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Slc46a1
Gene Detail
 Symbol
Name
ID
Slc46a1
solute carrier family 46, member 1
MGI:1098733
Synonyms 1110002C08Rik, D11Ertd18e, HCP1, heme carrier protein 1, PCFT
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:78465697-78472059 bp, + strand
From VEGA annotation of GRCm38

  6363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc46a1

Human
homologs
Human Homolog SLC46A1, solute carrier family 46 (folate transporter), member 1
NCBI Gene ID 113235
neXtProt AC  NX_Q96NT5
Human Synonyms  G21, HCP1, PCFT
Human Chr (Location)  17q11.2; chr17:28394642-28406212 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC46A1
Alleles
and
phenotypes
All alleles(6) : Targeted(3) Gene trapped(3)
 
Mice homozygous for a knock-out allele exhibit increased circulating and liver levels of N-homocysteine and total homocysteine.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process folic acid transport, heme transport, ...
Component apical plasma membrane, brush border membrane, ...
Function folic acid binding, folic acid transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) cDNA(52) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000134 (Evidence)
Ensembl Gene ModelENSMUSG00000020829 (Evidence)
Entrez Gene52466 (Evidence)
UniGene131618
DFCITC1576683
DoTSDT.528720, DT.55205583, DT.97342048
NIA Mouse Gene IndexU013020
Consensus CDS ProjectCCDS25104.1
International Mouse Knockout Project StatusSlc46a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000134 VEGA Gene Model | MGI Sequence Detail 6363 C57BL/6J ±  kb
transcript OTTMUST00000000430 VEGA | MGI Sequence Detail 1978 Not Applicable 
polypeptide OTTMUSP00000000186 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015150 proton-coupled folate transporter
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197668 Wang X, et al., Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. FASEB J. 2013 Mar;27(3):1167-75
All references(44)
Other
accession IDs
MGI:1915739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory