466
  • Gene Overview
    MyGene.info: SLC46A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:78465697-78472059 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6363 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SLC46A1, solute carrier family 46 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC46A1, solute carrier family 46 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G21, HCP1, PCFT
  • Links
    NCBI Gene ID: 113235
    neXtProt AC: NX_Q96NT5
    UniProt: Q96NT5

  • Chr Location
    17q11.2; chr17:28394642-28406630 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased circulating and liver levels of N-homocysteine and total homocysteine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000134 VEGA Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
    transcript OTTMUST00000000430 VEGA | MGI Sequence Detail 1978 Not Applicable  
    polypeptide OTTMUSP00000000186 VEGA | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      28 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 52
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915739
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory